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    Reep3 receptor accessory protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 28193, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Reep3provided by MGI
    Official Full Name
    receptor accessory protein 3provided by MGI
    Primary source
    MGI:MGI:88930
    See related
    Ensembl:ENSMUSG00000019873 AllianceGenome:MGI:88930
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D10Ucla1
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in endoplasmic reticulum tubular network organization and mitotic nuclear membrane reassembly. Predicted to be located in microtubule. Predicted to be active in cytoplasmic microtubule; endoplasmic reticulum membrane; and endoplasmic reticulum tubular network. Is expressed in several structures, including heart valve; limb segment; trigeminal ganglion; and ventricular layer. Orthologous to human REEP3 (receptor accessory protein 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 16.4), subcutaneous fat pad adult (RPKM 9.6) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Reep3 in Genome Data Viewer
    Location:
    10 B5.1; 10 34.83 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (66844968..66932767, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (67009189..67096988, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1110002J07 gene Neighboring gene STARR-seq mESC enhancer starr_26972 Neighboring gene STARR-seq mESC enhancer starr_26973 Neighboring gene STARR-positive B cell enhancer ABC_E5143 Neighboring gene STARR-positive B cell enhancer ABC_E6865 Neighboring gene STARR-seq mESC enhancer starr_26976 Neighboring gene predicted gene, 53603 Neighboring gene STARR-seq mESC enhancer starr_26978 Neighboring gene VISTA enhancer mm1692 Neighboring gene STARR-seq mESC enhancer starr_26980 Neighboring gene STARR-seq mESC enhancer starr_26981 Neighboring gene predicted gene, 31763 Neighboring gene STARR-positive B cell enhancer mm9_chr10:66531454-66531755 Neighboring gene STARR-positive B cell enhancer ABC_E8340 Neighboring gene STARR-seq mESC enhancer starr_26991 Neighboring gene STARR-seq mESC enhancer starr_26992 Neighboring gene jumonji domain containing 1C Neighboring gene STARR-positive B cell enhancer ABC_E10618 Neighboring gene predicted gene, 26359 Neighboring gene STARR-seq mESC enhancer starr_26997 Neighboring gene nuclear receptor binding factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The expression of the evolutionarily conserved GATA/GACA repeats in mouse tissues. Schäfer R, et al. Chromosoma, 1986. PMID 3755389
    2. In silico identification of new candidate genes for hereditary congenital facial paresis. Tomás-Roca L, et al. Int J Dev Neurosci, 2011 Jun. PMID 21345367
    3. RTP family members induce functional expression of mammalian odorant receptors. Saito H, et al. Cell, 2004 Nov 24. PMID 15550249
    4. Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models. Kurogi S, et al. Sci Rep, 2017 Jan 20. PMID 28106071, Free PMC Article
    5. Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Warden CH, et al. Genomics, 1993 Nov. PMID 8288233

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum tubular network organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic nuclear membrane reassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic nuclear membrane reassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nuclear envelope organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear envelope organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum tubular network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    receptor expression-enhancing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204915.2 → NP_001191844.1  receptor expression-enhancing protein 3 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC153382, AC156272
      Consensus CDS
      CCDS88015.1
      UniProtKB/TrEMBL
      A0A1W2P8A8
      Related
      ENSMUSP00000151994.2, ENSMUST00000217841.2
      Conserved Domains (1) summary
      pfam03134
      Location:7 → 94
      TB2_DP1_HVA22; TB2/DP1, HVA22 family

    2. NM_001428928.1 → NP_001415857.1  receptor expression-enhancing protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC153382, AC156272

    3. NM_001428929.1 → NP_001415858.1  receptor expression-enhancing protein 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC153382, AC156272

    4. NM_178606.6 → NP_848721.1  receptor expression-enhancing protein 3 isoform 2

      See identical proteins and their annotated locations for NP_848721.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC153382, AC156272
      Consensus CDS
      CCDS35926.1
      UniProtKB/Swiss-Prot
      Q99KK1, Q9CZM8, Q9D8G3
      Related
      ENSMUSP00000020023.8, ENSMUST00000020023.9
      Conserved Domains (1) summary
      pfam03134
      Location:7 → 94
      TB2_DP1_HVA22; TB2/DP1, HVA22 family

    RNA

    1. NR_190541.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153382, AC156272

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      66844968..66932767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513726.4 → XP_006513789.1  receptor expression-enhancing protein 3 isoform X1

      Conserved Domains (1) summary
      pfam03134
      Location:4 → 80
      TB2_DP1_HVA22; TB2/DP1, HVA22 family

    2. XM_006513727.2 → XP_006513790.1  receptor expression-enhancing protein 3 isoform X2

      Conserved Domains (1) summary
      pfam03134
      Location:19 → 95
      TB2_DP1_HVA22; TB2/DP1, HVA22 family

    3. XM_006513728.2 → XP_006513791.1  receptor expression-enhancing protein 3 isoform X3

      See identical proteins and their annotated locations for XP_006513791.1

      Conserved Domains (1) summary
      pfam03134
      Location:19 → 95
      TB2_DP1_HVA22; TB2/DP1, HVA22 family

    4. XM_036155799.1 → XP_036011692.1  receptor expression-enhancing protein 3 isoform X3

      Conserved Domains (1) summary
      pfam03134
      Location:19 → 95
      TB2_DP1_HVA22; TB2/DP1, HVA22 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99KK1.1 GenPept UniProtKB/Swiss-Prot:Q99KK1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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