GAPC1 glyceraldehyde-3-phosphate dehydrogenase C subunit 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: GAPC1
Official Full Name: glyceraldehyde-3-phosphate dehydrogenase C subunit 1
Primary source: TAIR:AT3G04120
Locus tag: AT3G04120
See related: Araport:AT3G04120
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: GAPC; GAPC-1; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE C SUBUNIT; glyceraldehyde-3-phosphate dehydrogenase C subunit 1; T6K12.26; T6K12_26
Summary: encodes cytosolic GADPH (C subunit) involved in the glycolytic pathway but also interacts with H2O2 potentially placing it in a signalling cascade induced by ROS.
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See GAPC1 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 9

Sequence:: Chromosome: 3; NC_003074.8 (1080942..1083690)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the redox-dependent localization of GapC1 and GapC2 in the different cellular subcompartments and their interactions with VDAC3 and Trx-h3
Title: Cytosolic GAPDH as a redox-dependent regulator of energy metabolism.
The E3 ubiquitin-ligase SEVEN IN ABSENTIA like 7 mono-ubiquitinates GAPC1 in vitro and is required for its nuclear localization.
Title: The E3 ubiquitin-ligase SEVEN IN ABSENTIA like 7 mono-ubiquitinates glyceraldehyde-3-phosphate dehydrogenase 1 isoform in vitro and is required for its nuclear localization in Arabidopsis thaliana.
After perception of bacterial flagellin, GAPC1 dynamically responded with a significant increase in size of fluorescent puncta and enhanced nuclear accumulation
Title: Beyond glycolysis: GAPDHs are multi-functional enzymes involved in regulation of ROS, autophagy, and plant immune responses.
FERONIA controls leaf starch accumulation by interacting with GAPC1.
Title: Receptor protein kinase FERONIA controls leaf starch accumulation by interacting with glyceraldehyde-3-phosphate dehydrogenase.
GAPC levels play important roles in the overall cellular production of reductants, energy, and carbohydrate metabolites and that GAPC levels are directly correlated with seed oil accumulation.
Title: Cytosolic phosphorylating glyceraldehyde-3-phosphate dehydrogenases affect Arabidopsis cellular metabolism and promote seed oil accumulation.
Glycolytic GAPC1, through its high sensitivity to the cellular redox state, may play a role in oxidative stress signaling or protection in plants.
Title: Nuclear accumulation of cytosolic glyceraldehyde-3-phosphate dehydrogenase in cadmium-stressed Arabidopsis roots.
Results indicate that the H(2)O(2)-promoted interaction of GAPC and PLDdelta may provide a direct connection between membrane lipid-based signaling, energy metabolism and growth control in the plant response to ROS and water stress.
Title: Cytosolic glyceraldehyde-3-phosphate dehydrogenases interact with phospholipase Dδ to transduce hydrogen peroxide signals in the Arabidopsis response to stress.
The addition of GSSG, and much more efficiently of S-nitrosoglutathione, was shown to inactivate the enzymes GapC1 and GapC2 from Arabidopsis thaliana, spinach, yeast and rabbit muscle. [GapC1]
Title: Regulation of plant cytosolic glyceraldehyde 3-phosphate dehydrogenase isoforms by thiol modifications.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

NM_111283.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables copper ion binding	HDA more info	PubMed
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	TAS Traceable Author Statement more info	PubMed
enables glyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables salicylic acid binding	HDA more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within fruit development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gluconeogenesis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within glycolytic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycolytic process	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to heat	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to hydrogen peroxide	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to redox state	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to sucrose	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within seed development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
NOT located_in Golgi apparatus	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in apoplast	HDA more info	PubMed
located_in chloroplast	HDA more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info	PubMed
located_in mitochondrial envelope	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: glyceraldehyde-3-phosphate dehydrogenase C subunit 1

NP_187062.1

glyceraldehyde-3-phosphate dehydrogenase C subunit 1 (GAPC1); FUNCTIONS IN: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity, copper ion binding, glyceraldehyde-3-phosphate dehydrogenase activity; INVOLVED IN: in 11 processes; LOCATED IN: in 8 components; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Glyceraldehyde 3-phosphate dehydrogenase family (InterPro:IPR020831), Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain (InterPro:IPR020829), Glyceraldehyde 3-phosphate dehydrogenase subfamily (InterPro:IPR000173), Glyceraldehyde-3-phosphate dehydrogenase, type I (InterPro:IPR006424), Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain, subgroup (InterPro:IPR020832), Glyceraldehyde 3-phosphate dehydrogenase, active site (InterPro:IPR020830), Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain (InterPro:IPR020828); BEST Arabidopsis thaliana protein match is: glyceraldehyde-3-phosphate dehydrogenase C2 (TAIR:AT1G13440.1); Has 25372 Blast hits to 25360 proteins in 6350 species: Archae - 71; Bacteria - 10995; Metazoa - 2358; Fungi - 2851; Plants - 3864; Viruses - 0; Other Eukaryotes - 5233 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

1080942..1083690

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_111283.4 → NP_187062.1 glyceraldehyde-3-phosphate dehydrogenase C subunit 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_187062.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P25858, Q0WVE7, Q42352, Q8LAS0, Q9M8W8

UniProtKB/TrEMBL

A0A5S9X911, A0A654F3Y9

Conserved Domains (1) summary

PLN02358
Location:1 → 338

PLN02358; glyceraldehyde-3-phosphate dehydrogenase