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    SPH1 Sph1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851023, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SPH1
    Official Full Name
    Sph1p
    Primary source
    SGD:S000004305
    Locus tag
    YLR313C
    See related
    AllianceGenome:SGD:S000004305; FungiDB:YLR313C; VEuPathDB:YLR313C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YLR312C-B
    Summary
    Predicted to enable MAP-kinase scaffold activity. Involved in several processes, including bipolar cellular bud site selection; mating projection formation; and pseudohyphal growth. Located in cellular bud neck; cellular bud tip; and mating projection. Part of incipient cellular bud site. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SPH1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (760750..762342, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Atg39p Neighboring gene mitochondrial 54S ribosomal protein YmL15 Neighboring gene septin CDC3 Neighboring gene Nkp2p Neighboring gene Tad3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A small conserved domain in the yeast Spa2p is necessary and sufficient for its polarized localization. Arkowitz RA, et al. J Cell Biol, 1997 Jul 14. PMID 9214378, Free PMC Article
    2. Role of a ubiquitin-like modification in polarized morphogenesis. Dittmar GA, et al. Science, 2002 Mar 29. PMID 11923536
    3. The Spa2-related protein, Sph1p, is important for polarized growth in yeast. Roemer T, et al. J Cell Sci, 1998 Feb. PMID 9443897
    4. Phosphorylation of Bni4 by MAP kinases contributes to septum assembly during yeast cytokinesis. Pérez J, et al. FEMS Yeast Res, 2016 Sep. PMID 27400980
    5. Spa2p interacts with cell polarity proteins and signaling components involved in yeast cell morphogenesis. Sheu YJ, et al. Mol Cell Biol, 1998 Jul. PMID 9632790, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables MAP-kinase scaffold activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in bipolar cellular bud site selection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in bipolar cellular bud site selection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in invasive filamentous growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in invasive filamentous growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in pseudohyphal growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pseudohyphal growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actomyosin contractile ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell cortex of growing cell tip IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cellular bud neck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cellular bud tip IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in incipient cellular bud site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mating projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mating projection tip IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Sph1p
    NP_013417.3
    • Protein involved in shmoo formation and bipolar bud site selection; localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p; SPH1 has a paralog, SPA2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      760750..762342 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182202.2 → NP_013417.3  TPA: Sph1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013417.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5VNL2, N1NZL7
      Conserved Domains (2) summary
      smart00555
      Location:89 → 119
      GIT; Helical motif in the GIT family of ADP-ribosylation factor GTPase-activating proteins
      pfam15402
      Location:329 → 441
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
    Nucleotide Protein
    Heading Accession and Version

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