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    atl1 alkyltransferase-like protein Atl1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541704, updated on 18-Sep-2024

    Summary

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    Official Symbol
    atl1
    Official Full Name
    alkyltransferase-like protein Atl1
    Primary source
    PomBase:SPAC1250.04c
    Locus tag
    SPOM_SPAC1250.04C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See atl1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (5096895..5097662)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ubiquitin conjugating enzyme Ubc14 Neighboring gene TFIIIC subunit Sfc7 Neighboring gene ncRNA Neighboring gene protein mug95

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel DNA damage recognition protein in Schizosaccharomyces pombe. Pearson SJ, et al. Nucleic Acids Res, 2006. PMID 16679453, Free PMC Article
    2. Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation-π interactions. Wilkinson OJ, et al. Proc Natl Acad Sci U S A, 2012 Nov 13. PMID 23112169, Free PMC Article
    3. Flipping of alkylated DNA damage bridges base and nucleotide excision repair. Tubbs JL, et al. Nature, 2009 Jun 11. PMID 19516334, Free PMC Article
    4. Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines. Latypov VF, et al. Mol Cell, 2012 Jul 13. PMID 22658721, Free PMC Article
    5. A central role for TOR signalling in a yeast model for juvenile CLN3 disease. Bond ME, et al. Microb Cell, 2015 Nov 11. PMID 28357272, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation-pi interactions.
      Title: Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation-π interactions.
    2. Data show that alkyltransferase-like 1 (Atl1)can play a pivotal role in selecting a specific nucleotide excision repair (NER) pathway, depending on the nature of the DNA modification.
      Title: Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines.
    3. Schizosaccharomyces pombe ATL structures without and with damaged DNA containing the endogenous lesion O(6)-methylguanine or cigarette-smoke-derived O(6)-4-(3-pyridyl)-4-oxobutylguanine
      Title: Flipping of alkylated DNA damage bridges base and nucleotide excision repair.
    4. Atl1 may act by binding to O6-alkylguanine lesions and signalling them for processing by DNA repair pathways.
      Title: A novel DNA damage recognition protein in Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables O6-alkylguanine-DNA binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables O6-alkylguanine-DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables damaged DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables methylated-DNA-[protein]-cysteine S-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in global genome nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription-coupled nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    alkyltransferase-like protein Atl1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      5096895..5097662
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020287.3 → NP_594858.1  alkyltransferase-like protein Atl1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594858.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9UTN9
      Conserved Domains (2) summary
      COG0350
      Location:5 → 87
      AdaB; O6-methylguanine-DNA--protein-cysteine methyltransferase [Replication, recombination and repair]
      COG3695
      Location:1 → 108
      Atl1; Alkylated DNA nucleotide flippase Atl1, participates in nucleotide excision repair, Ada-like DNA-binding domain [Transcription]
    Nucleotide Protein
    Heading Accession and Version

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