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    FTSH1 FTSH protease 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841447, updated on 7-Sep-2023

    Summary

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    Gene symbol
    FTSH1
    Gene description
    FTSH protease 1
    Primary source
    Araport:AT1G50250
    Locus tag
    AT1G50250
    See related
    TAIR:AT1G50250
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F14I3.14; F14I3_14; FTSH protease 1
    Summary
    encodes an FTSH protease that is localized to the chloroplast. Involved in the D1 repair cycle of Photosystem II. FtsH1 and FtsH5 are interchangeable in thylakoid membranes.
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    Genomic context

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    See FTSH1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (18614201..18617155, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene B3 domain protein Neighboring gene kinase family with ARM repeat domain-containing protein Neighboring gene N-terminal-transmembrane-C2 domain type 5.1 Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene Phototropic-responsive NPH3 family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The FtsH protease heterocomplex in Arabidopsis: dispensability of type-B protease activity for proper chloroplast development. Zhang D, et al. Plant Cell, 2010 Nov. PMID 21062893, Free PMC Article
    2. Quality control of photosystem II: FtsH hexamers are localized near photosystem II at grana for the swift repair of damage. Yoshioka M, et al. J Biol Chem, 2010 Dec 31. PMID 20921219, Free PMC Article
    3. Functional redundancy of AtFtsH metalloproteases in thylakoid membrane complexes. Yu F, et al. Plant Physiol, 2005 Aug. PMID 16040665, Free PMC Article
    4. Mutations in the Arabidopsis VAR2 locus cause leaf variegation due to the loss of a chloroplast FtsH protease. Chen M, et al. Plant J, 2000 May. PMID 10849347
    5. The E3 ligase AtCHIP ubiquitylates FtsH1, a component of the chloroplast FtsH protease, and affects protein degradation in chloroplasts. Shen G, et al. Plant J, 2007 Oct. PMID 17714429

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results elucidate protein activity and its amount as important factors for the function of FtsH heterocomplexes that are composed of multiple isoforms in the thylakoid membrane.
      Title: The FtsH protease heterocomplex in Arabidopsis: dispensability of type-B protease activity for proper chloroplast development.
    2. part of the FtsH hexamers are juxtapositioned to PSII complexes in the grana in darkness, carrying out immediate degradation of the photodamaged D1 protein under light stress
      Title: Quality control of photosystem II: FtsH hexamers are localized near photosystem II at grana for the swift repair of damage.
    3. The interaction of CHIP with FtsH1 in vitro, in normal and in CHIP-over-expressing plants is reported.
      Title: The E3 ligase AtCHIP ubiquitylates FtsH1, a component of the chloroplast FtsH protease, and affects protein degradation in chloroplasts.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_103909.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within PSII associated light-harvesting complex II catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within photosystem II repair TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast thylakoid HDA PubMed 
    located_in chloroplast thylakoid membrane HDA PubMed 
    located_in chloroplast thylakoid membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in thylakoid lumen HDA PubMed 

    General protein information

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    Preferred Names
    FTSH protease 1
    NP_564563.1
    • FTSH protease 1 (FTSH1); FUNCTIONS IN: metallopeptidase activity, protein binding, ATP-dependent peptidase activity, ATPase activity; INVOLVED IN: photosystem II repair, PSII associated light-harvesting complex II catabolic process; LOCATED IN: thylakoid lumen, chloroplast thylakoid membrane, chloroplast, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase M41, FtsH (InterPro:IPR005936), ATPase, AAA+ type, core (InterPro:IPR003593), ATPase, AAA-type, core (InterPro:IPR003959), ATPase, AAA-type, conserved site (InterPro:IPR003960), Peptidase M41 (InterPro:IPR000642); BEST Arabidopsis thaliana protein match is: FtsH extracellular protease family (TAIR:AT5G42270.1); Has 39789 Blast hits to 37355 proteins in 3308 species: Archae - 1512; Bacteria - 16133; Metazoa - 4957; Fungi - 3666; Plants - 3305; Viruses - 34; Other Eukaryotes - 10182 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      18614201..18617155 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_103909.4 → NP_564563.1  FTSH protease 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564563.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04172, Q39102, Q9SX43
      UniProtKB/TrEMBL
      A0A178W3Y5, A0A5S9WNH0
      Conserved Domains (1) summary
      TIGR01241
      Location:242 → 706
      FtsH_fam; ATP-dependent metalloprotease FtsH
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q39102.2

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