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    HUB2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841968, updated on 22-Aug-2024

    Summary

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    Official Symbol
    HUB2
    Primary source
    TAIR:AT1G55250
    Locus tag
    AT1G55250
    See related
    Araport:AT1G55250
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F7A10.17; F7A10_17; histone mono-ubiquitination 2
    Summary
    Encodes one of two orthologous E3 ubiquitin ligases in Arabidopsis that are involved in monoubiquitination of histone H2B.
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    20
    Sequence:
    Chromosome: 1; NC_003070.9 (20606953..20612649)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene proteinase inhibitor I4, serpin (DUF716) Neighboring gene proteinase inhibitor I4, serpin (DUF716) Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene DUF538 family protein, putative (Protein of unknown function, DUF538) Neighboring gene ncRNA Neighboring gene Galactose oxidase/kelch repeat superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The chromatin-modifying protein HUB2 is involved in the regulation of lignin composition in xylem vessels. Zhang B, et al. J Exp Bot, 2020 Sep 19. PMID 32479638, Free PMC Article
    2. An Arabidopsis E3 ligase HUB2 increases histone H2B monoubiquitination and enhances drought tolerance in transgenic cotton. Chen H, et al. Plant Biotechnol J, 2019 Mar. PMID 30117653, Free PMC Article
    3. Histone H2B monoubiquitination is involved in the regulation of cutin and wax composition in Arabidopsis thaliana. Ménard R, et al. Plant Cell Physiol, 2014 Feb. PMID 24319075
    4. The Arabidopsis thaliana homolog of yeast BRE1 has a function in cell cycle regulation during early leaf and root growth. Fleury D, et al. Plant Cell, 2007 Feb. PMID 17329565, Free PMC Article
    5. Monoubiquitination of histone 2B at the disease resistance gene locus regulates its expression and impacts immune responses in Arabidopsis. Zou B, et al. Plant Physiol, 2014 May. PMID 24664204, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ATX1 and HUB1/2 promote recruitment of the transcription elongation factor VIP2 to modulate the floral transition in Arabidopsis.
      Title: ATX1 and HUB1/2 promote recruitment of the transcription elongation factor VIP2 to modulate the floral transition in Arabidopsis.
    2. The chromatin-modifying protein HUB2 is involved in the regulation of lignin composition in xylem vessels.
      Title: The chromatin-modifying protein HUB2 is involved in the regulation of lignin composition in xylem vessels.
    3. increases histone H2B monoubiquitination and enhances drought tolerance in transgenic cotton
      Title: An Arabidopsis E3 ligase HUB2 increases histone H2B monoubiquitination and enhances drought tolerance in transgenic cotton.
    4. Two RING E3 ligases, HISTONE MONOUBIQUITINATION 1 and 2 (HUB1 and HUB2), play a role in the selective transcriptional activation of four cuticle biosynthesis genes in Arabidopsis thaliana.
      Title: Histone H2B monoubiquitination is involved in the regulation of cutin and wax composition in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001160956.1
    NM_001198304.1
    NM_001198305.2
    NM_104398.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables histone H2B deubiquitinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone ubiquitin ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within innate immune response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within seed dormancy process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vegetative to reproductive phase transition of meristem IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    histone mono-ubiquitination 2
    NP_001154428.1
    • histone mono-ubiquitination 2; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type, conserved site (InterPro:IPR017907), Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: histone mono-ubiquitination 1 (TAIR:AT2G44950.1); Has 53227 Blast hits to 28888 proteins in 1952 species: Archae - 744; Bacteria - 5895; Metazoa - 28581; Fungi - 4356; Plants - 2855; Viruses - 120; Other Eukaryotes - 10676 (source: NCBI BLink).
    NP_001185233.1
    • histone mono-ubiquitination 2 (HUB2); CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type, conserved site (InterPro:IPR017907), Zinc finger, RING-type (InterPro:IPR001841); BEST Arabidopsis thaliana protein match is: histone mono-ubiquitination 1 (TAIR:AT2G44950.1).
    NP_001185234.1
    • histone mono-ubiquitination 2 (HUB2); CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type, conserved site (InterPro:IPR017907), Zinc finger, RING-type (InterPro:IPR001841); BEST Arabidopsis thaliana protein match is: histone mono-ubiquitination 1 (TAIR:AT2G44950.1).
    NP_564680.4
    • histone mono-ubiquitination 2 (HUB2); CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type, conserved site (InterPro:IPR017907), Zinc finger, RING-type (InterPro:IPR001841); BEST Arabidopsis thaliana protein match is: histone mono-ubiquitination 1 (TAIR:AT2G44950.1); Has 74071 Blast hits to 42895 proteins in 2604 species: Archae - 973; Bacteria - 11117; Metazoa - 35835; Fungi - 6236; Plants - 4620; Viruses - 230; Other Eukaryotes - 15060 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      20606953..20612649
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001333696.1 → NP_001321104.1  histone mono-ubiquitination 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8APW2, A0A654EUD4, A0A7G2E4S3
      Conserved Domains (3) summary
      TIGR02168
      Location:464 → 804
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd16499
      Location:827 → 868
      RING-HC_BRE1_like; RING finger, HC subclass, found in yeast Bre1 and its homologs from eukaryotes
      pfam05557
      Location:196 → 715
      MAD; Mitotic checkpoint protein

    2. NM_001198304.1 → NP_001185233.1  histone mono-ubiquitination 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185233.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2E4S3, F4I079
      Conserved Domains (1) summary
      smart00184
      Location:833 → 885
      RING; Ring finger

    3. NM_104398.4 → NP_564680.4  histone mono-ubiquitination 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564680.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q058L1, Q8LDW7, Q9C895
      UniProtKB/TrEMBL
      A0A7G2E4S3
      Conserved Domains (1) summary
      smart00184
      Location:848 → 886
      RING; Ring finger

    4. NM_001198305.2 → NP_001185234.1  histone mono-ubiquitination 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185234.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WJX7, F4I080
      Conserved Domains (1) summary
      smart00184
      Location:331 → 383
      RING; Ring finger

    5. NM_001160956.1 → NP_001154428.1  histone mono-ubiquitination 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154428.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WHT6, A0A178WJX7
      Conserved Domains (1) summary
      smart00184
      Location:331 → 369
      RING; Ring finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C895.2

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