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    GLR3.4 glutamate receptor 3.4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839268, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GLR3.4
    Official Full Name
    glutamate receptor 3.4
    Primary source
    TAIR:AT1G05200
    Locus tag
    AT1G05200
    See related
    Araport:AT1G05200
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATGLR3.4; GLUR3; glutamate receptor 3.4; LIGAND-GATED CHANNEL-LIKE PROTEIN PRECURSOR; YUP8H12.19; YUP8H12_19
    Summary
    Encodes a putative glutamate receptor GLR3 with dual localization in plastid and plasma membrane.
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    Genomic context

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    See GLR3.4 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (1504941..1509152)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene NAD(P)-binding Rossmann-fold superfamily protein Neighboring gene Ribosomal protein L6 family Neighboring gene ncRNA Neighboring gene hexokinase-1 protein Neighboring gene ncRNA Neighboring gene Transmembrane protein 97, Putative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of the Arabidopsis thaliana glutamate receptor-like channel GLR3.4. Green MN, et al. Mol Cell, 2021 Aug 5. PMID 34161757, Free PMC Article
    2. Glutamate Receptor Homolog3.4 is Involved in Regulation of Seed Germination Under Salt Stress in Arabidopsis. Cheng Y, et al. Plant Cell Physiol, 2018 May 1. PMID 29432559
    3. Ca(2+) conduction by an amino acid-gated ion channel related to glutamate receptors. Vincill ED, et al. Plant Physiol, 2012 May. PMID 22447719, Free PMC Article
    4. Dual localization of plant glutamate receptor AtGLR3.4 to plastids and plasmamembrane. Teardo E, et al. Biochim Biophys Acta, 2011 Mar. PMID 21110940
    5. AtGLR3.4, a glutamate receptor channel-like gene is sensitive to touch and cold. Meyerhoff O, et al. Planta, 2005 Oct. PMID 15864638

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure of the Arabidopsis thaliana glutamate receptor-like channel GLR3.4.
      Title: Structure of the Arabidopsis thaliana glutamate receptor-like channel GLR3.4.
    2. AtGLR3.4-mediated Ca2+ influx may be involved in the regulation of seed germination under salt stress.
      Title: Glutamate Receptor Homolog3.4 is Involved in Regulation of Seed Germination Under Salt Stress in Arabidopsis.
    3. Data indicate that in roots, GLR3.4 and GLR3.2 were present primarily in the phloem, especially in the vicinity of the sieve plates, and GLR3.3 was expressed in most cells of the growing primary root but was not enriched in the phloem.
      Title: Interacting glutamate receptor-like proteins in Phloem regulate lateral root initiation in Arabidopsis.
    4. The effect of 6 amino acids on the glutamate receptors of A. thaliana, and the role of GLR3.3 and GLR3.4 in the channel mechanisms are reported.
      Title: Glutamate receptor subtypes evidenced by differences in desensitization and dependence on the GLR3.3 and GLR3.4 genes.
    5. AtGLR3.4 in particular and GLRs in general could play an important role in the Ca(2+) -based, fast transmission of environmental stress.
      Title: AtGLR3.4, a glutamate receptor channel-like gene is sensitive to touch and cold.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001035894.1
    NM_001331525.1
    NM_001331526.1
    NM_001331527.1
    NM_100398.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glutamate receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables intracellularly ligand-gated monoatomic ion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ligand-gated monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium-mediated signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in cellular response to abscisic acid stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to acetate IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to amino acid stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular calcium ion homeostasis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to light stimulus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutamate receptor 3.4
    NP_001030971.1
    • glutamate receptor 3.4 (GLR3.4); FUNCTIONS IN: protein binding, intracellular ligand-gated ion channel activity; INVOLVED IN: cellular calcium ion homeostasis, response to light stimulus; LOCATED IN: integral to membrane, membrane; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Extracellular solute-binding protein, family 3 (InterPro:IPR001638), Ionotropic glutamate receptor (InterPro:IPR001320), Glutamate receptor-related (InterPro:IPR015683), GPCR, family 3, gamma-aminobutyric acid receptor, type B (InterPro:IPR002455), Extracellular ligand-binding receptor (InterPro:IPR001828), Ionotropic glutamate-like receptor, plant (InterPro:IPR017103); BEST Arabidopsis thaliana protein match is: glutamate receptor 3.5 (TAIR:AT2G32390.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_172012.2
    • glutamate receptor 3.4 (GLR3.4); FUNCTIONS IN: protein binding, intracellular ligand-gated ion channel activity; INVOLVED IN: cellular calcium ion homeostasis, response to light stimulus; LOCATED IN: integral to membrane, membrane; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Extracellular solute-binding protein, family 3 (InterPro:IPR001638), Ionotropic glutamate receptor (InterPro:IPR001320), Extracellular ligand-binding receptor (InterPro:IPR001828), Glutamate receptor-related (InterPro:IPR015683), GPCR, family 3, gamma-aminobutyric acid receptor, type B (InterPro:IPR002455), Ionotropic glutamate-like receptor, plant (InterPro:IPR017103); BEST Arabidopsis thaliana protein match is: glutamate receptor 3.5 (TAIR:AT2G32390.2); Has 6705 Blast hits to 6546 proteins in 599 species: Archae - 47; Bacteria - 1309; Metazoa - 4441; Fungi - 0; Plants - 637; Viruses - 0; Other Eukaryotes - 271 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      1504941..1509152
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001331523.1 → NP_001320827.1  glutamate receptor 3.4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AP10, A0A5S9SP43
      Conserved Domains (2) summary
      cd19990
      Location:62 → 450
      PBP1_GABAb_receptor_plant; periplasmic ligand-binding domain of Arabidopsis thaliana glutamate receptors and its close homologs in other plants
      cl21456
      Location:492 → 807
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

    2. NM_001331524.1 → NP_001320829.1  glutamate receptor 3.4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WK93, A0A1P8AP36

    3. NM_001035894.1 → NP_001030971.1  glutamate receptor 3.4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030971.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23048, Q8GXJ4, Q8LGM9, Q9SWD9
      UniProtKB/TrEMBL
      A0A5S9SP43, A0A654EC03, Q53YX3
      Conserved Domains (3) summary
      cd19990
      Location:62 → 450
      PBP1_GABAb_receptor_plant; periplasmic ligand-binding domain of Arabidopsis thaliana glutamate receptors and its close homologs in other plants
      pfam00060
      Location:615 → 869
      Lig_chan; Ligand-gated ion channel
      cl21456
      Location:507 → 591
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

    4. NM_001331525.1 → NP_001320828.1  glutamate receptor 3.4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WKA8

    5. NM_100398.3 → NP_172012.2  glutamate receptor 3.4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172012.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23048, Q8GXJ4, Q8LGM9, Q9SWD9
      UniProtKB/TrEMBL
      A0A5S9SP43, A0A654EC03, Q53YX3
      Conserved Domains (3) summary
      cd19990
      Location:62 → 450
      PBP1_GABAb_receptor_plant; periplasmic ligand-binding domain of Arabidopsis thaliana glutamate receptors and its close homologs in other plants
      pfam00060
      Location:615 → 869
      Lig_chan; Ligand-gated ion channel
      cl21456
      Location:507 → 591
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

    6. NM_001331526.1 → NP_001320831.1  glutamate receptor 3.4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23048, Q8GXJ4, Q8LGM9, Q9SWD9
      UniProtKB/TrEMBL
      A0A5S9SP43, A0A654EC03, Q53YX3
      Conserved Domains (3) summary
      cd19990
      Location:62 → 450
      PBP1_GABAb_receptor_plant; periplasmic ligand-binding domain of Arabidopsis thaliana glutamate receptors and its close homologs in other plants
      pfam00060
      Location:615 → 869
      Lig_chan; Ligand-gated ion channel
      cl21456
      Location:507 → 591
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

    7. NM_001331527.1 → NP_001320830.1  glutamate receptor 3.4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AP10, A0A5S9SP43
      Conserved Domains (2) summary
      cd19990
      Location:62 → 450
      PBP1_GABAb_receptor_plant; periplasmic ligand-binding domain of Arabidopsis thaliana glutamate receptors and its close homologs in other plants
      cl21456
      Location:492 → 807
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GXJ4.2

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