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    rpa49 DNA-directed RNA polymerase I complex subunit Rpa49 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541914, updated on 22-Jun-2024

    Summary

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    Gene symbol
    rpa49
    Gene description
    DNA-directed RNA polymerase I complex subunit Rpa49
    Locus tag
    SPOM_SPAC2F3.03C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    rpa51
    Old locus tag
    SPAC2F3.03c
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    Genomic context

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    See rpa49 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (3925533..3927279, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene translocation subcomplex subunit Sec72 Neighboring gene single-strand DNA-binding protein Rim1 Neighboring gene xylose and arabinose reductase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The fission yeast RPA51 is a functional homolog of the budding yeast A49 subunit of RNA polymerase I and required for maximizing transcription of ribosomal DNA. Nakagawa K, et al. Genes Genet Syst, 2003 Jun. PMID 12893961
    2. Structure-function analysis of Hmo1 unveils an ancestral organization of HMG-Box factors involved in ribosomal DNA transcription from yeast to human. Albert B, et al. Nucleic Acids Res, 2013 Dec. PMID 24021628, Free PMC Article
    3. Conserved strategies of RNA polymerase I hibernation and activation. Heiss FB, et al. Nat Commun, 2021 Feb 3. PMID 33536435, Free PMC Article
    4. Nucleocytoplasmic transport in the midzone membrane domain controls yeast mitotic spindle disassembly. Lucena R, et al. J Cell Biol, 2015 May 11. PMID 25963819, Free PMC Article
    5. Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries. Wang J, et al. Genes Dev, 2013 Sep 1. PMID 24013502, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Conserved strategies of RNA polymerase I hibernation and activation.
      Title: Conserved strategies of RNA polymerase I hibernation and activation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase I preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription elongation by RNA polymerase I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription elongation by RNA polymerase I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase I complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase I complex subunit Rpa49

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3925533..3927279 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019803.3 → NP_594382.1  DNA-directed RNA polymerase I complex subunit Rpa49 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594382.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14086
      Conserved Domains (1) summary
      pfam06870
      Location:47 → 423
      RNA_pol_I_A49; A49-like RNA polymerase I associated factor
    Nucleotide Protein
    Heading Accession and Version

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