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    Fndc5 fibronectin type III domain containing 5 [ Mus musculus (house mouse) ]

    Gene ID: 384061, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Fndc5provided by MGI
    Official Full Name
    fibronectin type III domain containing 5provided by MGI
    Primary source
    MGI:MGI:1917614
    See related
    Ensembl:ENSMUSG00000001334 AllianceGenome:MGI:1917614
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PeP; Pxp; 1500001L03Rik
    Summary
    This gene encodes a type I transmembrane protein containing fibronectin type III repeat. The encoded transmembrane protein undergoes proteolytic processing to generate a soluble hormone named irisin that is secreted into the bloodstream. The expression of this gene followed by the secretion of irisin from skeletal muscle is induced by exercise. The ectopic expression of the encoded protein in mice causes an elevation of irisin in blood and improves metabolic health. [provided by RefSeq, Jul 2016]
    Expression
    Biased expression in heart adult (RPKM 86.3), cerebellum adult (RPKM 47.9) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fndc5 in Genome Data Viewer
    Location:
    4 D2.2; 4 62.93 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129030672..129038386)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129136870..129144593)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10260 Neighboring gene STARR-positive B cell enhancer ABC_E3516 Neighboring gene ring finger protein 19B Neighboring gene transmembrane protein 54 Neighboring gene hippocalcin Neighboring gene STARR-positive B cell enhancer ABC_E4669 Neighboring gene S100P binding protein Neighboring gene STARR-positive B cell enhancer ABC_E3517 Neighboring gene STARR-seq mESC enhancer starr_11478 Neighboring gene tyrosyl-tRNA synthetase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Involvement of the p62/Nrf2/HO-1 pathway in the browning effect of irisin in 3T3-L1 adipocytes. Tsai YC, et al. Mol Cell Endocrinol, 2020 Aug 20. PMID 32540261
    2. FNDC5 Alleviates Hepatosteatosis by Restoring AMPK/mTOR-Mediated Autophagy, Fatty Acid Oxidation, and Lipogenesis in Mice. Liu TY, et al. Diabetes, 2016 Nov. PMID 27504012
    3. The immunomodulatory role of irisin on osteogenesis via AMPK-mediated macrophage polarization. Ye W, et al. Int J Biol Macromol, 2020 Mar 1. PMID 31843619
    4. Investigation of the expression of irisin and some cachectic factors in mice with experimentally induced gastric cancer. Us Altay D, et al. QJM, 2016 Dec. PMID 27256459
    5. Recombinant Irisin Prevents the Reduction of Osteoblast Differentiation Induced by Stimulated Microgravity through Increasing β-Catenin Expression. Chen Z, et al. Int J Mol Sci, 2020 Feb 13. PMID 32070052, Free PMC Article

    See all (142) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Effect of Hypoxia on Irisin Expression in HL-1 Cardiomyocytes.
      Title: The Effect of Hypoxia on Irisin Expression in HL-1 Cardiomyocytes.
    2. FNDC5 prevents oxidative stress and neuronal apoptosis after traumatic brain injury through SIRT3-dependent regulation of mitochondrial quality control.
      Title: FNDC5 prevents oxidative stress and neuronal apoptosis after traumatic brain injury through SIRT3-dependent regulation of mitochondrial quality control.
    3. Deletion of FNDC5/irisin modifies murine osteocyte function in a sex-specific manner.
      Title: Deletion of FNDC5/irisin modifies murine osteocyte function in a sex-specific manner.
    4. FNDC5/irisin ameliorates bone loss of type 1 diabetes by suppressing endoplasmic reticulum stress-mediated ferroptosis.
      Title: FNDC5/irisin ameliorates bone loss of type 1 diabetes by suppressing endoplasmic reticulum stress‑mediated ferroptosis.
    5. Exercise enhances placental labyrinth trophoblast development by activation of PGC-1alpha and FNDC5/irisindagger.
      Title: Exercise enhances placental labyrinth trophoblast development by activation of PGC-1α and FNDC5/irisin†.
    6. The integrated analysis and underlying mechanisms of FNDC5 on diabetic induced cognitive deficits.
      Title: The integrated analysis and underlying mechanisms of FNDC5 on diabetic induced cognitive deficits.
    7. Explore novel molecular mechanisms of FNDC5 in ischemia-reperfusion (I/R) injury by analyzing transcriptome changes in mouse model of skeletal muscle I/R injury with FNDC5 knockout.
      Title: Explore novel molecular mechanisms of FNDC5 in ischemia-reperfusion (I/R) injury by analyzing transcriptome changes in mouse model of skeletal muscle I/R injury with FNDC5 knockout.
    8. Fndc5/irisin deficiency leads to dysbiosis of gut microbiota contributing to the depressive-like behaviors in mice.
      Title: Fndc5/irisin deficiency leads to dysbiosis of gut microbiota contributing to the depressive-like behaviors in mice.
    9. FNDC5 Attenuates Atherosclerotic Plaque Formation and Regulates PPARalpha/HO-1 in ApoE-/- Mice.
      Title: FNDC5 Attenuates Atherosclerotic Plaque Formation and Regulates PPARα/HO-1 in ApoE-/- Mice.
    10. Irisin drives macrophage anti-inflammatory differentiation via JAK2-STAT6-dependent activation of PPARgamma and Nrf2 signaling.
      Title: Irisin drives macrophage anti-inflammatory differentiation via JAK2-STAT6-dependent activation of PPARγ and Nrf2 signaling.
    Submit: New GeneRIF Correction See all GeneRIFs (116)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC129464, MGC129465

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of brown fat cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of brown fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to muscle activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fibronectin type III domain-containing protein 5
    Names
    fibronectin type III repeat-containing protein 2
    peroxisomal protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027402.4 → NP_081678.1  fibronectin type III domain-containing protein 5 preproprotein

      See identical proteins and their annotated locations for NP_081678.1

      Status: REVIEWED

      Source sequence(s)
      AA003587, AI836596, AK005096, AL606977, BE861837, BG088140, BY265316, CX207206
      Consensus CDS
      CCDS18683.1
      UniProtKB/Swiss-Prot
      A0AA74KUW2, Q8K4Z2, Q9DB97
      Related
      ENSMUSP00000099660.4, ENSMUST00000102600.4
      Conserved Domains (2) summary
      cd00063
      Location:31 → 121
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam16066
      Location:148 → 181
      DUF4808; Domain of unknown function (DUF4808)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      129030672..129038386
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503212.5 → XP_006503275.1  fibronectin type III domain-containing protein 5 isoform X1

      See identical proteins and their annotated locations for XP_006503275.1

      Conserved Domains (1) summary
      cd00063
      Location:62 → 152
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K4Z2.1 GenPept UniProtKB/Swiss-Prot:Q8K4Z2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
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