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    Ube2i ubiquitin-conjugating enzyme E2I [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25573, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ube2iprovided by RGD
    Official Full Name
    ubiquitin-conjugating enzyme E2Iprovided by RGD
    Primary source
    RGD:3926
    See related
    EnsemblRapid:ENSRNOG00000066579 AllianceGenome:RGD:3926
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ubc9; UbcE2A
    Summary
    Enables bHLH transcription factor binding activity; ionotropic glutamate receptor binding activity; and ubiquitin-like protein transferase activity. Involved in several processes, including positive regulation of DNA-binding transcription factor activity; protein sumoylation; and regulation of signal transduction. Located in dendrite and nucleus. Orthologous to human UBE2I (ubiquitin conjugating enzyme E2 I). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 383.0), Spleen (RPKM 264.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ube2i in Genome Data Viewer
    Location:
    10q12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (14782245..14802911, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14277749..14294681, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (14618615..14639274, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene TSR3 ribosome maturation factor Neighboring gene BAI1-associated protein 3 Neighboring gene microRNA 3547 Neighboring gene protease, serine, 34 Neighboring gene small nucleolar RNA SNORA70

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Developmental regulation of Ubc9 in the rat nervous system. Watanabe M, et al. Acta Biochim Pol, 2008. PMID 19039338
    2. Characterization of a new SUMO-1 nuclear body (SNB) enriched in pCREB, CBP, c-Jun in neuron-like UR61 cells. Navascués J, et al. Chromosoma, 2007 Oct. PMID 17549507
    3. Involvement of ubiquitination and sumoylation in bladder lesions induced by persistent long-term low dose ionizing radiation in humans. Romanenko AM, et al. J Urol, 2006 Feb. PMID 16407042
    4. Expression level of Ubc9 protein in rat tissues. Gołebiowski F, et al. Acta Biochim Pol, 2003. PMID 14739995
    5. UBE2I regulates the nuclear translocation of hnRNPA2B1 by contributing to SUMO modification in osteoarthritis. Xu H, et al. Gene, 2024 Nov 15. PMID 38955308

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UBE2I regulates the nuclear translocation of hnRNPA2B1 by contributing to SUMO modification in osteoarthritis.
      Title: UBE2I regulates the nuclear translocation of hnRNPA2B1 by contributing to SUMO modification in osteoarthritis.
    2. UBC9 regulates Nav1.5 expression levels in a SUMOylation-independent manner.
      Title: UBC9 regulates cardiac sodium channel Na(v)1.5 ubiquitination, degradation and sodium current density.
    3. ISH analysis revealed expression of Ubc9 was high in neuronal stem cells and moderate in differentiated neurons at embryonic stages but in adult brain, moderate expression was observed in dentate granular neurons and pyramidal neurons
      Title: Developmental regulation of Ubc9 in the rat nervous system.
    4. Immunohistochemistry showed that Ubc9 and PIAS1 are markedly expressed in rat adrenal glomerulosa cells
      Title: Ubc9 and Protein Inhibitor of Activated STAT 1 Activate Chicken Ovalbumin Upstream Promoter-Transcription Factor I-mediated Human CYP11B2 Gene Transcription.
    5. Glucocorticoid receptor ligand binding domain is sufficient for the modulation of glucocorticoid induction properties by homologous receptors, coactivator transcription intermediary factor 2, and Ubc9
      Title: Glucocorticoid receptor ligand binding domain is sufficient for the modulation of glucocorticoid induction properties by homologous receptors, coactivator transcription intermediary factor 2, and Ubc9.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105476

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables HLH domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RING-like zinc finger domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SUMO conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SUMO transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables SUMO transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables bHLH transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ionotropic glutamate receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small protein activating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear export ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of SUMO transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of intracellular steroid hormone receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein sumoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SUMO ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SUMO-conjugating enzyme UBC9
    Names
    RING-type E3 SUMO transferase UBC9
    SUMO-protein ligase
    Ubiquitin conjugating enzyme E2I (homologous to yeast UBC9)
    ubiquitin carrier protein 9
    ubiquitin carrier protein I
    ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)
    ubiquitin-conjugating enzyme UbcE2A
    ubiquitin-protein ligase I
    NP_037182.1
    XP_006245981.1
    XP_006245982.1
    XP_008765771.3
    XP_017452533.1
    XP_063124544.1
    XP_063124546.1
    XP_063124547.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001428972.1 → NP_001415901.1  SUMO-conjugating enzyme UBC9 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010

    2. NM_001428973.1 → NP_001415902.1  SUMO-conjugating enzyme UBC9 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P63281
      UniProtKB/TrEMBL
      A6HD16

    3. NM_001428974.1 → NP_001415903.1  SUMO-conjugating enzyme UBC9 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P63281
      UniProtKB/TrEMBL
      A6HD16

    4. NM_001428975.1 → NP_001415904.1  SUMO-conjugating enzyme UBC9 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P63281
      UniProtKB/TrEMBL
      A6HD16

    5. NM_001428976.1 → NP_001415905.1  SUMO-conjugating enzyme UBC9 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P63281
      UniProtKB/TrEMBL
      A6HD16

    6. NM_013050.3 → NP_037182.1  SUMO-conjugating enzyme UBC9 isoform 1

      See identical proteins and their annotated locations for NP_037182.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P63281
      UniProtKB/TrEMBL
      A6HD16
      Related
      ENSRNOP00000101344.1, ENSRNOT00000154507.1
      Conserved Domains (1) summary
      pfam00179
      Location:8 → 152
      UQ_con; Ubiquitin-conjugating enzyme

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      14782245..14802911 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268476.1 → XP_063124546.1  SUMO-conjugating enzyme UBC9 isoform X3

    2. XM_063268474.1 → XP_063124544.1  SUMO-conjugating enzyme UBC9 isoform X2

    3. XM_008767549.4 → XP_008765771.3  SUMO-conjugating enzyme UBC9 isoform X1

      UniProtKB/TrEMBL
      A0A0G2KB55
      Related
      ENSRNOP00000075659.2, ENSRNOT00000090085.3

    4. XM_006245920.5 → XP_006245982.1  SUMO-conjugating enzyme UBC9 isoform X4

      Conserved Domains (1) summary
      pfam00179
      Location:8 → 152
      UQ_con; Ubiquitin-conjugating enzyme

    5. XM_017597044.3 → XP_017452533.1  SUMO-conjugating enzyme UBC9 isoform X4

      Conserved Domains (1) summary
      pfam00179
      Location:8 → 152
      UQ_con; Ubiquitin-conjugating enzyme

    6. XM_063268477.1 → XP_063124547.1  SUMO-conjugating enzyme UBC9 isoform X5

    7. XM_006245919.5 → XP_006245981.1  SUMO-conjugating enzyme UBC9 isoform X4

      Conserved Domains (1) summary
      pfam00179
      Location:8 → 152
      UQ_con; Ubiquitin-conjugating enzyme
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63281.1 GenPept UniProtKB/Swiss-Prot:P63281

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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