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    TIF3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856292, updated on 22-Aug-2024

    Summary

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    Official Symbol
    TIF3
    Primary source
    FungiDB:YPR163C
    Locus tag
    YPR163C
    See related
    SGD:S000006367; AllianceGenome:SGD:S000006367; VEuPathDB:YPR163C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RBL3; STM1
    Summary
    Enables RNA strand annealing activity; RNA strand-exchange activity; and ribosomal small subunit binding activity. Involved in cellular protein-containing complex assembly; positive regulation of ATPase activity; and regulation of RNA helicase activity. Located in cytoplasmic stress granule. Orthologous to human EIF4B (eukaryotic translation initiation factor 4B). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (868645..869955, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene cyclin-dependent serine/threonine protein kinase SGV1 Neighboring gene origin recognition complex subunit 4 Neighboring gene Mms1p Neighboring gene Rho family GTPase RHO1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The RNA recognition motif of yeast translation initiation factor Tif3/eIF4B is required but not sufficient for RNA strand-exchange and translational activity. Niederberger N, et al. RNA, 1998 Oct. PMID 9769100, Free PMC Article
    2. A Saccharomyces cerevisiae homologue of mammalian translation initiation factor 4B contributes to RNA helicase activity. Altmann M, et al. EMBO J, 1993 Oct. PMID 8404865, Free PMC Article
    3. The Saccharomyces cerevisiae translation initiation factor Tif3 and its mammalian homologue, eIF-4B, have RNA annealing activity. Altmann M, et al. EMBO J, 1995 Aug 1. PMID 7543843, Free PMC Article
    4. Yeast eIF4B binds to the head of the 40S ribosomal subunit and promotes mRNA recruitment through its N-terminal and internal repeat domains. Walker SE, et al. RNA, 2013 Feb. PMID 23236192, Free PMC Article
    5. A new yeast translation initiation factor suppresses a mutation in the eIF-4A RNA helicase. Coppolecchia R, et al. EMBO J, 1993 Oct. PMID 8404866, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results provide a comprehensive description of the critical sequence elements in yeIF4B that support eIF4F function in mRNA recruitment by the PIC.
      Title: Identification and characterization of functionally critical, conserved motifs in the internal repeats and N-terminal domain of yeast translation initiation factor 4B (yeIF4B).
    2. The 7-repeats and an N-terminal domain of yeIF4B (NTD) are the most critical domains, which mediate binding of yeIF4B to the head of the 40S ribosomal subunit via interaction with Rps20.
      Title: Yeast eIF4B binds to the head of the 40S ribosomal subunit and promotes mRNA recruitment through its N-terminal and internal repeat domains.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA strand annealing activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA strand-exchange activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding HDA PubMed 
    enables ribosomal small subunit binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in eukaryotic translation initiation factor 4F complex assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in eukaryotic translation initiation factor 4F complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in formation of translation preinitiation complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in translational initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic stress granule HDA PubMed 

    General protein information

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    Preferred Names
    Tif3p
    NP_015489.1
    • Translation initiation factor eIF-4B; RNA recognition motif containing single-stranded RNA binding protein that possesses RNA annealing and strand-exchange activities; stimulates the ATPase and unwinding activities of the RNA helicase eIF4A, in a synergistic manner with eIF4G; promotes assembly of the translation initiation factor complex eIF4F and the 48S preinitiation complex; interacts with Rps20p at the head of the 40S ribosomal subunit and alters the structure of the mRNA entry channel

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      868645..869955 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184260.1 → NP_015489.1  TPA: Tif3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015489.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4G4, P34167
      UniProtKB/TrEMBL
      A6ZX39, B3LKC4, C7GP46, C8ZJI9
      Conserved Domains (1) summary
      cd12514
      Location:102 → 179
      RRM4_RBM12_like; RNA recognition motif 4 (RRM4) found in RNA-binding protein RBM12, RBM12B and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34167.1

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