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    Nexn nexilin (F actin binding protein) [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246172, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Nexnprovided by RGD
    Official Full Name
    nexilin (F actin binding protein)provided by RGD
    Primary source
    RGD:708354
    See related
    EnsemblRapid:ENSRNOG00000012512 AllianceGenome:RGD:708354
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables actin filament binding activity. Predicted to be involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; neuron development; and regulation of cytoskeleton organization. Predicted to act upstream of or within response to bacterium. Located in Z disc and focal adhesion. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1CC and hypertrophic cardiomyopathy 20. Orthologous to human NEXN (nexilin F-actin binding protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 446.3), Heart (RPKM 437.4) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nexn in Genome Data Viewer
    Location:
    2q45
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (243846736..243878268, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (241186783..241218315, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (257452937..257484607, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member B4 Neighboring gene far upstream element binding protein 1 Neighboring gene transmembrane protein 256, pseudogene 2 Neighboring gene mitoguardin 1 Neighboring gene uncharacterized LOC120100974 Neighboring gene ubiquitin specific peptidase 33

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Nexilin, a cardiomyopathy-associated F-actin binding protein, binds and regulates IRS1 signaling in skeletal muscle cells. Lee A, et al. PLoS One, 2013. PMID 23383252, Free PMC Article
    2. NELIN, a new F-actin associated protein, stimulates HeLa cell migration and adhesion. Wang W, et al. Biochem Biophys Res Commun, 2005 May 20. PMID 15823560
    3. Hepatocyte growth factor upregulates nexilin gene expression in cardiomyocytes via JNK pathway. Wang C, et al. Genet Mol Res, 2014 Jul 4. PMID 25062485
    4. Nexilin: a novel actin filament-binding protein localized at cell-matrix adherens junction. Ohtsuka T, et al. J Cell Biol, 1998 Nov 30. PMID 9832551, Free PMC Article
    5. Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy. Hassel D, et al. Nat Med, 2009 Nov. PMID 19881492

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hepatocyte growth factor upregulates nexilin gene expression in cardiomyocytes via JNK pathway.
      Title: Hepatocyte growth factor upregulates nexilin gene expression in cardiomyocytes via JNK pathway.
    2. Nexilin, a cardiomyopathy-associated F-actin binding protein, binds and regulates IRS1 signaling in skeletal muscle cells.
      Title: Nexilin, a cardiomyopathy-associated F-actin binding protein, binds and regulates IRS1 signaling in skeletal muscle cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cell-cell adhesion mediator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of muscle IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of muscle ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of muscle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dendrite self-avoidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell-substrate junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nexilin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139230.2 → NP_631976.1  nexilin isoform b

      See identical proteins and their annotated locations for NP_631976.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (b) encodes the longer isoform (b).
      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q9Z2J3, Q9Z2J4
      UniProtKB/TrEMBL
      A6HWK8
      Related
      ENSRNOP00000073825.2, ENSRNOT00000083344.3
      Conserved Domains (2) summary
      cd00096
      Location:579 → 646
      Ig; Immunoglobulin domain
      pfam07679
      Location:562 → 651
      I-set; Immunoglobulin I-set domain

    2. NM_139231.2 → NP_631977.1  nexilin isoform s

      See identical proteins and their annotated locations for NP_631977.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (s) has multiple differences in the coding region but maintains the reading frame, compared to variant s. This variant encodes isoform s, which is shorter than isoform b.
      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6HWK7
      Related
      ENSRNOP00000058811.4, ENSRNOT00000066780.4
      Conserved Domains (2) summary
      pfam07679
      Location:512 → 601
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:512 → 514
      Ig; Ig strand A [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      243846736..243878268 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233479.5 → XP_006233541.1  nexilin isoform X1

      See identical proteins and their annotated locations for XP_006233541.1

      UniProtKB/TrEMBL
      A0A8I5ZUL4, A0A8L2QTU4, A6HWK9
      Related
      ENSRNOP00000082246.1, ENSRNOT00000111795.2
      Conserved Domains (3) summary
      PTZ00121
      Location:25 → 549
      PTZ00121; MAEBL; Provisional
      pfam07679
      Location:576 → 665
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:576 → 578
      Ig; Ig strand A [structural motif]

    2. XM_006233485.4 → XP_006233547.1  nexilin isoform X3

      UniProtKB/TrEMBL
      A6HWK7
      Conserved Domains (2) summary
      cd00096
      Location:515 → 582
      Ig; Immunoglobulin domain
      pfam07679
      Location:498 → 587
      I-set; Immunoglobulin I-set domain

    3. XM_039101727.2 → XP_038957655.1  nexilin isoform X2

      UniProtKB/TrEMBL
      A6HWK7
      Conserved Domains (2) summary
      pfam07679
      Location:512 → 601
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:512 → 514
      Ig; Ig strand A [structural motif]

    4. XM_063281296.1 → XP_063137366.1  nexilin isoform X3

      UniProtKB/TrEMBL
      A6HWK7

    5. XM_006233480.5 → XP_006233542.1  nexilin isoform X1

      See identical proteins and their annotated locations for XP_006233542.1

      UniProtKB/TrEMBL
      A0A8I5ZUL4, A0A8L2QTU4, A6HWK9
      Conserved Domains (3) summary
      PTZ00121
      Location:25 → 549
      PTZ00121; MAEBL; Provisional
      pfam07679
      Location:576 → 665
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:576 → 578
      Ig; Ig strand A [structural motif]

    6. XM_039101726.2 → XP_038957654.1  nexilin isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZUL4, A0A8L2QTU4, A6HWK9
      Conserved Domains (3) summary
      PTZ00121
      Location:25 → 549
      PTZ00121; MAEBL; Provisional
      pfam07679
      Location:576 → 665
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:576 → 578
      Ig; Ig strand A [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z2J4.1 GenPept UniProtKB/Swiss-Prot:Q9Z2J4

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