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    Ccar1 cell division cycle and apoptosis regulator 1 [ Mus musculus (house mouse) ]

    Gene ID: 67500, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Ccar1provided by MGI
    Official Full Name
    cell division cycle and apoptosis regulator 1provided by MGI
    Primary source
    MGI:MGI:1914750
    See related
    Ensembl:ENSMUSG00000020074 AllianceGenome:MGI:1914750
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Carp1; 2610511G16Rik; 9430036H15Rik
    Summary
    Enables transcription coactivator activity. Predicted to be involved in positive regulation of cell migration; positive regulation of cell population proliferation; and regulation of DNA-templated transcription. Predicted to act upstream of or within positive regulation of apoptotic process. Predicted to be located in nuclear envelope lumen. Predicted to be active in nucleus. Is expressed in early conceptus; inner cell mass; and oocyte. Orthologous to human CCAR1 (cell division cycle and apoptosis regulator 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 29.0), CNS E14 (RPKM 18.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccar1 in Genome Data Viewer
    Location:
    10 B4; 10 32.47 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (62579707..62628147, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (62743928..62792368, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene storkhead box 1 Neighboring gene STARR-seq mESC enhancer starr_26891 Neighboring gene STARR-seq mESC enhancer starr_26892 Neighboring gene microRNA 7215 Neighboring gene NHP2 ribonucleoprotein pseudogene Neighboring gene STARR-seq mESC enhancer starr_26893 Neighboring gene small nucleolar RNA, C/D box 98 Neighboring gene STARR-seq mESC enhancer starr_26894 Neighboring gene tet methylcytosine dioxygenase 1 Neighboring gene STARR-seq mESC enhancer starr_26901 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:62328128-62328311 Neighboring gene STARR-seq mESC enhancer starr_26907 Neighboring gene predicted gene, 51805 Neighboring gene CRISPRi-validated Tet1 enhancer cluster Neighboring gene predicted gene, 26479

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Coregulator cell cycle and apoptosis regulator 1 (CCAR1) positively regulates adipocyte differentiation through the glucocorticoid signaling pathway. Ou CY, et al. J Biol Chem, 2014 Jun 13. PMID 24811171, Free PMC Article
    2. Cell cycle and apoptosis regulatory protein (CARP)-1 is expressed in osteoblasts and regulated by PTH. Sharma S, et al. Biochem Biophys Res Commun, 2013 Jul 12. PMID 23764399, Free PMC Article
    3. CCAR1 is required for Ngn3-mediated endocrine differentiation. Lu CK, et al. Biochem Biophys Res Commun, 2012 Feb 10. PMID 22266316
    4. Necdin enhances myoblasts survival by facilitating the degradation of the mediator of apoptosis CCAR1/CARP1. François S, et al. PLoS One, 2012. PMID 22905258, Free PMC Article
    5. CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes. Kim JH, et al. Mol Cell, 2008 Aug 22. PMID 18722177, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Depletion of CCAR1 compromised adipogenesis in cell culture and GR-mediated chromatin remodeling of PPARgamma gene enhancer elements.
      Title: Coregulator cell cycle and apoptosis regulator 1 (CCAR1) positively regulates adipocyte differentiation through the glucocorticoid signaling pathway.
    2. CCAR1 and CoCoA are a bypass between GATA1 and the MED1 subunit of Mediator
      Title: CCAR1/CoCoA pair-mediated recruitment of the Mediator defines a novel pathway for GATA1 function.
    3. studies identified CARP-1 for the first time in osteoblasts and suggest its potential role in PTH signaling and bone anabolic action
      Title: Cell cycle and apoptosis regulatory protein (CARP)-1 is expressed in osteoblasts and regulated by PTH.
    4. necdin exerts its pro-survival activity by counteracting the action of the pro-apoptotic protein Cell Cycle Apoptosis Regulatory Protein (CCAR1/CARP1)
      Title: Necdin enhances myoblasts survival by facilitating the degradation of the mediator of apoptosis CCAR1/CARP1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC90759

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear envelope lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cell division cycle and apoptosis regulator protein 1
    Names
    CARP-1
    cell cycle and apoptosis regulatory protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429504.1 → NP_001416433.1  cell division cycle and apoptosis regulator protein 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC122539
      UniProtKB/Swiss-Prot
      Q05BR1, Q05DK6, Q6AXC9, Q6PAR2, Q80XE4, Q8BJY0, Q8BVN2, Q8CGG1, Q8CH18, Q9CSR5

    2. NM_001429505.1 → NP_001416434.1  cell division cycle and apoptosis regulator protein 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC122539
      UniProtKB/Swiss-Prot
      Q05BR1, Q05DK6, Q6AXC9, Q6PAR2, Q80XE4, Q8BJY0, Q8BVN2, Q8CGG1, Q8CH18, Q9CSR5

    3. NM_001429506.1 → NP_001416435.1  cell division cycle and apoptosis regulator protein 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC122539

    4. NM_001429507.1 → NP_001416436.1  cell division cycle and apoptosis regulator protein 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC122539

    5. NM_001429508.1 → NP_001416437.1  cell division cycle and apoptosis regulator protein 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC122539

    6. NM_001429509.1 → NP_001416438.1  cell division cycle and apoptosis regulator protein 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC122539

    7. NM_001429510.1 → NP_001416439.1  cell division cycle and apoptosis regulator protein 1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC122539

    8. NM_001429511.1 → NP_001416440.1  cell division cycle and apoptosis regulator protein 1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC122539

    9. NM_026201.4 → NP_080477.1  cell division cycle and apoptosis regulator protein 1 isoform a

      See identical proteins and their annotated locations for NP_080477.1

      Status: VALIDATED

      Source sequence(s)
      AC122539
      Consensus CDS
      CCDS35922.1
      UniProtKB/Swiss-Prot
      Q05BR1, Q05DK6, Q6AXC9, Q6PAR2, Q80XE4, Q8BJY0, Q8BVN2, Q8CGG1, Q8CH18, Q9CSR5
      Related
      ENSMUSP00000151895.2, ENSMUST00000219527.2
      Conserved Domains (5) summary
      smart00513
      Location:634 → 667
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      PRK10927
      Location:184 → 303
      PRK10927; cell division protein FtsN
      TIGR04523
      Location:1034 → 1141
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam14443
      Location:479 → 598
      DBC1
      pfam14444
      Location:145 → 201
      S1-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      62579707..62628147 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513997.4 → XP_006514060.1  cell division cycle and apoptosis regulator protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q8CH18
      Conserved Domains (4) summary
      PRK10927
      Location:184 → 303
      PRK10927; cell division protein FtsN
      TIGR04523
      Location:972 → 1079
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam14443
      Location:476 → 601
      DBC1
      pfam14444
      Location:145 → 201
      S1-like

    2. XM_036155963.1 → XP_036011856.1  cell division cycle and apoptosis regulator protein 1 isoform X2

      Conserved Domains (4) summary
      PRK10927
      Location:184 → 303
      PRK10927; cell division protein FtsN
      TIGR04523
      Location:972 → 1079
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam14443
      Location:476 → 601
      DBC1
      pfam14444
      Location:145 → 201
      S1-like

    3. XM_006513996.4 → XP_006514059.1  cell division cycle and apoptosis regulator protein 1 isoform X1

      Conserved Domains (5) summary
      smart00513
      Location:634 → 667
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      PRK10927
      Location:184 → 303
      PRK10927; cell division protein FtsN
      TIGR04523
      Location:1034 → 1141
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam14443
      Location:479 → 598
      DBC1
      pfam14444
      Location:145 → 201
      S1-like

    4. XM_011243537.4 → XP_011241839.1  cell division cycle and apoptosis regulator protein 1 isoform X1

      Related
      ENSMUSP00000020268.6, ENSMUST00000020268.7
      Conserved Domains (5) summary
      smart00513
      Location:634 → 667
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      PRK10927
      Location:184 → 303
      PRK10927; cell division protein FtsN
      TIGR04523
      Location:1034 → 1141
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam14443
      Location:479 → 598
      DBC1
      pfam14444
      Location:145 → 201
      S1-like

    5. XM_006513994.5 → XP_006514057.1  cell division cycle and apoptosis regulator protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006514057.1

      UniProtKB/Swiss-Prot
      Q05BR1, Q05DK6, Q6AXC9, Q6PAR2, Q80XE4, Q8BJY0, Q8BVN2, Q8CGG1, Q8CH18, Q9CSR5
      Conserved Domains (5) summary
      smart00513
      Location:634 → 667
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      PRK10927
      Location:184 → 303
      PRK10927; cell division protein FtsN
      TIGR04523
      Location:1034 → 1141
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam14443
      Location:479 → 598
      DBC1
      pfam14444
      Location:145 → 201
      S1-like

    6. XM_006513995.4 → XP_006514058.1  cell division cycle and apoptosis regulator protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006514058.1

      UniProtKB/Swiss-Prot
      Q05BR1, Q05DK6, Q6AXC9, Q6PAR2, Q80XE4, Q8BJY0, Q8BVN2, Q8CGG1, Q8CH18, Q9CSR5
      Conserved Domains (5) summary
      smart00513
      Location:634 → 667
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      PRK10927
      Location:184 → 303
      PRK10927; cell division protein FtsN
      TIGR04523
      Location:1034 → 1141
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam14443
      Location:479 → 598
      DBC1
      pfam14444
      Location:145 → 201
      S1-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CH18.1 GenPept UniProtKB/Swiss-Prot:Q8CH18

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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