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    TRB2 Homeodomain-like/winged-helix DNA-binding family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836894, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TRB2
    Official Full Name
    Homeodomain-like/winged-helix DNA-binding family protein
    Primary source
    TAIR:AT5G67580
    Locus tag
    AT5G67580
    See related
    Araport:AT5G67580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATTBP3; ATTRB2; K9I9.15; K9I9_15; TBP3; TELOMERE REPEAT BINDING FACTOR 2; TELOMERE-BINDING PROTEIN 3
    Summary
    Encodes a telomeric DNA binding protein. In vitro, the protein preferentially binds double-stranded telomeric repeats, but it can also bind to the single G-rich telomeric strand.
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    Genomic context

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    See TRB2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (26955568..26957774, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor-like A1D Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene NADH-ubiquinone oxidoreductase-like protein Neighboring gene cysteine-rich TM module stress tolerance protein Neighboring gene transmembrane protein (DUF2215)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Solution structure of telomere binding domain of AtTRB2 derived from Arabidopsis thaliana. Yun JH, et al. Biochem Biophys Res Commun, 2014 Sep 26. PMID 25172657
    2. DNA-binding domain of AtTRB2 reveals unique features of a single Myb histone protein family that binds to both Arabidopsis- and human-type telomeric DNA sequences. Lee WK, et al. Mol Plant, 2012 Nov. PMID 22859734
    3. Telomere-binding protein regulates the chromosome ends through the interaction with histone deacetylases in Arabidopsis thaliana. Lee WK, et al. Nucleic Acids Res, 2016 Jun 2. PMID 26857545, Free PMC Article
    4. AtTRB1, a telomeric DNA-binding protein from Arabidopsis, is concentrated in the nucleolus and shows highly dynamic association with chromatin. Dvorácková M, et al. Plant J, 2010 Feb. PMID 19947985
    5. Characterization of two Arabidopsis thaliana myb-like proteins showing affinity to telomeric DNA sequence. Schrumpfová P, et al. Genome, 2004 Apr. PMID 15060584

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRB2 interacts with HD2-type histone deacetylase HDT4.TRB2 has a role in the regulation of telomeric chromatin.
      Title: Telomere-binding protein regulates the chromosome ends through the interaction with histone deacetylases in Arabidopsis thaliana.
    2. Trp28, Arg29, and Val47 residues located in Helix 2 and Helix 3 of TRB2 are crucial for DNA binding, and are well conserved among other plant telomere binding proteins.
      Title: Solution structure of telomere binding domain of AtTRB2 derived from Arabidopsis thaliana.
    3. structure and function of AtTRB2 protein
      Title: DNA-binding domain of AtTRB2 reveals unique features of a single Myb histone protein family that binds to both Arabidopsis- and human-type telomeric DNA sequences.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_126158.3
    NM_180955.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables double-stranded telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Homeodomain-like/winged-helix DNA-binding family protein
    NP_201559.1
    • TRB2; FUNCTIONS IN: single-stranded telomeric DNA binding, DNA binding, protein homodimerization activity, sequence-specific DNA binding transcription factor activity, double-stranded telomeric DNA binding; INVOLVED IN: in 8 processes; LOCATED IN: nucleus, nucleosome; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), SANT, DNA-binding (InterPro:IPR001005), Myb, DNA-binding (InterPro:IPR014778), Homeodomain-like (InterPro:IPR009057), Histone H1/H5 (InterPro:IPR005818), Homeodomain-related (InterPro:IPR012287), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930); BEST Arabidopsis thaliana protein match is: telomere repeat binding factor 3 (TAIR:AT3G49850.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
    NP_851286.1
    • TRB2; FUNCTIONS IN: single-stranded telomeric DNA binding, DNA binding, protein homodimerization activity, sequence-specific DNA binding transcription factor activity, double-stranded telomeric DNA binding; INVOLVED IN: in 8 processes; LOCATED IN: nucleus, nucleosome; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), SANT, DNA-binding (InterPro:IPR001005), Myb, DNA-binding (InterPro:IPR014778), Homeodomain-like (InterPro:IPR009057), Histone H1/H5 (InterPro:IPR005818), Homeodomain-related (InterPro:IPR012287), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930); BEST Arabidopsis thaliana protein match is: telomere repeat binding factor 3 (TAIR:AT3G49850.1); Has 792 Blast hits to 790 proteins in 134 species: Archae - 0; Bacteria - 2; Metazoa - 127; Fungi - 75; Plants - 516; Viruses - 0; Other Eukaryotes - 72 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      26955568..26957774 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180955.3 → NP_851286.1  Homeodomain-like/winged-helix DNA-binding family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851286.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8VX38, Q9FJW5
      UniProtKB/TrEMBL
      A0A178UR21, A0A5S9YI56
      Conserved Domains (3) summary
      smart00526
      Location:119 → 183
      H15; Domain in histone families 1 and 5
      smart00717
      Location:5 → 56
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11660
      Location:6 → 56
      SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family

    2. NM_126158.3 → NP_201559.1  Homeodomain-like/winged-helix DNA-binding family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201559.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8VX38, Q9FJW5
      UniProtKB/TrEMBL
      A0A178UR21, A0A5S9YI56
      Conserved Domains (3) summary
      smart00526
      Location:119 → 183
      H15; Domain in histone families 1 and 5
      smart00717
      Location:5 → 56
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11660
      Location:6 → 56
      SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FJW5.1

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