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    MTM1 Mtm1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853173, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MTM1
    Official Full Name
    Mtm1p
    Primary source
    SGD:S000003489
    Locus tag
    YGR257C
    See related
    AllianceGenome:SGD:S000003489; FungiDB:YGR257C; VEuPathDB:YGR257C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables pyridoxal phosphate binding activity. Involved in intracellular iron ion homeostasis and pyridoxal phosphate transport. Located in mitochondrion. Orthologous to human SLC25A39 (solute carrier family 25 member 39) and SLC25A40 (solute carrier family 25 member 40). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See MTM1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (1006205..1007305, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene tRNA-Thr Neighboring gene phosphogluconate dehydrogenase (decarboxylating) GND2 Neighboring gene ssDNA endodeoxyribonuclease RAD2 Neighboring gene Tna1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Screen in Saccharomyces cerevisiae for transposon insertion sites able to rescue phenotype of MTM1 deletion mutant using mTn-lacZ/LEU2 transposon library]. Wang J, et al. Wei Sheng Wu Xue Bao, 2010 Jan. PMID 20344951
    2. Expression and purification of recombinant Saccharomyces cerevisiae mitochondrial carrier protein YGR257Cp (Mtm1p). Whittaker MM, et al. Protein Expr Purif, 2014 Jan. PMID 24184947, Free PMC Article
    3. The Mtm1p carrier and pyridoxal 5'-phosphate cofactor trafficking in yeast mitochondria. Whittaker MM, et al. Arch Biochem Biophys, 2015 Feb 15. PMID 25637770, Free PMC Article
    4. Manganese activation of superoxide dismutase 2 in Saccharomyces cerevisiae requires MTM1, a member of the mitochondrial carrier family. Luk E, et al. Proc Natl Acad Sci U S A, 2003 Sep 2. PMID 12890866, Free PMC Article
    5. The effects of mitochondrial iron homeostasis on cofactor specificity of superoxide dismutase 2. Yang M, et al. EMBO J, 2006 Apr 19. PMID 16601688, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MTM1 plays an important role in the regulation of zinc tolerance in Saccharomyces cerevisiae.
      Title: MTM1 plays an important role in the regulation of zinc tolerance in Saccharomyces cerevisiae.
    2. The mitochondrial proteome of Deltamtm1 knockout yeast is depleted of pyridoxal 5'-phosphate.
      Title: The Mtm1p carrier and pyridoxal 5'-phosphate cofactor trafficking in yeast mitochondria.
    3. transposon insertions in two genes were able to rescue the growth defect resulting from MTM1 deletion on nonfermentable carbon source.
      Title: [Screen in Saccharomyces cerevisiae for transposon insertion sites able to rescue phenotype of MTM1 deletion mutant using mTn-lacZ/LEU2 transposon library].
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables pyridoxal phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in import into the mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyridoxal phosphate transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mtm1p
    NP_011773.3
    • Mitochondrial protein of the mitochondrial carrier family; high affinity pyridoxal 5'-phosphate (PLP) transporter, important for delivery of the PLP cofactor to mitochondrial enzymes; involved in mitochondrial iron homeostasis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      1006205..1007305 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181386.3 → NP_011773.3  TPA: Mtm1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011773.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV37, P53320
      UniProtKB/TrEMBL
      A6ZUR5
      Conserved Domains (1) summary
      pfam00153
      Location:264 → 364
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53320.1

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