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    Tspan4 tetraspanin 4 [ Mus musculus (house mouse) ]

    Gene ID: 64540, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tspan4provided by MGI
    Official Full Name
    tetraspanin 4provided by MGI
    Primary source
    MGI:MGI:1928097
    See related
    Ensembl:ENSMUSG00000025511 AllianceGenome:MGI:1928097
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NAG-2; Tm4sf7; Tspan-4; D130042I01Rik
    Summary
    Predicted to enable antigen binding activity and integrin binding activity. Acts upstream of or within mitocytosis and regulation of mitochondrial membrane potential. Located in migrasome. Is expressed in several structures, including gut; jaw; rib cage; urinary system; and viscerocranium. Orthologous to human TSPAN4 (tetraspanin 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in ovary adult (RPKM 100.6), adrenal adult (RPKM 68.1) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tspan4 in Genome Data Viewer
    Location:
    7 F5; 7 86.83 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141055194..141073340)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141475236..141493427)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10575 Neighboring gene STARR-positive B cell enhancer ABC_E11377 Neighboring gene CD151 antigen Neighboring gene polymerase (RNA) II (DNA directed) polypeptide L Neighboring gene chitinase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_20492 Neighboring gene STARR-seq mESC enhancer starr_20493 Neighboring gene adaptor-related protein complex 2, alpha 2 subunit Neighboring gene STARR-positive B cell enhancer ABC_E2855 Neighboring gene predicted gene, 16982 Neighboring gene microRNA 7063

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TSPAN4 and migrasomes in atherosclerosis regression correlated to myocardial infarction and pan-cancer progression. Zheng Y, et al. Cell Adh Migr, 2023 Dec. PMID 36513632, Free PMC Article
    2. Identification of a mouse orthologue of the CED-6 gene of Caenorhabditis elegans. Banerjee H, et al. Plasmid, 2003 Jan. PMID 12583998
    3. Identification and characterization of human PMP34, a protein closely related to the peroxisomal integral membrane protein PMP47 of Candida boidinii. Wylin T, et al. Eur J Biochem, 1998 Dec 1. PMID 9874197
    4. Mitocytosis, a migrasome-mediated mitochondrial quality-control process. Jiao H, et al. Cell, 2021 May 27. PMID 34048705
    5. NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins. Tachibana I, et al. J Biol Chem, 1997 Nov 14. PMID 9360996

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TSPAN4 and migrasomes in atherosclerosis regression correlated to myocardial infarction and pan-cancer progression.
      Title: TSPAN4 and migrasomes in atherosclerosis regression correlated to myocardial infarction and pan-cancer progression.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5)  1 citation
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102386

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables antigen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within mitocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of mitochondrial membrane potential IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in migrasome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tetraspanin-4
    Names
    novel antigen 2
    tetraspan TM4SF
    transmembrane 4 superfamily member 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252588.2 → NP_001239517.1  tetraspanin-4 isoform a

      See identical proteins and their annotated locations for NP_001239517.1

      Status: VALIDATED

      Source sequence(s)
      AC158224
      Consensus CDS
      CCDS22018.1
      UniProtKB/Swiss-Prot
      Q9DCK3
      UniProtKB/TrEMBL
      Q4FJW7
      Related
      ENSMUSP00000113085.2, ENSMUST00000117634.2
      Conserved Domains (2) summary
      cd03165
      Location:105 → 202
      NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:9 → 226
      Tetraspannin; Tetraspanin family

    2. NM_001403355.1 → NP_001390284.1  tetraspanin-4 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC158224
      UniProtKB/Swiss-Prot
      Q9DCK3
      UniProtKB/TrEMBL
      Q4FJW7

    3. NM_001403356.1 → NP_001390285.1  tetraspanin-4 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC158224
      UniProtKB/Swiss-Prot
      Q9DCK3
      UniProtKB/TrEMBL
      Q4FJW7

    4. NM_001403357.1 → NP_001390286.1  tetraspanin-4 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC158224
      UniProtKB/Swiss-Prot
      Q9DCK3
      UniProtKB/TrEMBL
      Q4FJW7

    5. NM_001403358.1 → NP_001390287.1  tetraspanin-4 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC158224
      UniProtKB/TrEMBL
      A0A668KLD1
      Related
      ENSMUSP00000159235.2, ENSMUST00000239217.2

    6. NM_053082.4 → NP_444312.1  tetraspanin-4 isoform a

      See identical proteins and their annotated locations for NP_444312.1

      Status: VALIDATED

      Source sequence(s)
      AC158224
      Consensus CDS
      CCDS22018.1
      UniProtKB/Swiss-Prot
      Q9DCK3
      UniProtKB/TrEMBL
      Q4FJW7
      Related
      ENSMUSP00000026585.8, ENSMUST00000026585.14
      Conserved Domains (2) summary
      cd03165
      Location:105 → 202
      NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:9 → 226
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      141055194..141073340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153326.1 → XP_036009219.1  tetraspanin-4 isoform X3

      Conserved Domains (1) summary
      cd03165
      Location:41 → 138
      NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...

    2. XM_036153327.1 → XP_036009220.1  tetraspanin-4 isoform X3

      Conserved Domains (1) summary
      cd03165
      Location:41 → 138
      NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCK3.1 GenPept UniProtKB/Swiss-Prot:Q9DCK3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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