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    ARF4 auxin response factor 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836166, updated on 7-Sep-2023

    Summary

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    Gene symbol
    ARF4
    Gene description
    auxin response factor 4
    Primary source
    Araport:AT5G60450
    Locus tag
    AT5G60450
    See related
    TAIR:AT5G60450
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    auxin response factor 4; MUF9.7; MUF9_7
    Summary
    Encodes a member of the ARF family of transcription factors which mediate auxin responses. ARF4 appears to have redundant function with ETT(ARF3) in specifying abaxial cell identity.
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    Genomic context

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    See ARF4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    13
    Sequence:
    Chromosome: 5; NC_003076.8 (24308255..24312784, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene antiporter/ drug transporter Neighboring gene AGAMOUS-like 62 Neighboring gene Preprotein translocase Sec, Sec61-beta subunit protein Neighboring gene C2H2 and C2HC zinc fingers superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Trans-acting siRNA-mediated repression of ETTIN and ARF4 regulates heteroblasty in Arabidopsis. Hunter C, et al. Development, 2006 Aug. PMID 16818444, Free PMC Article
    2. ARF4 regulates shoot regeneration through coordination with ARF5 and IAA12. Zhang MM, et al. Plant Cell Rep, 2021 Feb. PMID 33180161
    3. ARF2-ARF4 and ARF5 are Essential for Female and Male Gametophyte Development in Arabidopsis. Liu Z, et al. Plant Cell Physiol, 2018 Jan 1. PMID 29145642
    4. Auxin response factors mediate Arabidopsis organ asymmetry via modulation of KANADI activity. Pekker I, et al. Plant Cell, 2005 Nov. PMID 16199616, Free PMC Article
    5. A gain-of-function mutation in IAA8 alters Arabidopsis floral organ development by change of jasmonic acid level. Wang J, et al. Plant Mol Biol, 2013 May. PMID 23483289

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ARF4 regulates shoot regeneration through coordination with ARF5 and IAA12.
      Title: ARF4 regulates shoot regeneration through coordination with ARF5 and IAA12.
    2. Results indicate that auxin response factors AtARF2-AtARF4 and AtARF5 play significant roles in regulating both female and male gametophyte development.
      Title: ARF2-ARF4 and ARF5 are Essential for Female and Male Gametophyte Development in Arabidopsis.
    3. regulation establishes the threshold at which leaves respond to a temporal signal, rather than being a component of this signal.
      Title: Trans-acting siRNA-mediated repression of ETTIN and ARF4 regulates heteroblasty in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Miscellaneous features

    • Loc: c24312539-24312456 AT5G60450.uORF1
    NM_125438.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within abaxial cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vegetative phase change IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    auxin response factor 4
    NP_200853.1
    • auxin response factor 4 (ARF4); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity; INVOLVED IN: vegetative phase change, regulation of transcription, DNA-dependent, abaxial cell fate specification; LOCATED IN: nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Aux/IAA-ARF-dimerisation (InterPro:IPR011525), Transcriptional factor B3 (InterPro:IPR003340), AUX/IAA protein (InterPro:IPR003311), Auxin response factor (InterPro:IPR010525); BEST Arabidopsis thaliana protein match is: Transcriptional factor B3 family protein / auxin-responsive factor AUX/IAA-related (TAIR:AT2G33860.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      24308255..24312784 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001345418.1 → NP_001331788.1  auxin response factor 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BF20, A0A7G2FJJ2

    2. NM_125438.4 → NP_200853.1  auxin response factor 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200853.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9ZTX9
      UniProtKB/TrEMBL
      A0A178ULQ0, A0A654GCU3
      Conserved Domains (3) summary
      pfam02309
      Location:636 → 735
      AUX_IAA; AUX/IAA family
      pfam02362
      Location:177 → 278
      B3; B3 DNA binding domain
      pfam06507
      Location:302 → 383
      Auxin_resp; Auxin response factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZTX9.1

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