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    RRF1 Rrf1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856433, updated on 28-Oct-2024

    Summary

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    Official Symbol
    RRF1
    Official Full Name
    Rrf1p
    Primary source
    SGD:S000001080
    Locus tag
    YHR038W
    See related
    AllianceGenome:SGD:S000001080; FungiDB:YHR038W; VEuPathDB:YHR038W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FIL1; KIM4
    Summary
    Predicted to enable ribosomal large subunit binding activity and translation release factor activity. Involved in mitochondrial translation. Located in mitochondrion. Orthologous to human MRRF (mitochondrial ribosome recycling factor). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See RRF1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (184066..184758)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Brl1p Neighboring gene 1-pyrroline-5-carboxylate dehydrogenase Neighboring gene meiotic recombination directing protein Neighboring gene H(+)-transporting V1 sector ATPase subunit G

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Temperature-sensitive mutation in yeast mitochondrial ribosome recycling factor (RRF). Teyssier E, et al. Nucleic Acids Res, 2003 Jul 15. PMID 12853640, Free PMC Article
    2. A regulatory factor, Fil1p, involved in derepression of the isocitrate lyase gene in Saccharomyces cerevisiae--a possible mitochondrial protein necessary for protein synthesis in mitochondria. Kanai T, et al. Eur J Biochem, 1998 Aug 15. PMID 9746366
    3. New protein functions in yeast chromosome VIII. Ouzounis C, et al. Protein Sci, 1995 Nov. PMID 8563640, Free PMC Article
    4. Ribosome recycling defects modify the balance between the synthesis and assembly of specific subunits of the oxidative phosphorylation complexes in yeast mitochondria. Ostojić J, et al. Nucleic Acids Res, 2016 Jul 8. PMID 27257059, Free PMC Article
    5. Chemicals or mutations that target mitochondrial translation can rescue the respiratory deficiency of yeast bcs1 mutants. Panozzo C, et al. Biochim Biophys Acta Mol Cell Res, 2017 Dec. PMID 28888990

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We found that the absence of non-essential translation factors Rrf1 or Mif3, which act at the recycling/initiation steps, also compensates for the respiratory deficiency of yeast bcs1 mutations
      Title: Chemicals or mutations that target mitochondrial translation can rescue the respiratory deficiency of yeast bcs1 mutants.
    2. It has been proposed that Rrf1 takes part in the coordination between translation and oxidative phosphorylation assembly in yeast mitochondria.
      Title: Ribosome recycling defects modify the balance between the synthesis and assembly of specific subunits of the oxidative phosphorylation complexes in yeast mitochondria.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ribosomal large subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation release factor activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational termination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rrf1p
    NP_011903.1
    • Mitochondrial ribosome recycling factor; essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      184066..184758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179168.1 → NP_011903.1  TPA: Rrf1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011903.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKY5, P38771
      UniProtKB/TrEMBL
      A6ZSU4, B3LSF8, G2WFB0, N1P1K1
      Conserved Domains (1) summary
      COG0233
      Location:45 → 230
      Frr; Ribosome recycling factor [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38771.1

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