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    NUBP1 NUBP iron-sulfur cluster assembly factor 1, cytosolic [ Homo sapiens (human) ]

    Gene ID: 4682, updated on 2-Nov-2024

    Summary

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    Official Symbol
    NUBP1provided by HGNC
    Official Full Name
    NUBP iron-sulfur cluster assembly factor 1, cytosolicprovided by HGNC
    Primary source
    HGNC:HGNC:8041
    See related
    Ensembl:ENSG00000103274 MIM:600280; AllianceGenome:HGNC:8041
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NBP; NBP1; CIAO5; NBP35
    Summary
    NUBP1 is a member of the NUBP/MRP subfamily of ATP-binding proteins (Nakashima et al., 1999 [PubMed 10486206]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in adrenal (RPKM 9.0), heart (RPKM 8.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NUBP1 in Genome Data Viewer
    Location:
    16p13.13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (10743842..10769351)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (10779762..10805269)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (10837699..10863208)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene MT-ATP6 pseudogene 24 Neighboring gene MT-CO3 pseudogene 24 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10385 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10386 Neighboring gene trans-golgi network vesicle protein 23 homolog A Neighboring gene NANOG hESC enhancer GRCh37_chr16:10883659-10884197 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10387 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10388 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10389 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7194 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:10932437-10932956 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10391 Neighboring gene Rho GTPase activating protein 21 pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:10964767-10965966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10393 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10395 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10396 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10397 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10398 Neighboring gene class II major histocompatibility complex transactivator Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10399 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10400 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10401 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7195 Neighboring gene Dexi homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Unraveling the mechanism of [4Fe-4S] cluster assembly on the N-terminal cluster binding site of NUBP1. Bargagna B, et al. Protein Sci, 2023 May. PMID 36916754, Free PMC Article
    2. Cloning of a human cDNA encoding a putative nucleotide-binding protein related to Escherichia coli MinD. Shahrestanifar M, et al. Gene, 1994 Sep 30. PMID 7926816
    3. GLRX3 Acts as a [2Fe-2S] Cluster Chaperone in the Cytosolic Iron-Sulfur Assembly Machinery Transferring [2Fe-2S] Clusters to NUBP1. Camponeschi F, et al. J Am Chem Soc, 2020 Jun 17. PMID 32429669, Free PMC Article
    4. Human Nbp35 is essential for both cytosolic iron-sulfur protein assembly and iron homeostasis. Stehling O, et al. Mol Cell Biol, 2008 Sep. PMID 18573874, Free PMC Article
    5. The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm. Taniguchi N, et al. J Biol Chem, 2000 Oct 13. PMID 10915798

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Unraveling the mechanism of [4Fe-4S] cluster assembly on the N-terminal cluster binding site of NUBP1.
      Title: Unraveling the mechanism of [4Fe-4S] cluster assembly on the N-terminal cluster binding site of NUBP1.
    2. GLRX3 Acts as a [2Fe-2S] Cluster Chaperone in the Cytosolic Iron-Sulfur Assembly Machinery Transferring [2Fe-2S] Clusters to NUBP1.
      Title: GLRX3 Acts as a [2Fe-2S] Cluster Chaperone in the Cytosolic Iron-Sulfur Assembly Machinery Transferring [2Fe-2S] Clusters to NUBP1.
    3. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: PTEN identified as important risk factor of chronic obstructive pulmonary disease.
    5. The cytosolic soluble P-loop NTPase termed huNbp35 (also known as Nubp1) was identified as an Fe/S protein, and its role in the maturation of Fe/S proteins in HeLa cells, is defined.
      Title: Human Nbp35 is essential for both cytosolic iron-sulfur protein assembly and iron homeostasis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117406, MGC130052, MGC130053

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent FeS chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables iron-sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centrosome localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron-sulfur cluster assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of centrosome duplication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    cytosolic Fe-S cluster assembly factor NUBP1
    Names
    NBP 1
    nucleotide binding protein (e.coli MinD like)
    nucleotide binding protein 1 (E.coli MinD like)
    nucleotide binding protein 1 (MinD homolog, E. coli)
    nucleotide-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278506.2 → NP_001265435.1  cytosolic Fe-S cluster assembly factor NUBP1 isoform 2

      See identical proteins and their annotated locations for NP_001265435.1

      Status: VALIDATED

      Source sequence(s)
      AK223204, BC100290, BP225034
      Consensus CDS
      CCDS61839.1
      UniProtKB/Swiss-Prot
      P53384
      Related
      ENSP00000409654.2, ENST00000433392.6
      Conserved Domains (1) summary
      pfam10609
      Location:53 → 292
      ParA; NUBPL iron-transfer P-loop NTPase

    2. NM_001323594.2 → NP_001310523.1  cytosolic Fe-S cluster assembly factor NUBP1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC074136

    3. NM_001323595.2 → NP_001310524.1  cytosolic Fe-S cluster assembly factor NUBP1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC074136
      Conserved Domains (2) summary
      COG0489
      Location:38 → 273
      Mrp; Chromosome partitioning ATPase, Mrp family, contains Fe-S cluster [Cell cycle control, cell division, chromosome partitioning]
      pfam10609
      Location:53 → 273
      ParA; NUBPL iron-transfer P-loop NTPase

    4. NM_001323596.2 → NP_001310525.1  cytosolic Fe-S cluster assembly factor NUBP1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC074136

    5. NM_001323597.1 → NP_001310526.1  cytosolic Fe-S cluster assembly factor NUBP1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC074136

    6. NM_002484.4 → NP_002475.2  cytosolic Fe-S cluster assembly factor NUBP1 isoform 1

      See identical proteins and their annotated locations for NP_002475.2

      Status: VALIDATED

      Source sequence(s)
      AK223204, BP225034
      Consensus CDS
      CCDS10543.1
      UniProtKB/Swiss-Prot
      P53384, Q32M30, Q498A9, Q53FS7
      Related
      ENSP00000283027.5, ENST00000283027.10
      Conserved Domains (2) summary
      TIGR01969
      Location:57 → 303
      minD_arch; cell division ATPase MinD, archaeal
      pfam10609
      Location:53 → 303
      ParA; NUBPL iron-transfer P-loop NTPase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      10743842..10769351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434170.1 → XP_047290126.1  cytosolic Fe-S cluster assembly factor NUBP1 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      10779762..10805269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380401.1 → XP_054236376.1  cytosolic Fe-S cluster assembly factor NUBP1 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53384.2 GenPept UniProtKB/Swiss-Prot:P53384

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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