KRT15 keratin 15 [Homo sapiens (human)] - Gene

Summary

Official Symbol: KRT15provided by HGNC
Official Full Name: keratin 15provided by HGNC
Primary source: HGNC:HGNC:6421
See related: Ensembl:ENSG00000171346 MIM:148030; AllianceGenome:HGNC:6421
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: K15; CK15; K1CO
Summary: The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2. [provided by RefSeq, Jul 2008]
Expression: Biased expression in skin (RPKM 317.3), esophagus (RPKM 283.6) and 1 other tissue See more
Orthologs: mouse all
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Genomic context

Location:: 17q21.2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (41513745..41518890, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (42369289..42379059, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (39669997..39675142, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of keratin 15 is required for varicella-zoster virus replication in keratinocytes and is attenuated in the live attenuated vOka vaccine strain.
Title: Upregulation of keratin 15 is required for varicella-zoster virus replication in keratinocytes and is attenuated in the live attenuated vOka vaccine strain.
Tumor keratin 15 expression links with less extent of invasion and better prognosis in papillary thyroid cancer patients receiving tumor resection.
Title: Tumor keratin 15 expression links with less extent of invasion and better prognosis in papillary thyroid cancer patients receiving tumor resection.
Upregulated keratin 15 links to the occurrence of lymphovascular invasion, stromal cervical invasion as well as unfavorable survival profile in endometrial cancer patients.
Title: Upregulated keratin 15 links to the occurrence of lymphovascular invasion, stromal cervical invasion as well as unfavorable survival profile in endometrial cancer patients.
KRT15 promotes colorectal cancer cell migration and invasion through beta-catenin/MMP-7 signaling pathway.
Title: KRT15 promotes colorectal cancer cell migration and invasion through β-catenin/MMP-7 signaling pathway.
KRT 15 as a prognostic biomarker is highly expressed in esophageal carcinoma.
Title: KRT 15 as a prognostic biomarker is highly expressed in esophageal carcinoma.
Potential regulatory SNPs in the ATXN7L3B and KRT15 genes are associated with gender-specific colorectal cancer risk.
Title: Potential regulatory SNPs in the ATXN7L3B and KRT15 genes are associated with gender-specific colorectal cancer risk.
KRT15 overexpression predicts poor prognosis in colorectal cancer.
Title: KRT15 overexpression predicts poor prognosis in colorectal cancer.
BerEP4 differentiates between microcystic adnexal carcinoma and morpheaform basal cell carcinoma.
Title: The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers.
The protein CK15 can be used for the differential diagnosis between high-grade dysplasia and oral epithelial malignancy at the stage of carcinoma in situ and squamous cell carcinoma.
Title: Immunohistochemical study of Ki-67, PHH3, and CK15 protein expression in oral epithelial malignancy.
Underexpression of CK15 is associated with Esophageal Squamous Cell Carcinomas.
Title: Cytokeratin 15 is an Effective Indicator for Progression and Malignancy of Esophageal Squamous Cell Carcinomas.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-12347 (e-PCR)
- UniSTS:57368

Krt15 (e-PCR), detects polymorphism
- UniSTS:474754

D11S3114 (e-PCR)
- UniSTS:152207

SHGC-79605 (e-PCR)
- UniSTS:104592

RH17477 (e-PCR)
- UniSTS:48796

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of cytoskeleton	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in epidermis development	TAS Traceable Author Statement more info	PubMed
involved_in epithelial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: keratin, type I cytoskeletal 15

Names: CK-15; cytokeratin 15; keratin 15, type I; keratin-15, basic; keratin-15, beta; type I cytoskeletal 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012284.2 RefSeqGene

Range

5000..10145

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_002275.4 → NP_002266.3 keratin, type I cytoskeletal 15

Status: REVIEWED

Source sequence(s)

AC019349

Consensus CDS

CCDS11398.1

UniProtKB/Swiss-Prot

B3KQY1, B3KRA2, E0CX14, P19012, Q53XV8, Q9BUG4

UniProtKB/TrEMBL

B3KVF5

Related

ENSP00000254043.3, ENST00000254043.8

Conserved Domains (1) summary

pfam00038
Location:104 → 416

Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

41513745..41518890 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011524784.4 → XP_011523086.1 keratin, type I cytoskeletal 15 isoform X1

UniProtKB/TrEMBL

B3KVF5

Conserved Domains (1) summary

pfam00038
Location:104 → 423

Filament; Intermediate filament protein
XM_017024614.3 → XP_016880103.1 keratin, type I cytoskeletal 15 isoform X2

UniProtKB/TrEMBL

B3KVF5

Conserved Domains (1) summary

pfam00038
Location:104 → 423

Filament; Intermediate filament protein