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    Tfip11 tuftelin interacting protein 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288718, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Tfip11provided by RGD
    Official Full Name
    tuftelin interacting protein 11provided by RGD
    Primary source
    RGD:1311449
    See related
    EnsemblRapid:ENSRNOG00000000663 AllianceGenome:RGD:1311449
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable nucleic acid binding activity. Predicted to be involved in negative regulation of protein binding activity; negative regulation of protein-containing complex assembly; and spliceosomal complex disassembly. Predicted to be located in chromosome, telomeric region; extracellular matrix; and nuclear lumen. Predicted to be part of U2-type post-mRNA release spliceosomal complex and catalytic step 2 spliceosome. Orthologous to human TFIP11 (tuftelin interacting protein 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 65.5), Thymus (RPKM 64.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tfip11 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (49960025..49972257, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (44299619..44311851, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (50320820..50333052, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene aspartate beta-hydroxylase domain containing 2 Neighboring gene coiled-coil domain-containing protein 121-like Neighboring gene HPS4, biogenesis of lysosomal organelles complex 3 subunit 2 Neighboring gene SRR1 domain containing Neighboring gene tyrosylprotein sulfotransferase 2 Neighboring gene crystallin, beta B1 Neighboring gene crystallin, beta A4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel nuclear localization signal and speckle-targeting sequence of tuftelin-interacting protein 11, a splicing factor involved in spliceosome disassembly. Tannukit S, et al. Biochem Biophys Res Commun, 2009 Dec 18. PMID 19857462, Free PMC Article
    2. Isolation and characterization of post-splicing lariat-intron complexes. Yoshimoto R, et al. Nucleic Acids Res, 2009 Feb. PMID 19103666, Free PMC Article
    3. A tuftelin-interacting protein (TIP39) localizes to the apical secretory pole of mouse ameloblasts. Paine CT, et al. J Biol Chem, 2000 Jul 21. PMID 10806191
    4. Conserved interactions of the splicing factor Ntr1/Spp382 with proteins involved in DNA double-strand break repair and telomere metabolism. Herrmann G, et al. Nucleic Acids Res, 2007. PMID 17389648, Free PMC Article
    5. Characterization of STIP, a multi-domain nuclear protein, highly conserved in metazoans, and essential for embryogenesis in Caenorhabditis elegans. Ji Q, et al. Exp Cell Res, 2007 Apr 15. PMID 17289020

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biomineral tissue development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spliceosomal complex disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spliceosomal complex disassembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spliceosomal complex disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spliceosomal complex disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of U2-type post-mRNA release spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type post-mRNA release spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type post-mRNA release spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tuftelin-interacting protein 11
    Names
    STIP-1
    septin and tuftelin-interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008291.1 → NP_001008292.1  tuftelin-interacting protein 11

      See identical proteins and their annotated locations for NP_001008292.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085809
      UniProtKB/Swiss-Prot
      Q5U2Y6
      UniProtKB/TrEMBL
      A0A8I6A3N9, A6J264
      Related
      ENSRNOP00000000828.3, ENSRNOT00000000828.6
      Conserved Domains (3) summary
      pfam01585
      Location:149 → 193
      G-patch; G-patch domain
      pfam07842
      Location:397 → 666
      GCFC; GC-rich sequence DNA-binding factor-like protein
      pfam12457
      Location:18 → 104
      TIP_N; Tuftelin interacting protein N terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      49960025..49972257 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271216.1 → XP_063127286.1  tuftelin-interacting protein 11 isoform X1

      UniProtKB/Swiss-Prot
      Q5U2Y6
      UniProtKB/TrEMBL
      A0A8I6A3N9, A6J264
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U2Y6.1 GenPept UniProtKB/Swiss-Prot:Q5U2Y6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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