Aup1 AUP1, lipid droplet regulating VLDL assembly factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aup1provided by RGD
Official Full Name: AUP1, lipid droplet regulating VLDL assembly factorprovided by RGD
Primary source: RGD:1591777
See related: EnsemblRapid:ENSRNOG00000007842 AllianceGenome:RGD:1591777
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable enzyme binding activity; ubiquitin binding activity; and ubiquitin-protein transferase activator activity. Predicted to be involved in several processes, including ERAD pathway; lipid droplet formation; and lipophagy. Predicted to be located in autophagosome; endoplasmic reticulum; and lipid droplet. Predicted to be part of Hrd1p ubiquitin ligase ERAD-L complex. Predicted to be active in membrane. Predicted to be integral component of endoplasmic reticulum membrane. Orthologous to human AUP1 (AUP1 lipid droplet regulating VLDL assembly factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 260.8), Kidney (RPKM 258.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (117118035..117121063)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (115560274..115563346)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (113887030..113890103)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-19737 (e-PCR)
- UniSTS:61045

RH124966 (e-PCR)
- UniSTS:161788

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin conjugating enzyme binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERAD pathway	IEA Inferred from Electronic Annotation more info
involved_in ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in ERAD pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid droplet formation	IEA Inferred from Electronic Annotation more info
involved_in lipid droplet formation	ISO Inferred from Sequence Orthology more info
involved_in lipid droplet formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid droplet organization	ISO Inferred from Sequence Orthology more info
involved_in lipid droplet organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipophagy	IEA Inferred from Electronic Annotation more info
involved_in lipophagy	ISO Inferred from Sequence Orthology more info
involved_in protein localization to lipid droplet	IEA Inferred from Electronic Annotation more info
involved_in protein localization to lipid droplet	ISO Inferred from Sequence Orthology more info
involved_in protein localization to lipid droplet	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to virus	IEA Inferred from Electronic Annotation more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info
involved_in retrograde protein transport, ER to cytosol	IEA Inferred from Electronic Annotation more info
involved_in retrograde protein transport, ER to cytosol	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in autophagosome	IEA Inferred from Electronic Annotation more info
located_in autophagosome	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: lipid droplet-regulating VLDL assembly factor AUP1

Names: ancient ubiquitous protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001079899.1 → NP_001073368.1 lipid droplet-regulating VLDL assembly factor AUP1

See identical proteins and their annotated locations for NP_001073368.1

Status: PROVISIONAL

Source sequence(s)

BC127544

UniProtKB/Swiss-Prot

A1L134

UniProtKB/TrEMBL

A0A8L2Q4W6

Related

ENSRNOP00000077286.2, ENSRNOT00000104950.2

Conserved Domains (2) summary

cd14420
Location:300 → 340

CUE_AUP1; CUE domain found in ancient ubiquitous protein 1 (AUP1) and similar proteins

cl17185
Location:66 → 264

LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

117118035..117121063

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063286675.1 → XP_063142745.1 lipid droplet-regulating VLDL assembly factor AUP1 isoform X1

Related

ENSRNOP00000010602.7, ENSRNOT00000010602.9
XM_008763029.3 → XP_008761251.1 lipid droplet-regulating VLDL assembly factor AUP1 isoform X2

UniProtKB/TrEMBL

A0A8I5YCA8

Conserved Domains (2) summary

cd14420
Location:300 → 340

CUE_AUP1; CUE domain found in ancient ubiquitous protein 1 (AUP1) and similar proteins

cl17185
Location:66 → 264

LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis