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    Slc66a1 solute carrier family 66 member 1 [ Mus musculus (house mouse) ]

    Gene ID: 212555, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Slc66a1provided by MGI
    Official Full Name
    solute carrier family 66 member 1provided by MGI
    Primary source
    MGI:MGI:2384837
    See related
    Ensembl:ENSMUSG00000028744 AllianceGenome:MGI:2384837
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pqlc2
    Summary
    Predicted to enable L-arginine transmembrane transporter activity; L-histidine transmembrane transporter activity; and L-lysine transmembrane transporter activity. Predicted to be involved in L-amino acid transport and intracellular amino acid homeostasis. Predicted to be located in intracellular membrane-bounded organelle and organelle membrane. Predicted to be active in lysosomal membrane. Is expressed in embryo. Orthologous to human SLC66A1 (solute carrier family 66 member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in spleen adult (RPKM 7.2), kidney adult (RPKM 7.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc66a1 in Genome Data Viewer
    Location:
    4 D3; 4 70.63 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (139021341..139038025, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (139294030..139310760, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 16287 Neighboring gene STARR-seq mESC enhancer starr_11823 Neighboring gene STARR-seq mESC enhancer starr_11824 Neighboring gene capping actin protein of muscle Z-line subunit beta Neighboring gene STARR-seq mESC enhancer starr_11826 Neighboring gene STARR-positive B cell enhancer ABC_E6244 Neighboring gene aldo-keto reductase family 7, member A5 Neighboring gene STARR-positive B cell enhancer mm9_chr4:138886553-138886854 Neighboring gene cyclin D3, pseudogene Neighboring gene mRNA turnover 4, ribosome maturation factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article
    2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC29170, MGC38094

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-arginine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-arginine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables L-histidine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-lysine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-lysine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-lysine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables basic amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables basic amino acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-arginine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-arginine transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in L-histidine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-lysine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-lysine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular amino acid homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular amino acid homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lysine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lysine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in organelle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in organelle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    lysosomal amino acid transporter 1 homolog
    Names
    PQ loop repeat containing 2
    PQ-loop repeat-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145384.4 → NP_663359.2  lysosomal amino acid transporter 1 homolog

      See identical proteins and their annotated locations for NP_663359.2

      Status: VALIDATED

      Source sequence(s)
      AL807811
      Consensus CDS
      CCDS18843.2
      UniProtKB/Swiss-Prot
      Q8C4N4, Q8R132
      Related
      ENSMUSP00000059772.6, ENSMUST00000053862.12
      Conserved Domains (1) summary
      pfam04193
      Location:37 → 98
      PQ-loop; PQ loop repeat

    RNA

    1. NR_151463.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL807811

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      139021341..139038025 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250219.4 → XP_011248521.1  lysosomal amino acid transporter 1 homolog isoform X1

      UniProtKB/TrEMBL
      A6PWV7, Q8VCS7
      Related
      ENSMUSP00000101427.3, ENSMUST00000105801.9
      Conserved Domains (1) summary
      pfam04193
      Location:37 → 98
      PQ-loop; PQ loop repeat

    RNA

    1. XR_003954901.2 RNA Sequence

    2. XR_003954904.2 RNA Sequence

    3. XR_003954903.2 RNA Sequence

    4. XR_003954902.2 RNA Sequence

    5. XR_004941859.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C4N4.1 GenPept UniProtKB/Swiss-Prot:Q8C4N4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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