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    POLR2H RNA polymerase II, I and III subunit H [ Homo sapiens (human) ]

    Gene ID: 5437, updated on 28-Oct-2024

    Summary

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    Official Symbol
    POLR2Hprovided by HGNC
    Official Full Name
    RNA polymerase II, I and III subunit Hprovided by HGNC
    Primary source
    HGNC:HGNC:9195
    See related
    Ensembl:ENSG00000163882 MIM:606023; AllianceGenome:HGNC:9195
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RPB8; RPB17; RPABC3
    Summary
    The three eukaryotic RNA polymerases are complex multisubunit enzymes that play a central role in the transcription of nuclear genes. This gene encodes an essential and highly conserved subunit of RNA polymerase II that is shared by the other two eukaryotic DNA-directed RNA polymerases, I and III. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
    Expression
    Ubiquitous expression in duodenum (RPKM 14.6), small intestine (RPKM 13.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See POLR2H in Genome Data Viewer
    Location:
    3q27.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (184361710..184368591)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (187170978..187177848)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (184079498..184086379)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr3:184053938-184054138 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:184055930-184056541 Neighboring gene family with sequence similarity 131 member A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20909 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:184061884-184062636 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:184062637-184063388 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:184063389-184064141 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:184064142-184064893 Neighboring gene chloride voltage-gated channel 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:184077025-184077538 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:184077539-184078050 Neighboring gene uncharacterized LOC124906311 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14964 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14965 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14966 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20910 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20911 Neighboring gene thrombopoietin Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:184103787-184104288 Neighboring gene chordin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Characterization of RNA polymerase type II from human term placenta. Freund E, et al. J Cell Physiol, 1986 Jun. PMID 3754875
    2. Small extrachromosomal circular DNAs, microDNA, produce short regulatory RNAs that suppress gene expression independent of canonical promoters. Paulsen T, et al. Nucleic Acids Res, 2019 May 21. PMID 30828735, Free PMC Article
    3. Structural, biochemical, and dynamic characterizations of the hRPB8 subunit of human RNA polymerases. Kang X, et al. J Biol Chem, 2006 Jun 30. PMID 16632472
    4. Intrinsic disorder drives N-terminal ubiquitination by Ube2w. Vittal V, et al. Nat Chem Biol, 2015 Jan. PMID 25436519, Free PMC Article
    5. BRCA1 ubiquitinates RPB8 in response to DNA damage. Wu W, et al. Cancer Res, 2007 Feb 1. PMID 17283126

    See all (215) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We also show that endogenous microDNA associate with RNA polymerases subunits, POLR2H and POLR3F. Together, these results suggest that microDNA may modulate gene expression through the production of both known and novel regulatory small RNA.
      Title: Small extrachromosomal circular DNAs, microDNA, produce short regulatory RNAs that suppress gene expression independent of canonical promoters.
    2. Observational study of gene-disease association, gene-gene interaction, and genetic testing. (HuGE Navigator)
      Title: A panel of sputum-based genomic marker for early detection of lung cancer.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: New genetic associations detected in a host response study to hepatitis B vaccine.
    4. Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
      Title: Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.
    5. hRPB8 interacts with single-stranded DNA nonspecifically and adopts significant conformational changes, and the hRPB8/single-stranded DNA complex is a fast exchanging system
      Title: Structural, biochemical, and dynamic characterizations of the hRPB8 subunit of human RNA polymerases.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of polymerase (RNA) II (DNA directed) polypeptide H (POLR2H) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120 PubMed
    Tat tat The interaction of Tip110 with HIV-1 Tat leads to a higher efficiency of elongation for RNAPII complexes formed on the LTR promoter PubMed
    tat Expression of both Tip110 and Tat enhances phosphorylation of RNAPII at both serine 2 and serine 5, which account for Tip110 function in transcription activation PubMed
    tat The interaction of Tip110 with HIV-1 Tat and the RNAPII C-terminal domain leads to the recruitment of increased CDK9/CycT1 to the transcription complex PubMed
    tat HIV-1 Tat complexes with RNA polymerase II and cellular transcription factors as part of the HIV-1 transcription preinitiation and elongation complexes and stimulates RNA polymerase II processivity by inducing the phosphorylation of its C-terminal Domain PubMed
    tat A small molecule compound C3 inhibits HIV-1 replication by suppressing HIV-1 Tat-mediated HIV-1 LTR-driven gene expression and phosphorylation of RNAPII through inhibition of Tat binding to CycT1 PubMed
    tat JQ1, a small molecule inhibitor of Brd4, directly dissociates Brd4 from HIV-1 promoter and promotes subsequently HIV-1 Tat binding to HIV-1 promoter, resulting in increased phosphorylation of RNA polymerase II and viral transcription PubMed
    tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed
    Vpr vpr HIV-1 Vpr interacts with basal transcription complexes such as P-TEFb, TFIIH, TFIID (TBP) and TFIIB which activate RNA polymerase II gene transcription PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to RNA polymerase I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase II activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transcription by RNA polymerase I IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase III IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase I complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA polymerase II, core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase II, core complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-DNA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-directed RNA polymerases I, II, and III subunit RPABC3
    Names
    DNA-directed RNA polymerase II subunit H
    DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide
    RNA polymerase II subunit H
    RPB8 homolog
    polymerase (RNA) II (DNA directed) polypeptide H
    polymerase (RNA) II subunit H
    NP_001265627.1
    NP_001265628.1
    NP_001265629.1
    NP_001265643.1
    NP_001265644.1
    NP_001333808.1
    NP_001376505.1
    NP_001376507.1
    NP_001376508.1
    NP_001376510.1
    NP_001376511.1
    NP_001376512.1
    NP_001376513.1
    NP_001376514.1
    NP_001376515.1
    NP_001376516.1
    NP_001376517.1
    NP_006223.2
    XP_006713729.1
    XP_006713730.1
    XP_016862125.1
    XP_047304297.1
    XP_047304298.1
    XP_047304299.1
    XP_054202886.1
    XP_054202887.1
    XP_054202888.1
    XP_054202889.1
    XP_054202890.1
    XP_054202891.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278698.2 → NP_001265627.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 1

      See identical proteins and their annotated locations for NP_001265627.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AA431357, BG529732, BX283032, CN368789, Z49199
      Consensus CDS
      CCDS63859.1
      UniProtKB/Swiss-Prot
      P52434
      Related
      ENSP00000415536.1, ENST00000429568.1
      Conserved Domains (1) summary
      smart00658
      Location:2 → 106
      RPOL8c; RNA polymerase subunit 8

    2. NM_001278699.3 → NP_001265628.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 3

      See identical proteins and their annotated locations for NP_001265628.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, uses a downstream start codon and uses an alternate splice site in the 3' coding region, resulting in a frameshift, compared to variant 1. Variants 3 and 4 encode the same isoform (3), which is shorter and has a distinct C-terminus, compared to isoform 1. Variants 3, 4, and 15-18 all encode the same isoform (3).
      Source sequence(s)
      AC078797
      Consensus CDS
      CCDS63861.1
      UniProtKB/Swiss-Prot
      P52434
      Conserved Domains (1) summary
      smart00658
      Location:1 → 111
      RPOL8c; RNA polymerase subunit 8

    3. NM_001278700.2 → NP_001265629.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 3

      See identical proteins and their annotated locations for NP_001265629.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an alternate 5' terminal exon, initiates translation at a downstream start codon and uses an alternate splice site in the 3' coding region, resulting in a frameshift, compared to variant 1. Variants 3 and 4 encode the same isoform (3), which is shorter and has a distinct C-terminus, compared to isoform 1. Variants 3, 4, and 15-18 all encode the same isoform (3).
      Source sequence(s)
      AA431357, AC078797, BM541682, BX283032, HY178178, Z49199
      Consensus CDS
      CCDS63861.1
      UniProtKB/Swiss-Prot
      P52434
      Related
      ENSP00000398622.1, ENST00000438240.5
      Conserved Domains (1) summary
      smart00658
      Location:1 → 111
      RPOL8c; RNA polymerase subunit 8

    4. NM_001278714.2 → NP_001265643.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 4

      See identical proteins and their annotated locations for NP_001265643.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 5' coding region and uses an alternate splice site in the 3' coding region, resulting in a frameshift, compared to variant 1. It encodes isoform 4, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AI244238, BQ065952, BX283032, CN368789
      Consensus CDS
      CCDS63860.1
      UniProtKB/TrEMBL
      C9JLU1
      Related
      ENSP00000411883.1, ENST00000430783.5
      Conserved Domains (1) summary
      smart00658
      Location:2 → 119
      RPOL8c; RNA polymerase subunit 8

    5. NM_001278715.2 → NP_001265644.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 5

      See identical proteins and their annotated locations for NP_001265644.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and has multiple coding region differences compared to variant 1, one of which results in a frameshift. It encodes isoform 5 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AA431357, BI603667, BQ065952, BX283032, CN368789, Z49199
      Consensus CDS
      CCDS63862.1
      UniProtKB/Swiss-Prot
      P52434
      Related
      ENSP00000393773.1, ENST00000443489.5
      Conserved Domains (1) summary
      cl02716
      Location:1 → 83
      RNA_pol_Rpb8; RNA polymerase Rpb8

    6. NM_001346879.2 → NP_001333808.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC078797
      Conserved Domains (1) summary
      cl02716
      Location:1 → 70
      RNA_pol_Rpb8; RNA polymerase Rpb8

    7. NM_001389576.1 → NP_001376505.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC078797
      Consensus CDS
      CCDS3264.1
      UniProtKB/Swiss-Prot
      C9J413, C9JBJ6, C9JCU7, C9JUA8, P52434, P53802, Q969R0
      UniProtKB/TrEMBL
      C9JLU1
      Conserved Domains (1) summary
      smart00658
      Location:2 → 147
      RPOL8c; RNA polymerase subunit 8

    8. NM_001389578.1 → NP_001376507.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC078797
      Consensus CDS
      CCDS3264.1
      UniProtKB/Swiss-Prot
      C9J413, C9JBJ6, C9JCU7, C9JUA8, P52434, P53802, Q969R0
      UniProtKB/TrEMBL
      C9JLU1
      Conserved Domains (1) summary
      smart00658
      Location:2 → 147
      RPOL8c; RNA polymerase subunit 8

    9. NM_001389579.1 → NP_001376508.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC078797
      Consensus CDS
      CCDS3264.1
      UniProtKB/Swiss-Prot
      C9J413, C9JBJ6, C9JCU7, C9JUA8, P52434, P53802, Q969R0
      UniProtKB/TrEMBL
      C9JLU1
      Conserved Domains (1) summary
      smart00658
      Location:2 → 147
      RPOL8c; RNA polymerase subunit 8

    10. NM_001389581.1 → NP_001376510.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC078797
      Consensus CDS
      CCDS3264.1
      UniProtKB/Swiss-Prot
      C9J413, C9JBJ6, C9JCU7, C9JUA8, P52434, P53802, Q969R0
      UniProtKB/TrEMBL
      C9JLU1
      Conserved Domains (1) summary
      smart00658
      Location:2 → 147
      RPOL8c; RNA polymerase subunit 8

    11. NM_001389582.1 → NP_001376511.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC078797
      Consensus CDS
      CCDS3264.1
      UniProtKB/Swiss-Prot
      C9J413, C9JBJ6, C9JCU7, C9JUA8, P52434, P53802, Q969R0
      UniProtKB/TrEMBL
      C9JLU1
      Conserved Domains (1) summary
      smart00658
      Location:2 → 147
      RPOL8c; RNA polymerase subunit 8

    12. NM_001389583.1 → NP_001376512.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC078797
      Consensus CDS
      CCDS3264.1
      UniProtKB/Swiss-Prot
      C9J413, C9JBJ6, C9JCU7, C9JUA8, P52434, P53802, Q969R0
      UniProtKB/TrEMBL
      C9JLU1
      Conserved Domains (1) summary
      smart00658
      Location:2 → 147
      RPOL8c; RNA polymerase subunit 8

    13. NM_001389584.1 → NP_001376513.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC078797
      Consensus CDS
      CCDS3264.1
      UniProtKB/Swiss-Prot
      C9J413, C9JBJ6, C9JCU7, C9JUA8, P52434, P53802, Q969R0
      UniProtKB/TrEMBL
      C9JLU1
      Related
      ENSP00000409065.1, ENST00000455712.5
      Conserved Domains (1) summary
      smart00658
      Location:2 → 147
      RPOL8c; RNA polymerase subunit 8

    14. NM_001389585.1 → NP_001376514.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC078797
      Consensus CDS
      CCDS63861.1
      Conserved Domains (1) summary
      smart00658
      Location:1 → 111
      RPOL8c; RNA polymerase subunit 8

    15. NM_001389586.1 → NP_001376515.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC078797
      Consensus CDS
      CCDS63861.1
      Conserved Domains (1) summary
      smart00658
      Location:1 → 111
      RPOL8c; RNA polymerase subunit 8

    16. NM_001389587.1 → NP_001376516.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC078797
      Consensus CDS
      CCDS63861.1
      Conserved Domains (1) summary
      smart00658
      Location:1 → 111
      RPOL8c; RNA polymerase subunit 8

    17. NM_001389588.1 → NP_001376517.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC078797
      Consensus CDS
      CCDS63861.1
      Related
      ENSP00000399882.1, ENST00000452961.5
      Conserved Domains (1) summary
      smart00658
      Location:1 → 111
      RPOL8c; RNA polymerase subunit 8

    18. NM_006232.5 → NP_006223.2  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 2

      See identical proteins and their annotated locations for NP_006223.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1. Variants 2 and 8-14 all encode the same isoform (2).
      Source sequence(s)
      AC078797
      Consensus CDS
      CCDS3264.1
      UniProtKB/Swiss-Prot
      C9J413, C9JBJ6, C9JCU7, C9JUA8, P52434, P53802, Q969R0
      UniProtKB/TrEMBL
      C9JLU1
      Related
      ENSP00000392913.1, ENST00000456318.6
      Conserved Domains (1) summary
      smart00658
      Location:2 → 147
      RPOL8c; RNA polymerase subunit 8

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      184361710..184368591
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006713666.4 → XP_006713729.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1

      See identical proteins and their annotated locations for XP_006713729.1

      UniProtKB/Swiss-Prot
      P52434
      Conserved Domains (1) summary
      smart00658
      Location:2 → 106
      RPOL8c; RNA polymerase subunit 8

    2. XM_017006636.3 → XP_016862125.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X2

      UniProtKB/TrEMBL
      C9JLU1
      Conserved Domains (1) summary
      smart00658
      Location:2 → 119
      RPOL8c; RNA polymerase subunit 8

    3. XM_006713667.3 → XP_006713730.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1

      See identical proteins and their annotated locations for XP_006713730.1

      UniProtKB/Swiss-Prot
      P52434
      Conserved Domains (1) summary
      smart00658
      Location:2 → 106
      RPOL8c; RNA polymerase subunit 8

    4. XM_047448341.1 → XP_047304297.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1

    5. XM_047448342.1 → XP_047304298.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1

    6. XM_047448343.1 → XP_047304299.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      187170978..187177848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346911.1 → XP_054202886.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1

    2. XM_054346916.1 → XP_054202891.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X2

    3. XM_054346913.1 → XP_054202888.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1

    4. XM_054346912.1 → XP_054202887.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1

    5. XM_054346914.1 → XP_054202889.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1

    6. XM_054346915.1 → XP_054202890.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52434.4 GenPept UniProtKB/Swiss-Prot:P52434

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