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    GAS5 growth arrest specific 5 [ Homo sapiens (human) ]

    Gene ID: 60674, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GAS5provided by HGNC
    Official Full Name
    growth arrest specific 5provided by HGNC
    Primary source
    HGNC:HGNC:16355
    See related
    Ensembl:ENSG00000234741 MIM:608280; AllianceGenome:HGNC:16355
    Gene type
    ncRNA
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SNHG2; NCRNA00030
    Summary
    This gene produces a spliced long non-coding RNA and is a member of the 5' terminal oligo-pyrimidine class of genes. It is a small nucleolar RNA host gene, containing multiple C/D box snoRNA genes in its introns. Part of the secondary RNA structure of the encoded transcript mimics glucocorticoid response element (GRE) which means it can bind to the DNA binding domain of the glucocorticoid receptor (nuclear receptor subfamily 3, group C, member 1). This action blocks the glucocorticoid receptor from being activated and thereby stops it from regulating the transcription of its target genes. This transcript is also thought to regulate the transcriptional activity of other receptors, such as androgen, progesterone and mineralocorticoid receptors, that can bind to its GRE mimic region. Multiple functions have been associated with this transcript, including cellular growth arrest and apoptosis. It has also been identified as a potential tumor suppressor, with its down-regulation associated with cancer in multiple different tissues. [provided by RefSeq, Mar 2015]
    Expression
    Ubiquitous expression in ovary (RPKM 307.5), thyroid (RPKM 113.4) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GAS5 in Genome Data Viewer
    Location:
    1q25.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (173863901..173869045, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (173222019..173227165, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (173833039..173838183, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 160 Neighboring gene MPRA-validated peak463 silencer Neighboring gene centromere protein L Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2116 Neighboring gene H3K27ac hESC enhancers GRCh37_chr1:173793515-173794033 and GRCh37_chr1:173794034-173794551 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:173795193-173795706 Neighboring gene aspartyl-tRNA synthetase 2, mitochondrial Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:173821280-173822182 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:173830052-173830768 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:173830769-173831485 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1556 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:173837597-173838796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2118 Neighboring gene GAS5 antisense RNA 1 Neighboring gene small nucleolar RNA, C/D box 81 Neighboring gene small nucleolar RNA, C/D box 47 Neighboring gene small nucleolar RNA, H/ACA box 103 Neighboring gene small nucleolar RNA, C/D box 80 Neighboring gene small nucleolar RNA, C/D box 79 Neighboring gene small nucleolar RNA, C/D box 78 Neighboring gene small nucleolar RNA, C/D box 44 Neighboring gene small nucleolar RNA, C/D box 77 Neighboring gene small nucleolar RNA, C/D box 76 Neighboring gene small nucleolar RNA, C/D box 75 Neighboring gene small nucleolar RNA, C/D box 74 Neighboring gene zinc finger and BTB domain containing 37 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:173863193-173864392 Neighboring gene serpin family C member 1 Neighboring gene uncharacterized LOC124904457 Neighboring gene RNA, 5S ribosomal pseudogene 67

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Downregulated Long Noncoding RNA GAS5 Fails to Function as Decoy of CEBPB, Resulting in Increased GDF15 Expression and Rapid Ovarian Cancer Cell Proliferation. Guo LL, et al. Cancer Biother Radiopharm, 2019 Oct. PMID 31314588
    2. Overexpression of Growth-Arrest-Specific Transcript 5 Improved Cisplatin Sensitivity in Hepatocellular Carcinoma Through Sponging miR-222. Zhao P, et al. DNA Cell Biol, 2020 Apr. PMID 32213078
    3. Long non-coding RNA GAS5 regulates the growth and metastasis of human cervical cancer cells via induction of apoptosis and cell cycle arrest. Yan Z, et al. Arch Biochem Biophys, 2020 May 15. PMID 32105659
    4. Molecular and Cellular Mechanisms of Action of Tumour Suppressor GAS5 LncRNA. Pickard MR, et al. Genes (Basel), 2015 Jul 7. PMID 26198250, Free PMC Article
    5. lncRNA GAS5-promoted apoptosis in triple-negative breast cancer by targeting miR-378a-5p/SUFU signaling. Zheng S, et al. J Cell Biochem, 2020 Mar. PMID 31692053

    See all (269) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Association of long noncoding RNA GAS5 gene polymorphism with progression of diabetic kidney disease.
      Title: Association of long noncoding RNA GAS5 gene polymorphism with progression of diabetic kidney disease.
    2. Serum Levels of Long Non-coding RNAs NEAT1, GAS5, and GAPLINC Altered in Rheumatoid Arthritis.
      Title: Serum Levels of Long Non-coding RNAs NEAT1, GAS5, and GAPLINC Altered in Rheumatoid Arthritis.
    3. Expression profiles of the lncRNA antisense GAS5-AS1 in colon biopsies from pediatric inflammatory bowel disease patients and its role in regulating sense transcript GAS5.
      Title: Expression profiles of the lncRNA antisense GAS5-AS1 in colon biopsies from pediatric inflammatory bowel disease patients and its role in regulating sense transcript GAS5.
    4. The lncRNAs Gas5, MALAT1 and SNHG8 as diagnostic biomarkers for epithelial malignant pleural mesothelioma in Egyptian patients.
      Title: The lncRNAs Gas5, MALAT1 and SNHG8 as diagnostic biomarkers for epithelial malignant pleural mesothelioma in Egyptian patients.
    5. Intron Editing Reveals SNORD-Dependent Maturation of the Small Nucleolar RNA Host Gene GAS5 in Human Cells.
      Title: Intron Editing Reveals SNORD-Dependent Maturation of the Small Nucleolar RNA Host Gene GAS5 in Human Cells.
    6. Exploring GAS5's impact on prostate cancer: Recent discoveries and emerging paradigms.
      Title: Exploring GAS5's impact on prostate cancer: Recent discoveries and emerging paradigms.
    7. Reduction of GAS5 and FOXD3-AS1 long non-coding RNAs in patients with bipolar disorder.
      Title: Reduction of GAS5 and FOXD3-AS1 long non-coding RNAs in patients with bipolar disorder.
    8. GAS5 silencing attenuates hypoxia-induced cardiomyocytes injury by targeting miR-21/PTEN.
      Title: GAS5 silencing attenuates hypoxia-induced cardiomyocytes injury by targeting miR-21/PTEN.
    9. Long Noncoding Rna GAS5 And Mir-137 And Two Of Their Genetic Polymorphisms Contribute To Acute Ischaemic Stroke Risk In An Egyptian Population.
      Title: Long Noncoding Rna GAS5 And Mir-137 And Two Of Their Genetic Polymorphisms Contribute To Acute Ischaemic Stroke Risk In An Egyptian Population.
    10. LncRNA GAS5 as an Inflammatory Regulator Acting through Pathway in Human Lupus.
      Title: LncRNA GAS5 as an Inflammatory Regulator Acting through Pathway in Human Lupus.
    Submit: New GeneRIF Correction See all GeneRIFs (254)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: CENPL

    Homology

    Other Names

    • growth arrest specific 5 (non-protein coding)
    • growth arrest specific transcript 5
    • small nucleolar RNA host gene (non-protein coding) 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_002578.4 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000687189.2

    2. NR_152521.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000430245.5

    3. NR_152522.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000686995.2

    4. NR_152523.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000689238.2

    5. NR_152524.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000689958.2

    6. NR_152525.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000827949.1

    7. NR_152526.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000693348.2

    8. NR_152527.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000687435.2

    9. NR_152528.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000687549.1

    10. NR_152529.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000449289.8

    11. NR_152530.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000827948.1

    12. NR_152531.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170

    13. NR_152532.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000691213.2

    14. NR_152533.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000450589.7

    15. NR_152534.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000687022.2

    16. NR_186255.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000452197.6

    17. NR_186256.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000827993.1

    18. NR_186257.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000827970.1

    19. NR_186258.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170

    20. NR_186259.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000827972.1

    21. NR_186260.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170

    22. NR_186261.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000691982.2

    23. NR_186262.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000827958.1

    24. NR_186263.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000828016.1

    25. NR_186264.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000688952.2

    26. NR_186265.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000703059.1

    27. NR_186266.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000827989.1

    28. NR_186267.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000827992.1

    29. NR_186268.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000690761.2

    30. NR_186269.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000828009.1

    31. NR_186270.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000827986.1

    32. NR_186271.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170

    33. NR_186272.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000827979.1

    34. NR_186273.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170

    35. NR_186274.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170

    36. NR_186275.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000690228.2

    37. NR_186277.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000828007.1

    38. NR_186278.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000828020.1

    39. NR_186279.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170

    40. NR_186280.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000827956.1

    41. NR_186281.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000690448.2

    42. NR_186282.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000691137.2

    43. NR_186283.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000690172.2

    44. NR_186284.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000448718.7

    45. NR_186285.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000827981.1

    46. NR_186286.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000687987.2

    47. NR_186287.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170

    48. NR_186288.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170

    49. NR_186289.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170

    50. NR_186290.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      173863901..173869045 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      173222019..173227165 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials