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    shk2 PAK-like kinase Shk2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541468, updated on 18-Sep-2024

    Summary

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    Official Symbol
    shk2
    Official Full Name
    PAK-like kinase Shk2
    Primary source
    PomBase:SPAC1F5.09c
    Locus tag
    SPOM_SPAC1F5.09C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    pak2
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    Genomic context

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    See shk2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (273152..274921)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ATP-dependent RNA helicase Neighboring gene plasma membrane stretch-activated calcium ion channel Yam8 Neighboring gene protein Lhs1 Neighboring gene protoporphyrinogen oxidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of Pak2p, a pleckstrin homology domain-containing, p21-activated protein kinase from fission yeast. Sells MA, et al. J Biol Chem, 1998 Jul 17. PMID 9660818
    2. Gamete fusion triggers bipartite transcription factor assembly to block re-fertilization. Vještica A, et al. Nature, 2018 Aug. PMID 30089908
    3. The Schizosaccharomyces pombe Cdc42p GTPase signals through Pak2p and the Mkh1p-Pek1p-Spm1p MAP kinase pathway. Merla A, et al. Curr Genet, 2001 Jun. PMID 11453249
    4. The novel Rho GTPase-activating protein family protein, Rga8, provides a potential link between Cdc42/p21-activated kinase and Rho signaling pathways in the fission yeast, Schizosaccharomyces pombe. Yang P, et al. J Biol Chem, 2003 Dec 5. PMID 14506270
    5. Cloning and characterization of shk2, a gene encoding a novel p21-activated protein kinase from fission yeast. Yang P, et al. J Biol Chem, 1998 Jul 17. PMID 9660817

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables lipid binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in plasma membrane fusion involved in cytogamy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    PAK-like kinase Shk2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      273152..274921
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018264.1 → NP_592864.1  PAK-like kinase Shk2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_592864.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q10056
      Conserved Domains (4) summary
      smart00220
      Location:309 → 566
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13279
      Location:24 → 120
      PH_Cla4_Ste20; Pleckstrin homology (PH) domain
      cd06614
      Location:308 → 567
      STKc_PAK; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase
      pfam00786
      Location:128 → 182
      PBD; P21-Rho-binding domain
    Nucleotide Protein
    Heading Accession and Version

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