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    arg11 N-acetyl-gamma-glutamyl-phosphate reductase/acetylglutamate kinase [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543391, updated on 18-Sep-2024

    Summary

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    Official Symbol
    arg11
    Official Full Name
    N-acetyl-gamma-glutamyl-phosphate reductase/acetylglutamate kinase
    Primary source
    PomBase:SPAC4G9.09c
    Locus tag
    SPOM_SPAC4G9.09C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See arg11 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (2269908..2272724, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA-directed RNA polymerase III complex subunit Rpc2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ornithine carbamoyltransferase Arg3 Neighboring gene cytosine-mismatch-binding protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and sequencing of arg3 and arg11 genes of Schizosaccharomyces pombe on a 10-kb DNA fragment. Heterologous expression and mitochondrial targeting of their translation products. Van Huffel C, et al. Eur J Biochem, 1992 Apr 1. PMID 1313366
    2. Mitochondrial respiration is required to provide amino acids during fermentative proliferation of fission yeast. Malecki M, et al. EMBO Rep, 2020 Nov 5. PMID 32896087, Free PMC Article
    3. A central role for TOR signalling in a yeast model for juvenile CLN3 disease. Bond ME, et al. Microb Cell, 2015 Nov 11. PMID 28357272, Free PMC Article
    4. A non-transcriptional role for the glucocorticoid receptor in mediating the cell stress response. Ptushkina M, et al. Sci Rep, 2017 Sep 21. PMID 28935859, Free PMC Article
    5. Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex. Stewart EV, et al. Mol Cell, 2011 Apr 22. PMID 21504829, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acetyl-gamma-glutamyl-phosphate reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetyl-gamma-glutamyl-phosphate reductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP+ binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetylglutamate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-arginine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in arginine biosynthetic process via ornithine EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in arginine biosynthetic process via ornithine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    N-acetyl-gamma-glutamyl-phosphate reductase/acetylglutamate kinase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2269908..2272724 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019123.3 → NP_593691.1  N-acetyl-gamma-glutamyl-phosphate reductase/acetylglutamate kinase [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593691.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P31318
      Conserved Domains (6) summary
      PRK04531
      Location:60 → 489
      PRK04531; acetylglutamate kinase; Provisional
      cd04252
      Location:94 → 342
      AAK_NAGK-fArgBP; AAK_NAGK-fArgBP: N-Acetyl-L-glutamate kinase (NAGK) of the fungal arginine-biosynthetic pathway (fArgBP). The nuclear-encoded, mitochondrial polyprotein precursor with an N-terminal NAGK (ArgB) domain (this CD), a central DUF619 domain, and a C-terminal ...
      TIGR01850
      Location:572 → 882
      argC; N-acetyl-gamma-glutamyl-phosphate reductase, common form
      pfam01118
      Location:575 → 695
      Semialdhyde_dh; Semialdehyde dehydrogenase, NAD binding domain
      pfam04768
      Location:327 → 494
      NAT; NAT, N-acetyltransferase, of N-acetylglutamate synthase
      cl19935
      Location:712 → 860
      Gp_dh_C; Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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