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    Zap70 zeta chain of T cell receptor associated protein kinase 70 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301348, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zap70provided by RGD
    Official Full Name
    zeta chain of T cell receptor associated protein kinase 70provided by RGD
    Primary source
    RGD:3983
    See related
    EnsemblRapid:ENSRNOG00000016995 AllianceGenome:RGD:3983
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Srk
    Summary
    Predicted to enable several functions, including ATP binding activity; non-membrane spanning protein tyrosine kinase activity; and phosphotyrosine residue binding activity. Predicted to be involved in cell differentiation; cell surface receptor protein tyrosine kinase signaling pathway; and innate immune response. Predicted to act upstream of or within several processes, including T cell selection; positive regulation of alpha-beta T cell activation; and protein phosphorylation. Predicted to be located in several cellular components, including cell-cell junction; immunological synapse; and membrane raft. Predicted to be part of T cell receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 48 and severe combined immunodeficiency. Orthologous to human ZAP70 (zeta chain of T cell receptor associated protein kinase 70). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 201.7), Spleen (RPKM 40.5) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zap70 in Genome Data Viewer
    Location:
    9q21
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (46485605..46507552)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (38989750..39011701)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (43331149..43353097)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 2 open reading frame 92 Neighboring gene actin related protein 1B Neighboring gene U4 spliceosomal RNA Neighboring gene transmembrane protein 131 Neighboring gene uncharacterized LOC134480356 Neighboring gene von Willebrand factor A domain containing 3B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase. Arpaia E, et al. Cell, 1994 Mar 11. PMID 8124727
    2. Syk kinase is phosphorylated in specific areas of the developing nervous system. Hatterer E, et al. Neurosci Res, 2011 Jun. PMID 21354221
    3. ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain. Chan AC, et al. Cell, 1992 Nov 13. PMID 1423621
    4. RNA-Sequencing Analysis and Expression of Lymphocyte-Specific Protein Tyrosine Kinase, Linker for Activation of T Cells, and 70-kDa T-Cell Receptor Zeta-Chain Associated Protein Kinase in Rat Liver Transplant Rejection. Xuan J, et al. Exp Clin Transplant, 2023 Dec. PMID 38263783
    5. The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling. Cheng AM, et al. Proc Natl Acad Sci U S A, 1997 Sep 2. PMID 9275205, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNA-Sequencing Analysis and Expression of Lymphocyte-Specific Protein Tyrosine Kinase, Linker for Activation of T Cells, and 70-kDa T-Cell Receptor Zeta-Chain Associated Protein Kinase in Rat Liver Transplant Rejection.
      Title: RNA-Sequencing Analysis and Expression of Lymphocyte-Specific Protein Tyrosine Kinase, Linker for Activation of T Cells, and 70-kDa T-Cell Receptor Zeta-Chain Associated Protein Kinase in Rat Liver Transplant Rejection.
    2. ZAP-70 is present in neurons of different structures including the cerebellum, the hippocampus, the visual system and the olfactory system.
      Title: Syk kinase is phosphorylated in specific areas of the developing nervous system.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108902

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of alpha-beta T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within beta selection ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative thymic T cell selection ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of alpha-beta T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of alpha-beta T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive thymic T cell selection ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within thymic T cell selection ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of T cell receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in immunological synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein kinase ZAP-70
    Names
    syk-related protein tyrosine kinase
    zeta-chain (TCR) associated protein kinase 70
    NP_001012002.1
    XP_006244823.1
    XP_063122964.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012002.1 → NP_001012002.1  tyrosine-protein kinase ZAP-70

      See identical proteins and their annotated locations for NP_001012002.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089855
      UniProtKB/TrEMBL
      A0A0R4J8U1, A6INF5
      Related
      ENSRNOP00000092439.2, ENSRNOT00000110442.2
      Conserved Domains (4) summary
      cd09938
      Location:8 → 111
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd05115
      Location:328 → 596
      PTKc_Zap-70; Catalytic domain of the Protein Tyrosine Kinase, Zeta-chain-associated protein of 70kDa
      pfam07714
      Location:338 → 588
      Pkinase_Tyr; Protein tyrosine kinase
      cl15255
      Location:152 → 256
      SH2; Src homology 2 (SH2) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      46485605..46507552
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244761.5 → XP_006244823.1  tyrosine-protein kinase ZAP-70 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AHV6
      Related
      ENSRNOP00000023036.6, ENSRNOT00000023036.9
      Conserved Domains (4) summary
      cd09938
      Location:32 → 135
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd05115
      Location:352 → 620
      PTKc_Zap-70; Catalytic domain of the Protein Tyrosine Kinase, Zeta-chain-associated protein of 70kDa
      pfam07714
      Location:362 → 612
      Pkinase_Tyr; Protein tyrosine kinase
      cl15255
      Location:176 → 280
      SH2; Src homology 2 (SH2) domain

    2. XM_063266894.1 → XP_063122964.1  tyrosine-protein kinase ZAP-70 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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