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    NUTM2D NUT family member 2D [ Homo sapiens (human) ]

    Gene ID: 728130, updated on 17-Sep-2024

    Summary

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    Official Symbol
    NUTM2Dprovided by HGNC
    Official Full Name
    NUT family member 2Dprovided by HGNC
    Primary source
    HGNC:HGNC:23447
    See related
    Ensembl:ENSG00000214562 AllianceGenome:HGNC:23447
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAM22D
    Expression
    Ubiquitous expression in testis (RPKM 1.6), brain (RPKM 1.5) and 25 other tissues See more
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    Genomic context

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    See NUTM2D in Genome Data Viewer
    Location:
    10q23.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (87357744..87370695)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (88241352..88254302)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (89117501..89130452)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:88987203-88987977 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:88988752-88989526 Neighboring gene NUT family member 2A Neighboring gene NUTM2A antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:89102067-89102674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2581 Neighboring gene long intergenic non-protein coding RNA 863 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:89114408-89114914 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:89114915-89115421 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:89119641-89120142 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:89142841-89143342 Neighboring gene nuclear pore associated protein 1 pseudogene 3 Neighboring gene cathepsin L pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC. Zeng H, et al. Elife, 2019 Nov 19. PMID 31741433, Free PMC Article
    2. The DNA sequence and comparative analysis of human chromosome 10. Deloukas P, et al. Nature, 2004 May 27. PMID 15164054
    3. Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism. Antoniali G, et al. Nat Commun, 2017 Oct 6. PMID 28986522, Free PMC Article
    4. High-throughput analyses of hnRNP H1 dissects its multi-functional aspect. Uren PJ, et al. RNA Biol, 2016. PMID 26760575, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • KIAA2020

    General protein information

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    Preferred Names
    NUT family member 2D
    Names
    NUT family member 2A pseudogene
    family with sequence similarity 22, member D
    protein FAM22D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009610.2 → NP_001009610.1  NUT family member 2D isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL645612
      UniProtKB/TrEMBL
      A0A075B6P9, A0A0A0MRQ8
      Related
      ENSP00000396080.1, ENST00000412718.3
      Conserved Domains (1) summary
      pfam12881
      Location:64 → 545
      NUT; NUT protein

    2. NM_001382304.1 → NP_001369233.1  NUT family member 2D isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL645612
      Consensus CDS
      CCDS91292.1
      UniProtKB/Swiss-Prot
      A6NGV9, Q5VT03
      Related
      ENSP00000371116.1, ENST00000381697.7
      Conserved Domains (1) summary
      pfam12881
      Location:64 → 803
      NUT; NUT protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      87357744..87370695
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      88241352..88254302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5VT03.2 GenPept UniProtKB/Swiss-Prot:Q5VT03

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials