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    COS111 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852502, updated on 11-Sep-2024

    Summary

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    Official Symbol
    COS111
    Primary source
    SGD:S000000407
    Locus tag
    YBR203W
    See related
    AllianceGenome:SGD:S000000407; FungiDB:YBR203W; VEuPathDB:YBR203W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in signal transduction. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (629168..631942)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Min7p Neighboring gene mini-chromosome maintenance complex protein 7 Neighboring gene triacylglycerol lipase Neighboring gene mannosyltransferase KTR3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The possible mechanism of action of ciclopirox olamine in the yeast Saccharomyces cerevisiae. Leem SH, et al. Mol Cells, 2003 Feb 28. PMID 12661761
    2. Functional analysis of 12 ORFs from Saccharomyces cerevisiae chromosome II. Rodríguez-Navarro S, et al. Yeast, 1999 Jul. PMID 10407271
    3. Identification of F-box proteins that are involved in resistance to methylmercury in Saccharomyces cerevisiae. Hwang GW, et al. FEBS Lett, 2006 Dec 22. PMID 17141224
    4. Recurrent background mutations in WHI2 impair proteostasis and degradation of misfolded cytosolic proteins in Saccharomyces cerevisiae. Comyn SA, et al. Sci Rep, 2017 Jun 23. PMID 28646136, Free PMC Article
    5. Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis. Patton EE, et al. Trends Genet, 1998 Jun. PMID 9635407

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    Cos111p
    NP_009762.2
    • Protein required for antifungal drug ciclopirox olamine resistance; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      629168..631942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178551.2 → NP_009762.2  TPA: Cos111p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009762.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQK1, P38308
      UniProtKB/TrEMBL
      G2W9K8, N1P6Z5
      Conserved Domains (1) summary
      pfam12937
      Location:187 → 231
      F-box-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38308.2

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