U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PRP3 U4/U6-U5 snRNP complex subunit PRP3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852084, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    PRP3
    Official Full Name
    U4/U6-U5 snRNP complex subunit PRP3
    Primary source
    SGD:S000002881
    Locus tag
    YDR473C
    See related
    AllianceGenome:SGD:S000002881; FungiDB:YDR473C; VEuPathDB:YDR473C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RNA3
    Summary
    Involved in spliceosomal snRNP assembly. Part of U4/U6 x U5 tri-snRNP complex. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 18. Orthologous to human PRPF3 (pre-mRNA processing factor 3). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PRP3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1404445..1405854, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene TRAPP subunit TRS31 Neighboring gene Jip4p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular cloning of Saccharomyces cerevisiae MGC1/YDR473c gene which is essential for cell growth. Fujimura H. Antonie Van Leeuwenhoek, 2000 Jan. PMID 10696880
    2. A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing. Liu S, et al. Elife, 2015 Jul 10. PMID 26161500, Free PMC Article
    3. The yeast Prp3 protein is a U4/U6 snRNP protein necessary for integrity of the U4/U6 snRNP and the U4/U6.U5 tri-snRNP. Anthony JG, et al. RNA, 1997 Oct. PMID 9326489, Free PMC Article
    4. Identification and nuclear localization of yeast pre-messenger RNA processing components: RNA2 and RNA3 proteins. Last RL, et al. J Cell Biol, 1986 Dec. PMID 3536958, Free PMC Article
    5. Functional and structural characterization of the prp3 binding domain of the yeast prp4 splicing factor. Ayadi L, et al. J Mol Biol, 1998 Dec 4. PMID 9826507

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spliceosomal snRNP assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U4/U6 x U5 tri-snRNP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    U4/U6-U5 snRNP complex subunit PRP3
    NP_010761.3
    • Splicing factor; component of the U4/U6-U5 snRNP complex

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1404445..1405854 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180781.3 → NP_010761.3  TPA: U4/U6-U5 snRNP complex subunit PRP3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010761.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT97, Q03338
      UniProtKB/TrEMBL
      B3LFJ2, B5VH02, C7GKR3, C8Z632, G2WBK3, N1P901
      Conserved Domains (2) summary
      pfam06544
      Location:342 → 464
      DUF1115; Protein of unknown function (DUF1115)
      pfam08572
      Location:67 → 317
      PRP3; pre-mRNA processing factor 3 (PRP3)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03338.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools