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    GCV2 glycine decarboxylase subunit P [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855227, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GCV2
    Official Full Name
    glycine decarboxylase subunit P
    Primary source
    SGD:S000004801
    Locus tag
    YMR189W
    See related
    AllianceGenome:SGD:S000004801; FungiDB:YMR189W; VEuPathDB:YMR189W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GSD2
    Summary
    Enables glycine dehydrogenase (decarboxylating) activity. Involved in glycine decarboxylation via glycine cleavage system and one-carbon metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in glycine encephalopathy. Orthologous to human GLDC (glycine decarboxylase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GCV2 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (637500..640604)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mitochondrial 37S ribosomal protein MRPS17 Neighboring gene ATP-dependent DNA helicase SGS1 Neighboring gene Spg5p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Specific induction by glycine of the gene for the P-subunit of glycine decarboxylase from Saccharomyces cerevisiae. Sinclair DA, et al. Mol Microbiol, 1996 Feb. PMID 8830251
    2. "Active" one-carbon generation in Saccharomyces cerevisiae. Ogur M, et al. J Bacteriol, 1977 Feb. PMID 320197, Free PMC Article
    3. Regulation of the yeast glycine cleavage genes is responsive to the availability of multiple nutrients. Piper MD, et al. FEMS Yeast Res, 2002 Mar. PMID 12702322
    4. Control of expression of one-carbon metabolism genes of Saccharomyces cerevisiae is mediated by a tetrahydrofolate-responsive protein binding to a glycine regulatory region including a core 5'-CTTCTT-3' motif. Hong SP, et al. J Biol Chem, 1999 Apr 9. PMID 10187845
    5. Identification of a novel one-carbon metabolism regulon in Saccharomyces cerevisiae. Gelling CL, et al. J Biol Chem, 2004 Feb 20. PMID 14645232

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables glycine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycine dehydrogenase (decarboxylating) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycine dehydrogenase (decarboxylating) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycine dehydrogenase (decarboxylating) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycine decarboxylation via glycine cleavage system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycine decarboxylation via glycine cleavage system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in one-carbon metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of glycine cleavage complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glycine decarboxylase subunit P
    NP_013914.1
    • P subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      637500..640604
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182695.1 → NP_013914.1  TPA: glycine decarboxylase subunit P [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013914.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W013, P49095
      UniProtKB/TrEMBL
      A6ZMQ0, C7GRG2, C8ZF53, N1P5R9
      Conserved Domains (1) summary
      TIGR00461
      Location:70 → 1023
      gcvP; glycine dehydrogenase (decarboxylating)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49095.1

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