swi6 heterochromatin (HP1) family chromodomain protein Swi6 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Official Symbol: swi6
Official Full Name: heterochromatin (HP1) family chromodomain protein Swi6
Primary source: PomBase:SPAC664.01c
Locus tag: SPOM_SPAC664.01C
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as: SPAC824.10c
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Genomic context

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See swi6 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 1

Sequence:: Chromosome: I; NC_003424.3 (1702406..1704098, complement)

Chromosome I - NC_003424.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TORC1 regulates G1/S transition and cell proliferation via the E2F homologs MBF and SBF in yeast.
Title: TORC1 regulates G1/S transition and cell proliferation via the E2F homologs MBF and SBF in yeast.
results indicate that Swi6 couples its oligomerization to the phase separation of chromatin by a counterintuitive mechanism, namely the dynamic exposure of buried nucleosomal regions; such reshaping of the octamer core by Swi6 increases opportunities for multivalent interactions between nucleosomes, thereby promoting phase separation; this mechanism may more generally drive chromatin organization beyond heterochromatin
Title: HP1 reshapes nucleosome core to promote phase separation of heterochromatin.
Swi6 interacts with Dfp1, a regulatory subunit of DBF4-dependent kinase (DDK), and failure to recruit Dfp1 to the pericentromere results in late DNA replication.
Title: Overlapping Roles in Chromosome Segregation for Heterochromatin Protein 1 (Swi6) and DDK in Schizosaccharomyces pombe.
The mechanism has been uncovered by which fission yeast heterochromatin protein Swi6 (mammalian HP1-homolog) prevents recruitment of activators of meiotic double-stranded breaks formation.
Title: Pericentromere-Specific Cohesin Complex Prevents Meiotic Pericentric DNA Double-Strand Breaks and Lethal Crossovers.
findings uncover quantitative differences in how Swi6 and Chp2 interact with nucleosomal and non-nucleosomal ligands and qualitative differences in how their assembly on nucleosomes is regulated
Title: Biochemical Basis for Distinct Roles of the Heterochromatin Proteins Swi6 and Chp2.
rather than promoting maintenance and spreading of heterochromatin, Swi6 appears to limit these processes and appropriately confine heterochromatin.
Title: H3K9 methylation extends across natural boundaries of heterochromatin in the absence of an HP1 protein.
Division of Labor between the Chromodomains of HP1/Swi6 and Suv39/Clr4 Is Required for Productive Heterochromatin Assembly.
Title: Division of labor between the chromodomains of HP1 and Suv39 methylase enables coordination of heterochromatin spread.
binding of HP1 protein, Swi6, to methylated nucleosomes drives a switch from an auto-inhibited state to a spreading-competent state, where H3K9-methylated heterochromatin spreads to adjacent regions
Title: A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly.
HP1(Swi6) mediates the recognition and destruction of heterochromatic RNA transcripts
Title: HP1(Swi6) mediates the recognition and destruction of heterochromatic RNA transcripts.
Ers1 may promote RNAi by tethering the corresponding enzyme complexes to HP1-coated chromatin, thereby placing them in proximity to the nascent noncoding RNA substrate
Title: Ers1 links HP1 to RNAi.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin-protein adaptor activity	EXP Inferred from Experiment more info	PubMed
enables chromatin-protein adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables chromatin-protein adaptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables histone reader activity	IDA Inferred from Direct Assay more info	PubMed
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in co-transcriptional gene silencing by RNA interference machinery	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in donor selection	IDA Inferred from Direct Assay more info	PubMed
involved_in gene conversion at mating-type locus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin boundary formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mating type switching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic centromeric cohesion protection in anaphase I	EXP Inferred from Experiment more info	PubMed
involved_in mitotic sister chromatid biorientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid cohesion, centromeric	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic telomere tethering at nuclear periphery	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pericentric heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in siRNA-mediated pericentric heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in silent mating-type cassette heterochromatin formation	EXP Inferred from Experiment more info	PubMed
involved_in silent mating-type cassette heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in subtelomeric heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in condensed chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
is_active_in heterochromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in heterochromatin island	IDA Inferred from Direct Assay more info	PubMed
is_active_in mating-type region heterochromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in pericentric heterochromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in pericentric heterochromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in subtelomeric heterochromatin	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: heterochromatin (HP1) family chromodomain protein Swi6

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003424.3 Reference assembly

Range

1702406..1704098 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001018882.3 → NP_593449.1 heterochromatin (HP1) family chromodomain protein Swi6 [Schizosaccharomyces pombe]

See identical proteins and their annotated locations for NP_593449.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

P40381

Conserved Domains (2) summary

smart00300
Location:261 → 326

ChSh; Chromo Shadow Domain

cd00024
Location:85 → 134

CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...