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    MES1 methionine--tRNA ligase MES1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853181, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MES1
    Official Full Name
    methionine--tRNA ligase MES1
    Primary source
    SGD:S000003496
    Locus tag
    YGR264C
    See related
    AllianceGenome:SGD:S000003496; FungiDB:YGR264C; VEuPathDB:YGR264C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables methionine-tRNA ligase activity and sequence-specific mRNA binding activity. Involved in methionyl-tRNA aminoacylation. Located in cytoplasmic stress granule. Part of methionyl glutamyl tRNA synthetase complex. Used to study Charcot-Marie-Tooth disease axonal type 2U and pulmonary alveolar proteinosis. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2U; hereditary spastic paraplegia 70; and trichothiodystrophy. Orthologous to human MARS1 (methionyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See MES1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (1019598..1021853, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase BUD32 Neighboring gene steryl deacetylase Neighboring gene uncharacterized protein Neighboring gene GTP cyclohydrolase I

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Binding of the yeast tRNA(Met) anticodon by the cognate methionyl-tRNA synthetase involves at least two independent peptide regions. Despons L, et al. J Mol Biol, 1992 Jun 5. PMID 1602489
    2. The presence of a D-stem but not a T-stem is essential for triggering aminoacylation upon anticodon binding in yeast methionine tRNA. Senger B, et al. J Mol Biol, 1995 May 26. PMID 7776375
    3. Strategy for the mass spectrometric verification and correction of the primary structures of proteins deduced from their DNA sequences. Gibson BW, et al. Proc Natl Acad Sci U S A, 1984 Apr. PMID 6371805, Free PMC Article
    4. Primary structure of the Saccharomyces cerevisiae gene for methionyl-tRNA synthetase. Walter P, et al. Proc Natl Acad Sci U S A, 1983 May. PMID 6341994, Free PMC Article
    5. A mutant of yeast with a defective methionyl-tRNA synthetase. McLaughlin CS, et al. Genetics, 1969 Mar. PMID 5377463, Free PMC Article

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methionine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methionine-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methionine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in methionyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in methionyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in methionyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of methionyl glutamyl tRNA synthetase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    methionine--tRNA ligase MES1
    NP_011780.3
    • Methionyl-tRNA synthetase; forms a complex with Gus1p, a glutamyl-tRNA synthetase, and Arc1p, which increases the catalytic efficiency of both synthetases; involved in the nuclear export of tRNAs; mutations in human ortholog MARS is associated with pediatric pulmonary alveolar proteinosis, interstitial lung and liver disease, and Charcot-Marie-Tooth disease; human MARS gene can complement the yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      1019598..1021853 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181393.3 → NP_011780.3  TPA: methionine--tRNA ligase MES1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011780.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV43, P00958
      UniProtKB/TrEMBL
      A6ZUS2, B3LHX8, C8Z9F6, N1P448
      Conserved Domains (2) summary
      PLN02610
      Location:190 → 750
      PLN02610; probable methionyl-tRNA synthetase
      pfam09635
      Location:11 → 132
      MetRS-N; MetRS-N binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00958.4

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