U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    FRO1 NADH-ubiquinone oxidoreductase-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836895, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    FRO1
    Official Full Name
    NADH-ubiquinone oxidoreductase-like protein
    Primary source
    TAIR:AT5G67590
    Locus tag
    AT5G67590
    See related
    Araport:AT5G67590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    FROSTBITE1; K9I9.16; K9I9_16
    Summary
    Mutant leaves have a reduced capacity for cold acclimation, appear water-soaked, leak electrolytes, and accumulate reactive oxygen species constitutively. Encode a protein with high similarity to the 18-kD Fe-S subunit of complex I (NADH dehydrogenase, EC 1.6.5.3) in the mitochondrial electron transfer chain.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See FRO1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (26957915..26959557)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene Homeodomain-like/winged-helix DNA-binding family protein Neighboring gene cysteine-rich TM module stress tolerance protein Neighboring gene transmembrane protein (DUF2215) Neighboring gene DUF4228 domain protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Nitrogen Source Dependent Changes in Central Sugar Metabolism Maintain Cell Wall Assembly in Mitochondrial Complex I-Defective frostbite1 and Secondarily Affect Programmed Cell Death. Podgórska A, et al. Int J Mol Sci, 2018 Jul 28. PMID 30060552, Free PMC Article
    2. In comparison with nitrate nutrition, ammonium nutrition increases growth of the frostbite1 Arabidopsis mutant. Podgórska A, et al. Plant Cell Environ, 2015 Jan. PMID 25040883
    3. Complete Mitochondrial Complex I Deficiency Induces an Up-Regulation of Respiratory Fluxes That Is Abolished by Traces of Functional Complex I. Kühn K, et al. Plant Physiol, 2015 Aug. PMID 26134164, Free PMC Article
    4. A mitochondrial complex I defect impairs cold-regulated nuclear gene expression. Lee BH, et al. Plant Cell, 2002 Jun. PMID 12084824, Free PMC Article
    5. Dual location of the mitochondrial preprotein transporters B14.7 and Tim23-2 in complex I and the TIM17:23 complex in Arabidopsis links mitochondrial activity and biogenesis. Wang Y, et al. Plant Cell, 2012 Jun. PMID 22730406, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mitochondrial perturbations related to a defect in complex I in the Arabidopsis thaliana frostbite1 (fro1) mutant, carrying a point mutation in the 8-kD Fe-S subunit of NDUFS4 protein, alter aspects of fundamental carbon metabolism, which is manifested as stunted growth. The responses of fro1 plants to NH treatment were consistent with the inhibition of a form of programmed cell death.
      Title: Nitrogen Source Dependent Changes in Central Sugar Metabolism Maintain Cell Wall Assembly in Mitochondrial Complex I-Defective frostbite1 and Secondarily Affect Programmed Cell Death.
    2. Data show no major differences in the mitochondrial proteomes, cellular metabolomes, or transcriptomes between ndufv1 (At5g08530) and ndufs4 (At5g67590) mutants.
      Title: Complete Mitochondrial Complex I Deficiency Induces an Up-Regulation of Respiratory Fluxes That Is Abolished by Traces of Functional Complex I.
    3. The growth of fro1 plants increased under ammonium nutrition. Ammonium nutrition increased the reduction level of pyridine nucleotides in the leaves of wild-type plants, but not in the leaves of fro1 mutant plants.
      Title: In comparison with nitrate nutrition, ammonium nutrition increases growth of the frostbite1 Arabidopsis mutant.
    4. Removal of the single protein subunit NDUFS4 prevents assembly of complex I of the respiratory chain and removes its function from mitochondria without pleiotropic effects on other respiratory components. [NDUFS4]
      Title: Remodeled respiration in ndufs4 with low phosphorylation efficiency suppresses Arabidopsis germination and growth and alters control of metabolism at night.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_126159.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NADH dehydrogenase (ubiquinone) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables cobalt ion binding HDA PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cold acclimation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in electron transport chain IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid HDA PubMed 
    part_of respiratory chain complex I HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    NADH-ubiquinone oxidoreductase-like protein
    NP_201560.1
    • FROSTBITE1 (FRO1); CONTAINS InterPro DOMAIN/s: ETC complex I subunit conserved region (InterPro:IPR006885); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      26957915..26959557
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_126159.4 → NP_201560.1  NADH-ubiquinone oxidoreductase-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201560.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LC28, Q9FJW4
      UniProtKB/TrEMBL
      A0A178UKD2, A0A5S9YHW4
      Conserved Domains (1) summary
      pfam04800
      Location:53 → 149
      ETC_C1_NDUFA4; ETC complex I subunit conserved region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FJW4.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools