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    Zfp236 zinc finger protein 236 [ Mus musculus (house mouse) ]

    Gene ID: 329002, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Zfp236provided by MGI
    Official Full Name
    zinc finger protein 236provided by MGI
    Primary source
    MGI:MGI:1926950
    See related
    Ensembl:ENSMUSG00000041258 AllianceGenome:MGI:1926950
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm335
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in central nervous system; early conceptus; and genitourinary system. Orthologous to human ZNF236 (zinc finger protein 236). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 8.4), ovary adult (RPKM 4.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp236 in Genome Data Viewer
    Location:
    18 E3; 18 56.26 cM
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (82611718..82711044, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (82593593..82692915, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene myelin basic protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:82698694-82698847 Neighboring gene STARR-positive B cell enhancer ABC_E7619 Neighboring gene ribosomal protein L21, pseudogene 8 Neighboring gene STARR-seq mESC enhancer starr_45208 Neighboring gene predicted gene, 57823 Neighboring gene STARR-seq mESC enhancer starr_45213 Neighboring gene predicted gene 10524 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:82886249-82886432 Neighboring gene predicted gene, 50351 Neighboring gene microRNA 5112 Neighboring gene RIKEN cDNA 2210420H20 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identifying key m(6)A-methylated lncRNAs and genes associated with neural tube defects via integrative MeRIP and RNA sequencing analyses. Yang J, et al. Front Genet, 2022. PMID 36482889, Free PMC Article
    2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    3. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 236

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374229.1 → NP_001361158.1  zinc finger protein 236 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC119259, AC158975
      Consensus CDS
      CCDS89291.1
      UniProtKB/TrEMBL
      S4R299
      Related
      ENSMUSP00000138557.2, ENSMUST00000182122.8
      Conserved Domains (5) summary
      COG5048
      Location:653 → 1058
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:201 → 221
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1256 → 1276
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05109
      Location:1374 → 1675
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13465
      Location:1740 → 1764
      zf-H2C2_2; Zinc-finger double domain

    2. NM_177832.4 → NP_808500.2  zinc finger protein 236 isoform 2

      See identical proteins and their annotated locations for NP_808500.2

      Status: VALIDATED

      Source sequence(s)
      AC119259, AC158975
      Consensus CDS
      CCDS50337.1
      UniProtKB/TrEMBL
      B2RR24
      Related
      ENSMUSP00000130004.2, ENSMUST00000171071.9
      Conserved Domains (5) summary
      COG5048
      Location:605 → 1010
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:201 → 221
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1208 → 1228
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05109
      Location:1326 → 1627
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13465
      Location:1692 → 1716
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      82611718..82711044 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526494.5 → XP_006526557.1  zinc finger protein 236 isoform X3

      Conserved Domains (5) summary
      COG5048
      Location:653 → 1058
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:201 → 221
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1256 → 1276
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05109
      Location:1374 → 1569
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13465
      Location:1696 → 1720
      zf-H2C2_2; Zinc-finger double domain

    2. XM_036161185.1 → XP_036017078.1  zinc finger protein 236 isoform X4

      Conserved Domains (6) summary
      COG5048
      Location:596 → 1001
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:144 → 164
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1199 → 1219
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05109
      Location:1317 → 1618
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13465
      Location:1127 → 1151
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:1605 → 1653
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    3. XM_006526493.4 → XP_006526556.1  zinc finger protein 236 isoform X2

      Conserved Domains (5) summary
      COG5048
      Location:637 → 1042
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:185 → 205
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1240 → 1260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05109
      Location:1358 → 1659
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13465
      Location:1724 → 1748
      zf-H2C2_2; Zinc-finger double domain

    4. XM_006526492.5 → XP_006526555.1  zinc finger protein 236 isoform X1

      See identical proteins and their annotated locations for XP_006526555.1

      Conserved Domains (5) summary
      COG5048
      Location:646 → 1051
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:194 → 214
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1249 → 1269
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05109
      Location:1367 → 1668
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13465
      Location:1177 → 1201
      zf-H2C2_2; Zinc-finger double domain

    5. XM_017317934.3 → XP_017173423.1  zinc finger protein 236 isoform X6

      Conserved Domains (6) summary
      COG5048
      Location:212 → 617
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:731 → 751
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:815 → 835
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05109
      Location:933 → 1234
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00096
      Location:43 → 65
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1299 → 1323
      zf-H2C2_2; Zinc-finger double domain

    6. XM_017317933.3 → XP_017173422.1  zinc finger protein 236 isoform X4

      Conserved Domains (6) summary
      COG5048
      Location:596 → 1001
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:144 → 164
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1199 → 1219
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05109
      Location:1317 → 1618
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13465
      Location:1127 → 1151
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:1605 → 1653
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    7. XM_011247084.4 → XP_011245386.1  zinc finger protein 236 isoform X1

      See identical proteins and their annotated locations for XP_011245386.1

      Conserved Domains (5) summary
      COG5048
      Location:646 → 1051
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:194 → 214
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1249 → 1269
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05109
      Location:1367 → 1668
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13465
      Location:1177 → 1201
      zf-H2C2_2; Zinc-finger double domain

    8. XM_011247083.3 → XP_011245385.1  zinc finger protein 236 isoform X1

      See identical proteins and their annotated locations for XP_011245385.1

      Conserved Domains (5) summary
      COG5048
      Location:646 → 1051
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:194 → 214
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1249 → 1269
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05109
      Location:1367 → 1668
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13465
      Location:1177 → 1201
      zf-H2C2_2; Zinc-finger double domain

    9. XM_006526497.5 → XP_006526560.1  zinc finger protein 236 isoform X5

      See identical proteins and their annotated locations for XP_006526560.1

      Conserved Domains (5) summary
      COG5048
      Location:653 → 1058
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:201 → 221
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1256 → 1276
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1184 → 1208
      zf-H2C2_2; Zinc-finger double domain
      NF033208
      Location:1348 → 1533
      choice_anch_E; choice-of-anchor E domain-containing protein

    RNA

    1. XR_003952527.2 RNA Sequence

    2. XR_003952528.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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