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    PWP2 snoRNA-binding rRNA-processing protein PWP2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850422, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PWP2
    Official Full Name
    snoRNA-binding rRNA-processing protein PWP2
    Primary source
    SGD:S000000653
    Locus tag
    YCR057C
    See related
    AllianceGenome:SGD:S000000653; FungiDB:YCR057C; VEuPathDB:YCR057C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    UTP1; YCR055C; YCR058C
    Summary
    Enables mRNA binding activity. Involved in establishment of cell polarity; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and septum digestion after cytokinesis. Located in cytoplasm and nucleolus. Part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. Orthologous to human PWP2 (PWP2 small subunit processome component). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See PWP2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (220457..223228, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene threonine synthase THR4 Neighboring gene Ctr86p Neighboring gene Yih1p Neighboring gene Tah1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PWP2, a member of the WD-repeat family of proteins, is an essential Saccharomyces cerevisiae gene involved in cell separation. Shafaatian R, et al. Mol Gen Genet, 1996 Aug 27. PMID 8804409, Free PMC Article
    2. Co-variation of STI1 and WDR36/UTP21 alters cell proliferation in a glaucoma model. Footz T, et al. Mol Vis, 2011. PMID 21850170, Free PMC Article
    3. Ribosome biogenesis is sensed at the Start cell cycle checkpoint. Bernstein KA, et al. Mol Biol Cell, 2007 Mar. PMID 17192414, Free PMC Article
    4. Integrative structural analysis of the UTPB complex, an early assembly factor for eukaryotic small ribosomal subunits. Zhang C, et al. Nucleic Acids Res, 2016 Sep 6. PMID 27330138, Free PMC Article
    5. Mrd1p binds to pre-rRNA early during transcription independent of U3 snoRNA and is required for compaction of the pre-rRNA into small subunit processomes. Segerstolpe A, et al. Nucleic Acids Res, 2008 Aug. PMID 18586827, Free PMC Article

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pwp2 mediates UTP-B assembly via two structurally independent domains.
      Title: Pwp2 mediates UTP-B assembly via two structurally independent domains.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mRNA binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal small subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in septum digestion after cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of 90S preribosome HDA PubMed 
    part_of 90S preribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Pwp2p-containing subcomplex of 90S preribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Pwp2p-containing subcomplex of 90S preribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    snoRNA-binding rRNA-processing protein PWP2
    NP_009984.1
    • Conserved 90S pre-ribosomal component; essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      220457..223228 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178769.1 → NP_009984.1  TPA: snoRNA-binding rRNA-processing protein PWP2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009984.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR63, P25633, P25635, P25636
      UniProtKB/TrEMBL
      A6ZTN4, C8Z4E7
      Conserved Domains (4) summary
      COG2319
      Location:330 → 718
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:139 → 501
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:265 → 300
      7WD40; WD40 repeat [structural motif]
      pfam04003
      Location:746 → 851
      Utp12; Dip2/Utp12 Family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25635.2

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