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    [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852434, updated on 11-Sep-2024

    Summary

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    Primary source
    SGD:S000000341
    Locus tag
    YBR137W
    See related
    AllianceGenome:SGD:S000000341; FungiDB:YBR137W; VEuPathDB:YBR137W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in posttranslational protein targeting to endoplasmic reticulum membrane. Located in cytoplasm. Part of TRC complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (513044..513583)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene cyclin-dependent protein kinase regulatory subunit CKS1 Neighboring gene protein kinase MEC1 Neighboring gene uncharacterized protein Neighboring gene carboxypeptidase C

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and functional characterization of ybr137wp implicates its involvement in the targeting of tail-anchored proteins to membranes. Yeh YH, et al. Mol Cell Biol, 2014 Dec. PMID 25288638, Free PMC Article
    2. Disruption of six novel yeast genes located on chromosome II reveals one gene essential for vegetative growth and two required for sporulation and conferring hypersensitivity to various chemicals. Kucharczyk R, et al. Yeast, 1999 Jul. PMID 10407278
    3. Cooperative and independent activities of Sgt2 and Get5 in the targeting of tail-anchored proteins. Kohl C, et al. Biol Chem, 2011 Jul. PMID 21619481
    4. The karyopherin Kap142p/Msn5p mediates nuclear import and nuclear export of different cargo proteins. Yoshida K, et al. J Cell Biol, 2001 Feb 19. PMID 11266464, Free PMC Article
    5. A chaperone cascade sorts proteins for posttranslational membrane insertion into the endoplasmic reticulum. Wang F, et al. Mol Cell, 2010 Oct 8. PMID 20850366, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in post-translational protein targeting to endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in post-translational protein targeting to endoplasmic reticulum membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TRC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TRC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_009695.2
    • Protein with a role in ER delivery of tail-anchored membrane proteins; interacts with Sgt2p; binds to the TRC complex, which inserts proteins into the ER membrane; interacts with Msn5p karyopherin; YBR137W is not an essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      513044..513583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178485.2 → NP_009695.2  TPA: uncharacterized protein YBR137W [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009695.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQD3, P38276
      UniProtKB/TrEMBL
      A6ZL80, B3LN20, C7GY19, D3UEN1, G2W9E0, N1P9H4
      Conserved Domains (1) summary
      COG4702
      Location:9 → 179
      COG4702; Uncharacterized protein, UPF0303 family [Function unknown]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38276.4

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