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    wis4 MAP kinase kinase kinase Wis4 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542873, updated on 18-Sep-2024

    Summary

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    Official Symbol
    wis4
    Official Full Name
    MAP kinase kinase kinase Wis4
    Primary source
    PomBase:SPAC9G1.02
    Locus tag
    SPOM_SPAC9G1.02
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    wak1; wik1
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    Genomic context

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    See wis4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (1968857..1973575)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Vid24 family vesicle protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 60S ribosomal protein eL30 Neighboring gene ncRNA Neighboring gene translocase Oxa101

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Heat stress activates fission yeast Spc1/StyI MAPK by a MEKK-independent mechanism. Shiozaki K, et al. Mol Biol Cell, 1998 Jun. PMID 9614178, Free PMC Article
    2. Azoles activate Atf1-mediated transcription through MAP kinase pathway for antifungal effects in fission yeast. Hu L, et al. Genes Cells, 2015 Sep. PMID 26108447
    3. Evidence for a novel MAPKKK-independent pathway controlling the stress activated Sty1/Spc1 MAP kinase in fission yeast. Shieh JC, et al. J Cell Sci, 1998 Sep. PMID 9718372
    4. Multiple modes of activation of the stress-responsive MAP kinase pathway in fission yeast. Samejima I, et al. EMBO J, 1997 Oct 15. PMID 9321395, Free PMC Article
    5. The Win1 mitotic regulator is a component of the fission yeast stress-activated Sty1 MAPK pathway. Shieh JC, et al. Mol Biol Cell, 1998 Feb. PMID 9450957, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that Mcs4 is required for stable heteromer formation between the Wis4 and Win1 MAPKKKs.
      Title: Response regulator-mediated MAPKKK heteromer promotes stress signaling to the Spc1 MAPK in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables MAP kinase kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables MAP kinase kinase kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in p38MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in p38MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in p38MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Mcs4 RR-MAPKKK complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Mcs4 RR-MAPKKK complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytoplasm HDA PubMed 
    is_active_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    MAP kinase kinase kinase Wis4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1968857..1973575
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018990.3 → NP_593557.1  MAP kinase kinase kinase Wis4 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593557.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14299, P87062, Q92384
      Conserved Domains (2) summary
      smart00220
      Location:1037 → 1306
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06626
      Location:1036 → 1306
      STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4
    Nucleotide Protein
    Heading Accession and Version

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