SUMO1 small ubiquitin-like modifier 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: SUMO1
Gene description: small ubiquitin-like modifier 1
Primary source: Araport:AT4G26840
Locus tag: AT4G26840
See related: TAIR:AT4G26840
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA SMALL UBIQUITIN-LIKE MODIFIER 1; ATSUMO1; F10M23.180; F10M23_180; small ubiquitin-like modifier 1; SMALL UBIQUITIN-LIKE MODIFIER 1; SUM1; SUMO 1
Summary: Encodes a small ubiquitin-like modifier (SUMO) polypeptide that becomes covalently attached to various intracellular protein targets, much like ubiquitination, leading to post-translational modification of those targets.
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Genomic context

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See SUMO1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 3

Sequence:: Chromosome: 4; NC_003075.7 (13497287..13498820)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SUMO Conjugation to BZR1 Enables Brassinosteroid Signaling to Integrate Environmental Cues to Shape Plant Growth.
Title: SUMO Conjugation to BZR1 Enables Brassinosteroid Signaling to Integrate Environmental Cues to Shape Plant Growth.
The study provides an insight into the molecular mechanism for understanding how the CHD3-like chromatin remodeling protein MOM1 cooperates with the SUMO E3 ligase-like proteins to regulate transcriptional silencing. [SUMO1]
Title: Exploring potential roles for the interaction of MOM1 with SUMO and the SUMO E3 ligase-like protein PIAL2 in transcriptional silencing.
Bacterial flagellin induces the conjugation of the SMALL UBIQUITIN-LIKE MODIFIER (SUMO) protein to FLS2 to trigger release of BIK1 resulting in resistant to bacterial pathogens in Arabidopsis.
Title: SUMO conjugation to the pattern recognition receptor FLS2 triggers intracellular signalling in plant innate immunity.
SUMO chain formation relies on the amino-terminal region of SCE1 and has dedicated substrates in plants.
Title: SUMO chain formation relies on the amino-terminal region of SUMO-conjugating enzyme and has dedicated substrates in plants.
Functionally similar to human SUMO2 and SUMO3, Arabidopsis SUMO1 and 2 can form chains, even though they do not possess a consensus SUMOylation motif. The surprising finding that plants have dedicated enzymes for chain synthesis implies a specific role for SUMO chains in plants
Title: SUMO Chain Formation by Plant Enzymes.
we provide evidence for the existence of a preferential conjugation of AtSUMO1/2 compared with AtSUMO3/5, which is determined by a role of the E1-activating enzyme in SUMO paralogue discrimination.
Title: Distinctive properties of Arabidopsis SUMO paralogues support the in vivo predominant role of AtSUMO1/2 isoforms.
SUMO1 becomes conjugated with ubiquitin during heat stress, showing posttranslational modifications.
Title: Proteomic analyses identify a diverse array of nuclear processes affected by small ubiquitin-like modifier conjugation in Arabidopsis.
SUM3 promotes plant defense downstream of salicylic acid, while SUM1 and SUM2 together prevent salicylic acid accumulation in noninfected plants.
Title: Arabidopsis small ubiquitin-like modifier paralogs have distinct functions in development and defense.
SIZ1-mediated conjugation of SUMO1 and SUMO2 to other intracellular proteins is essential in Arabidopsis, possibly through stress-induced modification of a potentially diverse pool of nuclear proteins.
Title: Genetic analysis of SUMOylation in Arabidopsis: conjugation of SUMO1 and SUMO2 to nuclear proteins is essential.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_118818.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tag activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in heat acclimation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein sumoylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein sumoylation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to heat	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: small ubiquitin-like modifier 1

NP_194414.1

small ubiquitin-like modifier 1 (SUMO1); CONTAINS InterPro DOMAIN/s: Ubiquitin (InterPro:IPR000626), Ubiquitin supergroup (InterPro:IPR019955); BEST Arabidopsis thaliana protein match is: small ubiquitin-like modifier 2 (TAIR:AT5G55160.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

13497287..13498820

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_118818.4 → NP_194414.1 small ubiquitin-like modifier 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_194414.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P55852, Q547B9, Q9SZ24

UniProtKB/TrEMBL

A0A178V333, A0A5S9XWV8, A0A7G2F0Y1

Conserved Domains (1) summary

cd16116
Location:16 → 89

Ubl_Smt3_like; ubiquitin-like (Ubl) domain found in Saccharomyces cerevisiae ubiquitin-like protein Smt3p and similar proteins