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    LAS GRAS family transcription factor [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842007, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LAS
    Official Full Name
    GRAS family transcription factor
    Primary source
    TAIR:AT1G55580
    Locus tag
    AT1G55580
    See related
    Araport:AT1G55580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F20N2.1; Lateral Suppressor; SCARECROW-LIKE 18; SCL18
    Summary
    Encodes a member of the GRAS family of putative transcriptional regulators. It is involved in the initiation of axillary meristems during both the vegetative and reproductive growth phases and functions upstream of REV and AXR1 in the regulation of shoot branching.
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    Genomic context

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    See LAS in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    1
    Sequence:
    Chromosome: 1; NC_003070.9 (20763844..20765823)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene SKU5 similar 14 Neighboring gene SKU5 similar 12 Neighboring gene RNI-like superfamily protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Specific expression of LATERAL SUPPRESSOR is controlled by an evolutionarily conserved 3' enhancer. Raatz B, et al. Plant J, 2011 Nov. PMID 21722220
    2. Molecular analysis of the LATERAL SUPPRESSOR gene in Arabidopsis reveals a conserved control mechanism for axillary meristem formation. Greb T, et al. Genes Dev, 2003 May 1. PMID 12730136, Free PMC Article
    3. Arabidopsis REGULATOR OF AXILLARY MERISTEMS1 controls a leaf axil stem cell niche and modulates vegetative development. Keller T, et al. Plant Cell, 2006 Mar. PMID 16473968, Free PMC Article
    4. The bHLH protein ROX acts in concert with RAX1 and LAS to modulate axillary meristem formation in Arabidopsis. Yang F, et al. Plant J, 2012 Jul. PMID 22372440
    5. Interplay of miR164, CUP-SHAPED COTYLEDON genes and LATERAL SUPPRESSOR controls axillary meristem formation in Arabidopsis thaliana. Raman S, et al. Plant J, 2008 Jul. PMID 18346190

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ROX regulates axillary meristem formation redundantly with RAX1 and LAS.
      Title: The bHLH protein ROX acts in concert with RAX1 and LAS to modulate axillary meristem formation in Arabidopsis.
    2. The LAS/Ls 3' enhancer determines promoter function, irrespective of the 5' promoter. The pattern of LAS transcript accumulation is predominantly determined by the 3' enhancer.
      Title: Specific expression of LATERAL SUPPRESSOR is controlled by an evolutionarily conserved 3' enhancer.
    3. Studies on LAS transcript accumulation in mir164 triple mutants and cuc3-2 plants overexpressing miR164 suggest that regulation of axillary meristem formation by miR164 is mediated through CUC1 and CUC2, which in turn regulate LAS.
      Title: Interplay of miR164, CUP-SHAPED COTYLEDON genes and LATERAL SUPPRESSOR controls axillary meristem formation in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_104434.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within axillary shoot meristem initiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within secondary shoot formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    GRAS family transcription factor
    NP_175954.1
    • Lateral Suppressor (LAS); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity; INVOLVED IN: secondary shoot formation, regulation of transcription; LOCATED IN: chloroplast; EXPRESSED IN: 8 plant structures; EXPRESSED DURING: petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: Transcription factor GRAS (InterPro:IPR005202); BEST Arabidopsis thaliana protein match is: RGA-like 2 (TAIR:AT3G03450.1); Has 2438 Blast hits to 2402 proteins in 286 species: Archae - 0; Bacteria - 4; Metazoa - 0; Fungi - 4; Plants - 2430; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      20763844..20765823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104434.4 → NP_175954.1  GRAS family transcription factor [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175954.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A5YYE7, Q9ZWC5
      UniProtKB/TrEMBL
      A0A178WEV4, A0A5S9WML6, A0A7G2DY88
      Conserved Domains (1) summary
      pfam03514
      Location:41 → 445
      GRAS; GRAS domain family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZWC5.1

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