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    DEK1 calpain-type cysteine protease family [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841981, updated on 18-Sep-2024

    Summary

    Official Symbol
    DEK1
    Official Full Name
    calpain-type cysteine protease family
    Primary source
    TAIR:AT1G55350
    Locus tag
    AT1G55350
    See related
    Araport:AT1G55350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATDEK1; DEFECTIVE KERNEL 1; EMB1275; EMB80; embryo defective 1275; EMBRYO DEFECTIVE 80; F7A10.23; F7A10_23
    Summary
    Similar to maize DEK1, a gene encoding a membrane protein of the calpain gene superfamily required for aleurone cell development in the endosperm of maize grains. A key component of the embryonic L1 cell-layer specification pathway. It localizes to membranes and undergoes intramolecular autolytic cleavage events that release the calpain domain into the cytoplasm.
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    Genomic context

    See DEK1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    32
    Sequence:
    Chromosome: 1; NC_003070.9 (20653740..20665110, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene RNA polymerase II transcription mediator Neighboring gene uncharacterized protein Neighboring gene arabinogalactan protein 21 Neighboring gene hypothetical protein (DUF1639) Neighboring gene tRNA-splicing ligase (DUF239) Neighboring gene uncharacterized protein Neighboring gene NDH-dependent cyclic electron flow 5

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    NM_001198309.1
    NM_001333706.1
    NM_104411.4
    NM_180635.1
    NM_180636.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium-dependent cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cysteine-type peptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy NAS
    Non-traceable Author Statement
    more info
     
    NOT involved_in endosperm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in plant epidermal cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of adaxial/abaxial pattern formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of endosperm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of leaf development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of meristem structural organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in self proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_positive_effect sepal giant cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sepal giant cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    calpain-type cysteine protease family
    NP_001185238.1
    • DEFECTIVE KERNEL 1 (DEK1); FUNCTIONS IN: cysteine-type endopeptidase activity, calcium-dependent cysteine-type endopeptidase activity; INVOLVED IN: cell fate specification, embryo development ending in seed dormancy; LOCATED IN: plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase C2, calpain, domain III (InterPro:IPR022683), Peptidase C2, calpain, large subunit, domain III (InterPro:IPR022682), Peptidase, cysteine peptidase active site (InterPro:IPR000169), Concanavalin A-like lectin/glucanase (InterPro:IPR008985), Peptidase C2, calpain, catalytic domain (InterPro:IPR001300), Peptidase C2, calpain family (InterPro:IPR022684).
    NP_001319240.1
    • DEFECTIVE KERNEL 1 (DEK1); FUNCTIONS IN: cysteine-type endopeptidase activity, calcium-dependent cysteine-type endopeptidase activity; INVOLVED IN: cell fate specification, embryo development ending in seed dormancy; LOCATED IN: plasma membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase C2, calpain, domain III (InterPro:IPR022683), Peptidase C2, calpain, large subunit, domain III (InterPro:IPR022682), Peptidase, cysteine peptidase active site (InterPro:IPR000169), Concanavalin A-like lectin/glucanase (InterPro:IPR008985), Peptidase C2, calpain, catalytic domain (InterPro:IPR001300), Peptidase C2, calpain family (InterPro:IPR022684); Has 3377 Blast hits to 2425 proteins in 256 species: Archae - 0; Bacteria - 87; Metazoa - 1580; Fungi - 264; Plants - 115; Viruses - 0; Other Eukaryotes - 1331 (source: NCBI BLink).
    NP_175932.2
    • DEFECTIVE KERNEL 1 (DEK1); FUNCTIONS IN: cysteine-type endopeptidase activity, calcium-dependent cysteine-type endopeptidase activity; INVOLVED IN: cell fate specification, embryo development ending in seed dormancy; LOCATED IN: plasma membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase C2, calpain, domain III (InterPro:IPR022683), Peptidase C2, calpain, large subunit, domain III (InterPro:IPR022682), Peptidase, cysteine peptidase active site (InterPro:IPR000169), Concanavalin A-like lectin/glucanase (InterPro:IPR008985), Peptidase C2, calpain, catalytic domain (InterPro:IPR001300), Peptidase C2, calpain family (InterPro:IPR022684); Has 3377 Blast hits to 2425 proteins in 256 species: Archae - 0; Bacteria - 87; Metazoa - 1580; Fungi - 264; Plants - 115; Viruses - 0; Other Eukaryotes - 1331 (source: NCBI BLink).
    NP_850966.1
    • DEFECTIVE KERNEL 1 (DEK1); FUNCTIONS IN: cysteine-type endopeptidase activity, calcium-dependent cysteine-type endopeptidase activity; INVOLVED IN: cell fate specification, embryo development ending in seed dormancy; LOCATED IN: plasma membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase C2, calpain, domain III (InterPro:IPR022683), Peptidase C2, calpain, large subunit, domain III (InterPro:IPR022682), Peptidase, cysteine peptidase active site (InterPro:IPR000169), Concanavalin A-like lectin/glucanase (InterPro:IPR008985), Peptidase C2, calpain, catalytic domain (InterPro:IPR001300), Peptidase C2, calpain family (InterPro:IPR022684); Has 3377 Blast hits to 2425 proteins in 256 species: Archae - 0; Bacteria - 87; Metazoa - 1580; Fungi - 264; Plants - 115; Viruses - 0; Other Eukaryotes - 1331 (source: NCBI BLink).
    NP_850967.1
    • DEFECTIVE KERNEL 1 (DEK1); FUNCTIONS IN: cysteine-type endopeptidase activity, calcium-dependent cysteine-type endopeptidase activity; INVOLVED IN: cell fate specification, embryo development ending in seed dormancy; LOCATED IN: plasma membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase C2, calpain, domain III (InterPro:IPR022683), Peptidase C2, calpain, large subunit, domain III (InterPro:IPR022682), Peptidase, cysteine peptidase active site (InterPro:IPR000169), Concanavalin A-like lectin/glucanase (InterPro:IPR008985), Peptidase C2, calpain, catalytic domain (InterPro:IPR001300), Peptidase C2, calpain family (InterPro:IPR022684); Has 3377 Blast hits to 2425 proteins in 256 species: Archae - 0; Bacteria - 87; Metazoa - 1580; Fungi - 264; Plants - 115; Viruses - 0; Other Eukaryotes - 1331 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      20653740..20665110 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001333707.1NP_001321273.1  calpain-type cysteine protease family [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8RVL2, Q8VXW6, Q949X8, Q9C8A6
      UniProtKB/TrEMBL
      A0A178WD40, A0A5S9WQ51, A0A654EJ68
      Conserved Domains (3) summary
      cd00044
      Location:16961995
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
      cd00214
      Location:20012151
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      pfam13868
      Location:12461333
      TPH; Trichohyalin-plectin-homology domain
    2. NM_104411.4NP_175932.2  calpain-type cysteine protease family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175932.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8RVL2, Q8VXW6, Q949X8, Q9C8A6
      UniProtKB/TrEMBL
      A0A178WD40, A0A5S9WQ51, A0A654EJ68
      Conserved Domains (3) summary
      cd00044
      Location:16961995
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
      cd00214
      Location:20012151
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      pfam13868
      Location:12461333
      TPH; Trichohyalin-plectin-homology domain
    3. NM_001333706.1NP_001319240.1  calpain-type cysteine protease family [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8RVL2, Q8VXW6, Q949X8, Q9C8A6
      UniProtKB/TrEMBL
      A0A178WD40, A0A5S9WQ51, A0A654EJ68
      Conserved Domains (3) summary
      cd00044
      Location:16961995
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
      cd00214
      Location:20012151
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      pfam13868
      Location:12461333
      TPH; Trichohyalin-plectin-homology domain
    4. NM_180635.1NP_850966.1  calpain-type cysteine protease family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850966.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8RVL2, Q8VXW6, Q949X8, Q9C8A6
      UniProtKB/TrEMBL
      A0A178WD40, A0A5S9WQ51, A0A654EJ68
      Conserved Domains (3) summary
      cd00044
      Location:16961995
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
      cd00214
      Location:20012151
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      pfam13868
      Location:12461333
      TPH; Trichohyalin-plectin-homology domain
    5. NM_180636.1NP_850967.1  calpain-type cysteine protease family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850967.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8RVL2, Q8VXW6, Q949X8, Q9C8A6
      UniProtKB/TrEMBL
      A0A178WD40, A0A5S9WQ51, A0A654EJ68
      Conserved Domains (3) summary
      cd00044
      Location:16961995
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
      cd00214
      Location:20012151
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      pfam13868
      Location:12461333
      TPH; Trichohyalin-plectin-homology domain
    6. NM_001198309.1NP_001185238.1  calpain-type cysteine protease family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185238.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WD40, A0A654EJ68, F4I0A4
      Conserved Domains (4) summary
      cd00214
      Location:20292179
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      pfam00648
      Location:17242023
      Peptidase_C2; Calpain family cysteine protease
      pfam03879
      Location:12691324
      Cgr1; Cgr1 family
      cl22861
      Location:14531613
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...