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    Pcgf1 polycomb group ring finger 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312480, updated on 2-Nov-2024

    Summary

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    Symbol
    Pcgf1provided by RGD
    Full Name
    polycomb group ring finger 1provided by RGD
    Primary source
    RGD:1549782
    See related
    EnsemblRapid:ENSRNOG00000051433 AllianceGenome:RGD:1549782
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nspc1
    Summary
    Predicted to enable promoter-specific chromatin binding activity. Predicted to be involved in chromatin remodeling and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of PRC1 complex. Orthologous to human PCGF1 (polycomb group ring finger 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 64.9), Thymus (RPKM 57.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pcgf1 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (117140144..117144729)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (115576165..115587019)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (113911129..113913718)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene DEAQ box RNA-dependent ATPase 1 Neighboring gene T-cell leukemia homeobox 2 Neighboring gene ladybird homeobox 2 Neighboring gene coiled-coil domain containing 142

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. NSPc1, a mainly nuclear localized protein of novel PcG family members, has a transcription repression activity related to its PKC phosphorylation site at S183. Gong Y, et al. FEBS Lett, 2005 Jan 3. PMID 15620699
    2. Age-related alterations in retinal neurovascular and inflammatory transcripts. Van Kirk CA, et al. Mol Vis, 2011. PMID 21633715, Free PMC Article
    3. BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase. Taherbhoy AM, et al. Nat Commun, 2015 Jul 7. PMID 26151332
    4. PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation. Almeida M, et al. Science, 2017 Jun 9. PMID 28596365, Free PMC Article
    5. PRC1 complex diversity: where is it taking us? Gil J, et al. Trends Cell Biol, 2014 Nov. PMID 25065329

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables promoter-specific chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of PRC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of PcG protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of PcG protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of PcG protein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    polycomb group RING finger protein 1
    Names
    nervous system Polycomb-1
    nervous system polycomb 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007000.2 → NP_001007001.2  polycomb group RING finger protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q6DLV9
      UniProtKB/TrEMBL
      A0A0G2JZ54, A6IAJ8
      Related
      ENSRNOP00000070914.2, ENSRNOT00000089635.3
      Conserved Domains (2) summary
      cd16733
      Location:44 → 86
      RING-HC_PCGF1; RING finger, HC subclass, found in polycomb group RING finger protein 1 (PCGF1) and similar proteins
      cd17081
      Location:166 → 253
      RAWUL_PCGF1; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 1 (PCGF1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      117140144..117144729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107592.2 → XP_038963520.1  polycomb group RING finger protein 1 isoform X1

      UniProtKB/TrEMBL
      G3V730
      Conserved Domains (1) summary
      cd17081
      Location:83 → 170
      RAWUL_PCGF1; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 1 (PCGF1) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DLV9.1 GenPept UniProtKB/Swiss-Prot:Q6DLV9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools