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    ZNF479 zinc finger protein 479 [ Homo sapiens (human) ]

    Gene ID: 90827, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZNF479provided by HGNC
    Official Full Name
    zinc finger protein 479provided by HGNC
    Primary source
    HGNC:HGNC:23258
    See related
    Ensembl:ENSG00000185177 MIM:617444; AllianceGenome:HGNC:23258
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KR19; HKr19
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis (RPKM 1.5) See more
    Orthologs
    all
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    Genomic context

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    See ZNF479 in Genome Data Viewer
    Location:
    7p11.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (57117676..57139864, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (57360976..57383153, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (57185383..57207571, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene septin 7 pseudogene 15 Neighboring gene gem-associated protein 7-like Neighboring gene GPCPD1 pseudogene 1 Neighboring gene vomeronasal 1 receptor 27 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Knockdown of ZNF479 inhibits proliferation and glycolysis of gastric cancer cells through regulating β-catenin/c-Myc signaling pathway. Jin XS, et al. Kaohsiung J Med Sci, 2021 Sep. PMID 34042257
    2. ZNF479 downregulates metallothionein-1 expression by regulating ASH2L and DNMT1 in hepatocellular carcinoma. Wu YJ, et al. Cell Death Dis, 2019 May 28. PMID 31138789, Free PMC Article
    3. Molecular cloning and preliminary functional analysis of two novel human KRAB zinc finger proteins, HKr18 and HKr19. Mark C, et al. DNA Cell Biol, 2001 May. PMID 11410164
    4. Interactome of the negative regulator of nuclear import BRCA1-binding protein 2. Fatima S, et al. Sci Rep, 2015 Mar 30. PMID 25820252, Free PMC Article
    5. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown of ZNF479 inhibits proliferation and glycolysis of gastric cancer cells through regulating beta-catenin/c-Myc signaling pathway.
      Title: Knockdown of ZNF479 inhibits proliferation and glycolysis of gastric cancer cells through regulating β-catenin/c-Myc signaling pathway.
    2. ZNF479 regulates metallothionein-1 expression by modulating ASH2L in hepatocellular carcinoma.
      Title: ZNF479 downregulates metallothionein-1 expression by regulating ASH2L and DNMT1 in hepatocellular carcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 479
    Names
    KRAB zinc finger protein KR19
    zinc finger protein Kr19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370129.2 → NP_001357058.1  zinc finger protein 479

      Status: VALIDATED

      Source sequence(s)
      AC099654, AC122133, AC125231
      Consensus CDS
      CCDS43590.1
      UniProtKB/Swiss-Prot
      Q96JC4
      Related
      ENSP00000324518.6, ENST00000319636.10
      Conserved Domains (4) summary
      smart00349
      Location:16 → 76
      KRAB; krueppel associated box
      COG5048
      Location:170 → 372
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:243 → 263
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:480 → 503
      zf-H2C2_2; Zinc-finger double domain

    2. NM_033273.3 → NP_150376.1  zinc finger protein 479

      See identical proteins and their annotated locations for NP_150376.1

      Status: VALIDATED

      Source sequence(s)
      AC099654, AC122133, AC125231
      Consensus CDS
      CCDS43590.1
      UniProtKB/Swiss-Prot
      Q96JC4
      Related
      ENSP00000333776.4, ENST00000331162.8
      Conserved Domains (4) summary
      smart00349
      Location:16 → 76
      KRAB; krueppel associated box
      COG5048
      Location:170 → 372
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:243 → 263
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:480 → 503
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      57117676..57139864 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011515604.4 → XP_011513906.2  zinc finger protein 479 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      57360976..57383153 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359305.1 → XP_054215280.1  zinc finger protein 479 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96JC4.1 GenPept UniProtKB/Swiss-Prot:Q96JC4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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