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    SRL3 DNA-binding protein SRL3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853966, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SRL3
    Official Full Name
    DNA-binding protein SRL3
    Primary source
    SGD:S000001799
    Locus tag
    YKR091W
    See related
    AllianceGenome:SGD:S000001799; FungiDB:YKR091W; VEuPathDB:YKR091W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    WHI7
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in nucleobase-containing compound metabolic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SRL3 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (611525..612265)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene triacylglycerol lipase Neighboring gene Pxl1p Neighboring gene Srp40p Neighboring gene Ptr2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The budding yeast Start repressor Whi7 differs in regulation from Whi5, emerging as a major cell cycle brake in response to stress. Méndez E, et al. J Cell Sci, 2020 Dec 21. PMID 33443080, Free PMC Article
    2. The available SRL3 deletion strain of Saccharomyces cerevisiae contains a truncation of DNA damage tolerance protein Mms2: Implications for Srl3 and Mms2 functions. Kim E, et al. Internet J Microbiol, 2009. PMID 24795789, Free PMC Article
    3. Mitochondrial phosphatidylethanolamine synthesis affects mitochondrial energy metabolism and quiescence entry through attenuation of Snf1/AMPK signaling in yeast. Miyata N, et al. FASEB J, 2022 Jul. PMID 35639425
    4. Repression of G1/S transcription is mediated via interaction of the GTB motifs of Nrm1 and Whi5 with Swi6. Travesa A, et al. Mol Cell Biol, 2013 Apr. PMID 23382076, Free PMC Article
    5. Whi7 is an unstable cell-cycle repressor of the Start transcriptional program. Gomar-Alba M, et al. Nat Commun, 2017 Aug 24. PMID 28839131, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The CDK Pho85 inhibits Whi7 Start repressor to promote cell cycle entry in budding yeast.
      Title: The CDK Pho85 inhibits Whi7 Start repressor to promote cell cycle entry in budding yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleobase-containing compound metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SBF transcription complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding protein SRL3
    NP_013017.2
    • Transcriptional repressor at START; binds to SBF (Swi4p-Swi6p) at SCB promoter elements in G1 to repress transcription; START inhibitor that retains Cdc28-Cln3 at the ER; acts with Ydj1p to promote release of the complex in a growth-mediated positive feedback loop to trigger START; unstable and degraded by SCF-Grr1 after phosphorylation; contains a G1/S transcription factor binding (GTB) motif; binds SBF-regulated promoters in HU-treated cells; substrate of Cdc28p and Pho85p; hyperphosphorylated

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      611525..612265
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179881.1 → NP_013017.2  TPA: DNA-binding protein SRL3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013017.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXF1, P36167
      UniProtKB/TrEMBL
      G2WIB8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36167.2

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