ECM5 Ecm5p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: ECM5
Official Full Name: Ecm5p
Primary source: SGD:S000004788
Locus tag: YMR176W
See related: AllianceGenome:SGD:S000004788; FungiDB:YMR176W; VEuPathDB:YMR176W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable histone H3-tri/di/monomethyl-lysine-4 demethylase activity. Involved in cellular response to oxidative stress. Located in cytoplasm and nucleus. Part of Snt2C complex. Human ortholog(s) of this gene implicated in ankylosing spondylitis; autosomal recessive non-syndromic intellectual disability; breast cancer; high grade glioma; and syndromic X-linked intellectual disability Claes-Jensen type. Orthologous to several human genes including KDM5A (lysine demethylase 5A); KDM5B (lysine demethylase 5B); and KDM5C (lysine demethylase 5C). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Data indicate that Snt2, Ecm5, and Rpd3 physically associate.
Title: The yeast Snt2 protein coordinates the transcriptional response to hydrogen peroxide-mediated oxidative stress.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
NOT enables histone demethylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in cell wall organization	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Snt2C complex	HDA more info	PubMed
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_013901.1

Subunit of the Snt2C complex; physically associates with Snt2p and Rpd3p; along with Snt2p, recruits Rpd3p to a small number of promoters; also colocalizes with Snt2p, independently of Rpd3p, to promoters of stress response genes in response to oxidative stress; contains ATP/GTP-binding site motif A; null mutant exhibits increased cellular volume, large drooping buds with elongated necks; relative distribution to the nucleus increases upon DNA replication stress

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The following sections contain reference sequences that belong to a specific genome build. Explain