U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ATS1 Ats1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851213, updated on 17-May-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    ATS1
    Gene description
    Ats1p
    Primary source
    FungiDB:YAL020C
    Locus tag
    YAL020C
    See related
    SGD:S000000018; AllianceGenome:SGD:S000000018; VEuPathDB:YAL020C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DPH8; FUN28; KTI13
    Summary
    Involved in tRNA wobble uridine modification. Located in cytoplasm. Orthologous to human SERGEF (secretion regulating guanine nucleotide exchange factor). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ATS1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (113614..114615, complement)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene nucleoside transmembrane transporter FUN26 Neighboring gene CCR4-NOT core exoribonuclease subunit CCR4 Neighboring gene DNA-dependent ATPase FUN30 Neighboring gene Lds1p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Structure of the Elongator cofactor complex Kti11/Kti13 provides insight into the role of Kti13 in Elongator-dependent tRNA modification. Kolaj-Robin O, et al. FEBS J, 2015 Mar. PMID 25604895
    2. Gene set coregulated by the Saccharomyces cerevisiae nonsense-mediated mRNA decay pathway. Taylor R, et al. Eukaryot Cell, 2005 Dec. PMID 16339724, Free PMC Article
    3. Structure of the Kti11/Kti13 heterodimer and its double role in modifications of tRNA and eukaryotic elongation factor 2. Glatt S, et al. Structure, 2015 Jan 6. PMID 25543256
    4. Saccharomyces cerevisiae Ats1p interacts with Nap1p, a cytoplasmic protein that controls bud morphogenesis. Shields CM, et al. Curr Genet, 2003 Dec. PMID 13680156
    5. KTI11 and KTI13, Saccharomyces cerevisiae genes controlling sensitivity to G1 arrest induced by Kluyveromyces lactis zymocin. Fichtner L, et al. Mol Microbiol, 2002 May. PMID 11994165

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Insight into the molecular mechanisms that allow the Kti11/Kti13 heterodimer to coregulate two consecutive steps in ribosomal protein synthesis.
      Title: Structure of the Kti11/Kti13 heterodimer and its double role in modifications of tRNA and eukaryotic elongation factor 2.
    2. Kti11 forms a stable 1 : 1 complex with Kti13.In the complex, Kti13 orients Kti11 and restricts access to its electron-carrying iron atom, constraining the electron transfer capacity of Kti11.
      Title: Structure of the Elongator cofactor complex Kti11/Kti13 provides insight into the role of Kti13 in Elongator-dependent tRNA modification.
    3. Kti13 and Kti11 support Elongator functions and they both share Elongator-independent roles that are important for cell viability.
      Title: Yeast alpha-tubulin suppressor Ats1/Kti13 relates to the Elongator complex and interacts with Elongator partner protein Kti11.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein histidyl modification to diphthamide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble uridine modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Ats1p
    NP_009382.2
    • Protein required for modification of wobble nucleosides in tRNA; acts with Elongator complex, Kti11p, and Kti12p; has a potential role in regulatory interactions between microtubules and the cell cycle; forms a stable heterodimer with Kti11p

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      113614..114615 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178165.2 → NP_009382.2  TPA: Ats1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009382.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPJ8, P31386
      UniProtKB/TrEMBL
      A0A8H4F9J2, A7A0E8, B3LUV4, C7GPL5, C8Z3K7, G2W8L2, N1P7K0
      Conserved Domains (1) summary
      COG5184
      Location:1 → 333
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P31386.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools