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    Neurog2 neurogenin 2 [ Mus musculus (house mouse) ]

    Gene ID: 11924, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Neurog2provided by MGI
    Official Full Name
    neurogenin 2provided by MGI
    Primary source
    MGI:MGI:109619
    See related
    Ensembl:ENSMUSG00000027967 AllianceGenome:MGI:109619
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ngn2; Atoh4; ngn-2; Math4A; bHLHa8
    Summary
    Enables E-box binding activity. Involved in positive regulation of DNA-binding transcription factor activity. Acts upstream of or within several processes, including generation of neurons; positive regulation of neuron differentiation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo ectoderm; eye; and integumental system. Orthologous to human NEUROG2 (neurogenin 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E14 (RPKM 28.5), whole brain E14.5 (RPKM 22.8) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Neurog2 in Genome Data Viewer
    Location:
    3 G2; 3 56.54 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (127426382..127429285)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (127632733..127635636)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:127256185-127256372 Neighboring gene zinc finger, GRF-type containing 1 Neighboring gene STARR-seq mESC enhancer starr_08956 Neighboring gene predicted gene, 40147 Neighboring gene alpha-kinase 1 Neighboring gene STARR-seq mESC enhancer starr_08957 Neighboring gene VISTA enhancer mm1549 Neighboring gene ribosomal protein L19 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E335 Neighboring gene STARR-positive B cell enhancer ABC_E6120 Neighboring gene STARR-positive B cell enhancer ABC_E6121 Neighboring gene TRAF-interacting protein with forkhead-associated domain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Intraspinal transplantation of neurogenin-expressing stem cells generates spinal cord neural progenitors. Lunn JS, et al. Neurobiol Dis, 2012 Apr. PMID 22245661, Free PMC Article
    2. BMP and FGF-2 regulate neurogenin-2 expression and the differentiation of sensory neurons and glia. Ota M, et al. Dev Dyn, 2006 Mar. PMID 16425218
    3. Proliferating neuronal progenitors in the postnatal hippocampus transiently express the proneural gene Ngn2. Ozen I, et al. Eur J Neurosci, 2007 May. PMID 17466019
    4. Ectopic expression of neurogenin 2 alone is sufficient to induce differentiation of embryonic stem cells into mature neurons. Thoma EC, et al. PLoS One, 2012. PMID 22719915, Free PMC Article
    5. CEND1 and NEUROGENIN2 Reprogram Mouse Astrocytes and Embryonic Fibroblasts to Induced Neural Precursors and Differentiated Neurons. Aravantinou-Fatorou K, et al. Stem Cell Reports, 2015 Sep 8. PMID 26321141, Free PMC Article

    See all (539) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neuronal repair after spinal cord injury by in vivo astrocyte reprogramming mediated by the overexpression of NeuroD1 and Neurogenin-2.
      Title: Neuronal repair after spinal cord injury by in vivo astrocyte reprogramming mediated by the overexpression of NeuroD1 and Neurogenin-2.
    2. The Neurog2-Tbr2 axis forms a continuous transition to the neurogenic gene expression state in neural stem cells.
      Title: The Neurog2-Tbr2 axis forms a continuous transition to the neurogenic gene expression state in neural stem cells.
    3. Ascl1 and Ngn2 convert mouse embryonic stem cells to neurons via functionally distinct paths.
      Title: Ascl1 and Ngn2 convert mouse embryonic stem cells to neurons via functionally distinct paths.
    4. Neurog2 regulates Isl1 to modulate horizontal cell number.
      Title: Neurog2 regulates Isl1 to modulate horizontal cell number.
    5. Reprogramming astrocytes to motor neurons by activation of endogenous Ngn2 and Isl1.
      Title: Reprogramming astrocytes to motor neurons by activation of endogenous Ngn2 and Isl1.
    6. Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2.
      Title: Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2.
    7. A dynamic, spatially periodic, micro-pattern of HES5 underlies neurogenesis in the mouse spinal cord.
      Title: A dynamic, spatially periodic, micro-pattern of HES5 underlies neurogenesis in the mouse spinal cord.
    8. Neurog2 directly converts astrocytes into functional neurons in midbrain and spinal cord.
      Title: Neurog2 directly converts astrocytes into functional neurons in midbrain and spinal cord.
    9. Initiation of Otx2 expression in the developing mouse retina requires a unique enhancer and either Ascl1 or Neurog2 activity.
      Title: Initiation of Otx2 expression in the developing mouse retina requires a unique enhancer and either Ascl1 or Neurog2 activity.
    10. WNT signaling suppresses oligodendrogenesis via Ngn2-dependent direct inhibition of Olig2 expression.
      Title: WNT signaling suppresses oligodendrogenesis via Ngn2-dependent direct inhibition of Olig2 expression.
    Submit: New GeneRIF Correction See all GeneRIFs (73)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (12)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables E-box binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables E-box binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of Cajal-Retzius cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in axon development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell fate commitment IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cell maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within central nervous system neuron development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within central nervous system neuron development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within dopaminergic neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in forebrain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neurogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neurogenin-2
    Names
    atonal homolog 4
    helix-loop-helix protein mATH-4A
    protein atonal homolog 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009718.4 → NP_033848.1  neurogenin-2

      See identical proteins and their annotated locations for NP_033848.1

      Status: VALIDATED

      Source sequence(s)
      AC158308
      Consensus CDS
      CCDS17825.1
      UniProtKB/Swiss-Prot
      P70237, P70447
      UniProtKB/TrEMBL
      I3PQW5, Q6GTH9
      Related
      ENSMUSP00000029587.8, ENSMUST00000029587.9
      Conserved Domains (1) summary
      cd19717
      Location:104 → 172
      bHLH_TS_NGN2_ATOH4; basic helix-loop-helix (bHLH) domain found in neurogenin-2 (NGN-2) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      127426382..127429285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252394.1 → XP_030108254.1  neurogenin-2 isoform X1

      UniProtKB/Swiss-Prot
      P70237, P70447
      UniProtKB/TrEMBL
      I3PQW5, Q6GTH9
      Conserved Domains (1) summary
      cd19717
      Location:104 → 172
      bHLH_TS_NGN2_ATOH4; basic helix-loop-helix (bHLH) domain found in neurogenin-2 (NGN-2) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70447.1 GenPept UniProtKB/Swiss-Prot:P70447

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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