U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ENO1 phosphopyruvate hydratase ENO1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853169, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ENO1
    Official Full Name
    phosphopyruvate hydratase ENO1
    Primary source
    SGD:S000003486
    Locus tag
    YGR254W
    See related
    AllianceGenome:SGD:S000003486; FungiDB:YGR254W; VEuPathDB:YGR254W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HSP48
    Summary
    Enables melatonin binding activity and phosphopyruvate hydratase activity. Involved in glycolytic process and regulation of vacuole fusion, non-autophagic. Located in fungal-type vacuole and mitochondrion. Part of phosphopyruvate hydratase complex. Human ortholog(s) of this gene implicated in Alzheimer's disease and prostate cancer. Orthologous to several human genes including ENO1 (enolase 1) and ENO3 (enolase 3). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ENO1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (1000927..1002240)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene histone acetyltransferase GCN5 Neighboring gene proteasome core particle subunit alpha 5 Neighboring gene putative N,N-dimethylaniline monooxygenase COQ6 Neighboring gene tRNA-Thr

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification of a sequence containing the positive regulatory region of Saccharomyces cerevisiae gene ENO1. Uemura H, et al. Gene, 1986. PMID 3536667
    2. Influence of cytosolic conditions on the reaction equilibrium and the reaction enthalpy of the enolase reaction accessed by calorimetry and van 't HOFF. Vogel K, et al. Biochim Biophys Acta Gen Subj, 2020 Oct. PMID 32610157
    3. Effect of site-directed mutagenesis of His373 of yeast enolase on some of its physical and enzymatic properties. Brewer JM, et al. Biochim Biophys Acta, 1997 Jun 20. PMID 9217018
    4. A positive regulatory sequence of the Saccharomyces cerevisiae ENO1 gene. Uemura H, et al. J Biochem, 1987 Jul. PMID 3117780
    5. Mechanism of enolase: the crystal structure of asymmetric dimer enolase-2-phospho-D-glycerate/enolase-phosphoenolpyruvate at 2.0 A resolution. Zhang E, et al. Biochemistry, 1997 Oct 14. PMID 9376357

    See all (179) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Influence of cytosolic conditions on the reaction equilibrium and the reaction enthalpy of the enolase reaction accessed by calorimetry and van 't HOFF.
      Title: Influence of cytosolic conditions on the reaction equilibrium and the reaction enthalpy of the enolase reaction accessed by calorimetry and van 't HOFF.
    2. Systems biology approach reveals possible evolutionarily conserved moonlighting functions for enolase
      Title: Systems biology approach reveals possible evolutionarily conserved moonlighting functions for enolase.
    3. The mechanism may be important for yeast cells under hypoxia, to quickly provide both energy and substrates for the biosynthesis of lipids and proteins independently of the tricarboxylic acid (TCA) cycle and also to fit changing environments.
      Title: Spatial reorganization of Saccharomyces cerevisiae enolase to alter carbon metabolism under hypoxia.
    4. A comparison between in vivo glycated enolase and purified enolase glycated in vitro revealed marked differences.
      Title: Protein glycation in vivo: functional and structural effects on yeast enolase.
    5. These results suggest that Ree1p functions in the galactose metabolic pathway via the Gal83 protein and that it may control the level of Eno1p, which is also affected by the Snf1 complex, in S. cerevisiae.
      Title: Novel Ree1 regulates the expression of ENO1 via the Snf1 complex pathway in Saccharomyces cerevisiae.
    6. Effects of the G376E and G157D mutations on the stability of yeast enolase
      Title: Effects of the G376E and G157D mutations on the stability of yeast enolase--a model for human muscle enolase deficiency.
    7. enolase stimulates vacuole fusion and enolase and Bor1p regulate selective protein trafficking to the vacuole
      Title: Enolase activates homotypic vacuole fusion and protein transport to the vacuole in yeast.
    8. Expression of an ENO1-lacZ reporter was also regulated by the other eight bHLH proteins, namely, Ino2p, Ino4p, Cbf1p, Rtg1p, Rtg3p, Pho4p, Hms1p, and Ygr290wp.
      Title: Multiple basic helix-loop-helix proteins regulate expression of the ENO1 gene of Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables melatonin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphopyruvate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphopyruvate hydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphopyruvate hydratase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of vacuole fusion, non-autophagic IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of vacuole fusion, non-autophagic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of phosphopyruvate hydratase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phosphopyruvate hydratase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of phosphopyruvate hydratase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    phosphopyruvate hydratase ENO1
    NP_011770.3
    • Enolase I, a phosphopyruvate hydratase; catalyzes conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression repressed in response to glucose; protein abundance increases in response to DNA replication stress; N-terminally propionylated in vivo; ENO1 has a paralog, ENO2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      1000927..1002240
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181383.3 → NP_011770.3  TPA: phosphopyruvate hydratase ENO1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011770.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV34, P00924
      UniProtKB/TrEMBL
      B3LHY6, B5VJJ6, N1P439
      Conserved Domains (1) summary
      PTZ00081
      Location:1 → 430
      PTZ00081; enolase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00924.3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous