NTH2 alpha,alpha-trehalase NTH2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: NTH2
Official Full Name: alpha,alpha-trehalase NTH2
Primary source: SGD:S000000205
Locus tag: YBR001C
See related: AllianceGenome:SGD:S000000205; FungiDB:YBR001C; VEuPathDB:YBR001C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables alpha,alpha-trehalase activity. Involved in trehalose catabolic process. Located in mitochondrion. Orthologous to human TREH (trehalase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See NTH2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (238941..241283, complement)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The behaviour of trehalase mutant strains demonstrates the participation of trehalases Nth1p, Nth2p and Ath1p in the mobilization of intracellular trehalose during growth recovery after saline stress.
Title: The three trehalases Nth1p, Nth2p and Ath1p participate in the mobilization of intracellular trehalose required for recovery from saline stress in Saccharomyces cerevisiae.
In this work, we showed that NTH2, a paralog of NTH1, encodes a functional trehalase that is implicated in trehalose mobilization.
Title: New insights into trehalose metabolism by Saccharomyces cerevisiae: NTH2 encodes a functional cytosolic trehalase, and deletion of TPS1 reveals Ath1p-dependent trehalose mobilization.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables alpha,alpha-trehalase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha,alpha-trehalase activity	IEA Inferred from Electronic Annotation more info
enables alpha,alpha-trehalase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
enables trehalase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in trehalose catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in trehalose catabolic process	IEA Inferred from Electronic Annotation more info
involved_in trehalose catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: alpha,alpha-trehalase NTH2

NP_009555.1

EC 3.2.1.28

Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

238941..241283 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178349.1 → NP_009555.1 TPA: alpha,alpha-trehalase NTH2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009555.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQ02, P35172

UniProtKB/TrEMBL

G2W909

Conserved Domains (1) summary

COG1626
Location:117 → 755

TreA; Neutral trehalase [Carbohydrate transport and metabolism]